DLX5 antibody - N-terminal region (ARP31607_P050)
- Known as:
- DLX5 (anti-) - N-terminal region (ARP31607_P050)
- Catalog number:
- arp31607_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- DLX5 antibody - N-terminal region (ARP31607_P050)
Related genes to: DLX5 antibody - N-terminal region (ARP31607_P050)
- Gene:
- DLX5 NIH gene
- Name:
- distal-less homeobox 5
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-24
- Date modifiied:
- 2019-04-23
Related products to: DLX5 antibody - N-terminal region (ARP31607_P050)
Related articles to: DLX5 antibody - N-terminal region (ARP31607_P050)
- Mammalian palates are composed of the anterior hard palate and the posterior soft palate. However, the correlation of the genesis, pattern formation, and morphogenesis between the hard and soft palates remains elusive. - Source: PubMed
Publication date: 2026/03/20
Wang BiyingXue JunyuanBian YufanDeng JiaminLiu BoLi NanZhu LeiXiao JingLiu ChaoLiu Han - () has long been used to treat nasal congestion, allergic rhinitis, and sinusitis. In the current study, we demonstrate the effects and underlying mechanisms of flower water extract (ME) and ME-derived constituent magnolin on in vitro osteoblastogenic and anti-osteoclastogenic responses. Treatment with ME or magnolin markedly enhanced the osteoblast differentiation and mineralization in MC3T3-E1 pre-osteoblasts. This osteoblastogenic activity of ME or magnolin was closely associated with upregulation of osteoblast-specific molecules, including RUNX2, DLX5, OSX, alkaline phosphatase, collagen type I, and osteopontin, as well as the activation of mitogen-activated protein kinase (MAPK) signaling pathways. Concurrently, magnolin inhibited osteoclast differentiation through inactivating MAPK pathways and downregulating NFATc1, c-Fos, tartrate-resistant acid phosphatase, and cathepsin K in RANKL-treated RAW264.7 cells. These observations suggest that ME and magnolin have pharmacological potential for the treatment and prevention of metabolic bone disorders, including osteoporosis. - Source: PubMed
Publication date: 2026/03/07
Lee Do HunPark Ju-HyoungSeo Dong-Wan - Understanding the causes of the exceptional rate of evolution of the mammalian placenta is likely to aid the understanding of placental development and the etiology of the human-specific pregnancy disorder pre-eclampsia (PE). As retroelements are often lineage-specific and known to be co-opted for placental function, here we consider the binding of the transcription factors GATA3 and DLX5 to retroelements. These factors are dysregulated in pre-eclampsia, as are their downstream consequences. - Source: PubMed
Publication date: 2026/03/09
Singh ManvendraQu YuliangPande AmitZadora JuliannaHerse FlorianGauster MartinKong XuhuiZheng RongyanAnwar RabiaStevanovic KatarinaDechend RalfCohen MarieMolvarec AttilaWang JichangKonkel Miriam KZhang BinFeschotte CedricDveksler GabrielaBlois Sandra MHurst Laurence DIzsvák Zsuzsanna - Biological targeted therapies show promise for personalized treatment of head and neck squamous cell carcinoma (HNSCC), but the intrinsic heterogeneity of hypopharyngeal squamous cell carcinoma (HPSCC) presents significant treatment challenges. - Source: PubMed
Publication date: 2026/03/03
Jiang YaoLi LianheWang HongminWang MingqiongZou Liangyu - The bone marrow endosteum provides a robust source of bone-making osteoblasts by housing various types of osteoblast precursor cells, including endosteal stem cells expressing fibroblast growth factor receptor 3 (Fgfr3) and their downstream progenitor cell populations. In fetal bone development, Dlx5 marks early perichondrial cells that populate the diaphyseal bone and marrow stroma in the postnatal stages. However, the location of Dlx5-expressing cells in the postnatal bone marrow and how they contribute to osteogenesis remain undefined. Here, we show that Dlx5 cells are preferentially localized to the endosteal space in the postnatal bone marrow and provide a robust yet transient source of trabecular bone-making osteoblasts. Cell-lineage analyses by Dlx5-creER reveal that these Dlx5 endosteal precursor cells robustly contribute to osteoblasts and reticular stromal cells, whereas cell type-specific Hedgehog activation by Ptch1-deletion prematurely shifted their cell fates toward marrow adipocytes, leading to cortical and trabecular bone thinning with spontaneous fractures. Therefore, our findings identify postnatal Dlx5 cells as Hedgehog-susceptible osteoblast precursors, unraveling a new mechanism governing osteogenic fates of bone marrow endosteal precursor cells. - Source: PubMed
Publication date: 2026/02/27
Kondo KeitaMatsushita YukiOrikasa ShionNakai YutaKuroda AikoOhba ShinsukeOno WanidaOno Noriaki