ZBTB8 antibody - C-terminal region (ARP31552_P050)
- Known as:
- ZBTB8 (anti-) - C-terminal region (ARP31552_P050)
- Catalog number:
- arp31552_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZBTB8 antibody - C-terminal region (ARP31552_P050)
Related genes to: ZBTB8 antibody - C-terminal region (ARP31552_P050)
- Gene:
- ZBTB8A NIH gene
- Name:
- zinc finger and BTB domain containing 8A
- Previous symbol:
- ZBTB8
- Synonyms:
- BOZF1, FLJ90065, ZNF916A
- Chromosome:
- 1p35.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-16
- Date modifiied:
- 2016-10-05
Related products to: ZBTB8 antibody - C-terminal region (ARP31552_P050)
Related articles to: ZBTB8 antibody - C-terminal region (ARP31552_P050)
- The study investigated subtropical Egyptian goat populations (382 does) from different hot dry ecological zones (Upper Egypt, Coastal Zone of Western Desert, and New Valley Desert Oasis) to identify genes associated with tolerance to heat stress. Animals were encouraged to walk for 7 km under direct solar radiation from 12:00 to 14:00 pm in July and August (imitating summer grazing on poor pasture under hot dry conditions). Temperature Humidity Index (THI) ranged from 98.6 to 109.3, indicating that the animals were under severe heat stress. Physiological parameters were measured at rest (7:00 am) and after exposure to heat stress (14.00 pm). Animal heat tolerant index (AHTI) was estimated from their response in the four main physiological parameters ranged from (0: high tolerant to 4: low tolerant). The GWAS analysis revealed 90 marker SNPs associated with heat stress in 108 genotypes of Egyptian goat. Ninety markers are found in forty-seven distinct genes distributed across the genome. In terms of the markers (SNPs) that have direct effect on these traits via homozygous alleles, twenty-eight SNPs are connected to heat stress. The snpeff approach revealed that KDM6A, TRPM3, USP54, GLTSCR2, NAALADL2, GATAD2A, CTNNA2, LOC102175876, ZBTB8A, ETNPPL, LRRC43, SNTB1, RPS6KA5, and ARHGAP26 genes influence tolerance to heat stress. These genes offer crucial insights into the biological mechanisms that enhance resilience to elevated temperature conditions. The studied subtropical Egyptian goat breeds showed a high ability to tolerate heat stress and identifying these genomic loci can be utilized to monitor and control tolerance of subtropical goat to heat stress, while maintaining their production performance. - Source: PubMed
Publication date: 2025/06/11
Aboul-Naga Adel MAlsamman Alsamman MMelak SherifNassar Ahmed EAbdelsabour Taha HGamal LayalyAdley MonicaElshafie Mohmed H - This study investigates the genetic underpinnings of wool traits, specifically fibre diameter (FD) and staple length (SL), in Middle Anatolian Merino sheep using multi-locus genome-wide association study (GWAS) approaches. Representing the first attempt to examine these polygenic traits with multi-locus methods, the analysis employed four techniques: mrMLM, FASTmrMLM, FASTmrEMMA, and ISIS EM-BLASSO. A total of 18 Quantitative Trait Nucleotides (QTNs) were identified for FD, with 7 co-detected by multiple methods, and 14 QTNs were identified for SL, with 5 co-detected by multiple methods. Post-hoc power analysis revealed high statistical power for both traits (FD: 0.95, SL: 0.91). Notably, three candidate genes-PTPN3, TCF4, and ZBTB8A-were found to be consistent with prior studies. Gene enrichment and pathway analyses reaffirmed the complex and multifactorial molecular mechanisms governing wool traits. These findings enhance our understanding of the polygenic nature of wool traits, shedding light on the intricate genetic regulation and pinpointing genomic regions potentially influencing wool physiology. By identifying specific QTNs associated with FD and SL, this research provides a foundation for elucidating the genetic mechanisms underlying these economically significant traits. Upon validation in diverse populations, these findings hold substantial promise for the application of marker-assisted selection (MAS) to improve wool traits. - Source: PubMed
Publication date: 2025/03/27
Yaman YalçınÖnaldi A TanerDoğan ŞükrüKirbaş MesutBehrem SedatKal Yavuz - The formation of dynamic protein filaments contributes to various biological functions by clustering individual molecules together and enhancing their binding to ligands. We report such a propensity for the BTB domains of certain proteins from the ZBTB family, a large eukaryotic transcription factor family implicated in differentiation and cancer. Working with Xenopus laevis and human proteins, we solved the crystal structures of filaments formed by dimers of the BTB domains of ZBTB8A and ZBTB18 and demonstrated concentration-dependent higher-order assemblies of these dimers in solution. In cells, the BTB-domain filamentation supports clustering of full-length human ZBTB8A and ZBTB18 into dynamic nuclear foci and contributes to the ZBTB18-mediated repression of a reporter gene. The BTB domains of up to 21 human ZBTB family members and two related proteins, NACC1 and NACC2, are predicted to behave in a similar manner. Our results suggest that filamentation is a more common feature of transcription factors than is currently appreciated. - Source: PubMed
Mance LucijaBigot NicolasZhamungui Sánchez EdisonCoste FranckMartín-González NataliaZentout SihamBiliškov MarinPukało ZofiaMishra AanchalChapuis CatherineArteni Ana-AndreeaLateur AxelleGoffinont StéphaneGaudon VirginieTalhaoui IbtissamCasuso IgnacioBeaufour MartineGarnier NorbertArtzner FranckCadene MartineHuet SébastienCastaing BertrandSuskiewicz Marcin Józef - To investigate the expression of ZBTB8A (zinc finger and BTB domain containing 8A) in gastric cancer tissues and its clinical significance. - Source: PubMed
Wu Jin-huiFeng Yu-jieSun Zhi-jianHu Ji-linGao YuanZhang Xian-xiangZhang Mao-shenZhang Bing-yuanLu Yun - The human POZ domain and Krüppel-like zinc finger (POK) family proteins play important roles in the regulation of apoptosis, cell proliferation, differentiation, development, oncogenesis, and tumor suppression. A novel POK family transcription factor, BTB/POZ and zinc finger domains factor on chromosome 1 (BOZF-1; also called ZBTB8A), contains a POZ domain and two C2H2-type Krüppel-like zinc fingers and is localized at nuclear speckles. Compared with paired normal tissues, BOZF1 expression is increased in cancer tissues of the prostate, breast, and cervix. BOZF1 repressed the transcription of p21WAF/CDKN1A by acting on the proximal promoter concentrated with Sp1-binding GC boxes. BOZF1 competed with Sp1 in binding to GC boxes 1-5/6 of the CDKN1A proximal promoter. In addition, BOZF1 interacted with p53 and decreased the acetylation of p53 by p300, which reduced the DNA binding activity of p53 at the far distal p53-binding element. BOZF1 blocked the two major molecular events that are important in both constitutive and inducible transcription activation of CDKN1A. BOZF1 is unique in that it bound to all the proximal GC boxes to repress transcription, and it inhibited p53 acetylation without affecting p53 stability. BOZF1 might be a novel proto-oncoprotein that stimulates cell proliferation. - Source: PubMed
Publication date: 2013/01/17
Kim Min-KyeongJeon Bu-NamKoh Dong-InKim Kyung-SupPark So-YoonYun Chae-OkHur Man-Wook