POU6F2 antibody - N-terminal region (ARP31534_P050)
- Known as:
- POU6F2 (anti-) - N-terminal region (ARP31534_P050)
- Catalog number:
- arp31534_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- POU6F2 antibody - N-terminal region (ARP31534_P050)
Related genes to: POU6F2 antibody - N-terminal region (ARP31534_P050)
- Gene:
- POU6F2 NIH gene
- Name:
- POU class 6 homeobox 2
- Previous symbol:
- -
- Synonyms:
- RPF-1
- Chromosome:
- 7p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-29
- Date modifiied:
- 2014-11-18
Related products to: POU6F2 antibody - N-terminal region (ARP31534_P050)
Related articles to: POU6F2 antibody - N-terminal region (ARP31534_P050)
- Neural circuits in the spinal cord are composed of diverse populations of interneurons that play crucial roles in shaping motor output. However, the extent of interneuron heterogeneity and how this diversity relates to functional aspects of movement remain unclear. Here, through a focus on mouse spinal V1 interneurons, we show that loss of the V1 transcription factor En1 selectively disrupts the frequency of rhythmic locomotor output but does not disrupt flexion/extension limb movement, thereby decoupling two key functional roles ascribed to this neuronal population. To investigate the cellular basis of these deficits, we generated a single-nucleus transcriptomic atlas of V1 interneurons across postnatal development. Our analysis reveals age-dependent transcriptional changes while also demonstrating that their core molecular taxonomy perdures into adulthood. Notably, En1 deficiency selectively perturbed a single subset of V1 interneurons, thereby identifying a possible cellular substrate for influencing locomotor speed. Beyond serving as a molecular resource, our study highlights how deep neuronal profiling provides an entry point for understanding the multifunctional nature of heterogeneous interneuron populations. - Source: PubMed
Publication date: 2026/08/10
Trevisan Alexandra JHan KatieChapman Phillip DKulkarni Anand SHinton Jennifer MKlein InesRamirez CodyLavado AlfonsoGatto GrazianaGabitto Mariano IMenon VilasBikoff Jay B - The contribution of retinal ganglion cells (RGCs) subtypes to visually guided behavior continues to be an active area of research. We identify POU6F2-expressing RGCs that are ON-OFF direction-selective RGCs and are vulnerable to glaucomatous injury. In knockout ( ) mice, there is a 12% loss of RGCs, and these cells are the POU6F2-expressing RGCs. Functionally, mice exhibited profound deficit in contrast sensitivity. In the present study, we demonstrate a significant decline in the ability of mice to perform a predation test that is dependent on binocular vision. Wild-type mice detect and capture the cricket rapidly; while mice require a significantly longer time to complete the task. After optic nerve crush, wildtype mice require a longer time to capture crickets; while there is no further impairment in the mice. These data demonstrate that the POU6F2-positive RGCs are essential for this binocularly driven behavior. - Source: PubMed
Publication date: 2026/07/31
Lin FangyuLin Su-TingGeisert Eldon E - Cancer stem cells (CSC) and the immunosuppressive microenvironments are key drivers of breast cancer (BC) progression and drug resistance. However, the molecular mechanisms by which One Cut Homeobox 2 (ONECUT2) governs CSC and the tumor immune microenvironment (TIME) remain largely unknown. Given the critical knowledge gap, we sought to investigate ONECUT2's regulatory impact on CSC properties and TIME profiles using BC cell lines, animal models, and clinical specimens. Here, we demonstrated that inhibition of ONECUT2, a core transcription factor, potently drives CSC characteristics and reprograms the TIME to favor macrophage polarization to the M2-type, a tumor-promoting state. Mechanistically, ONECUT2 inhibition transcriptionally activated POU6F2, which subsequently triggered beta-catenin, thereby enhancing CSC properties and chemoresistance in BC. With respect to modulating the immune microenvironment, suppression of ONECUT2 governs macrophage polarization toward the immunosuppressive M2 phenotype. CCL28 is identified as a transcriptional target of ONECUT2 required for M2-type macrophage polarization, and CCR10 as a key receptor involved in this immune modulation. These findings highlight the critical involvement of ONECUT2 in modulating BC stemness via targeting the POU6F2-beta-catenin axis and managing macrophage polarization to M2 phenotype through the CCL28-CCR10 pathway. Our study suggests that ONECUT2 modulates cancer stemness and the TIME, and that targeting its downstream POU6F2-beta-catenin axis and CCL28-CCR10 pathway may provide an effective approach for BC treatment. - Source: PubMed
Publication date: 2026/06/02
Shen MengJin HaixiaHuang ZiqiDong NanLiu GenZeng YuMeng YuanLiu YumengYang LiliRen Xiubao - Retinal ganglion cells (RGCs) are the principal conduits responsible for propagating visual stimuli from the retina to visual centers in the brain. The loss of RGCs leads to visual deficits following trauma or in diseases such as glaucoma. Mouse models are consistently used to investigate root causes for RGC loss. This study quantifies the total number of RGCs and selected RGC subtypes across six strains of inbred mice used in ophthalmic research. - Source: PubMed
Publication date: 2026/02/20
Lin Su-TingLin FangyuWang JiaxingGeisert Eldon E - The contribution of retinal ganglion cells (RGCs) subtypes to visually guided behavior continues to be an active area of research. We identify POU6F2-expressing RGCs essential for binocular predatory behavior. The POU6F2 RGCs are ON-OFF direction-selective RGCs that are vulnerable to glaucomatous injury. In knockout ( ) mice, there is a 12% loss of RGCs, and these cells are the POU6F2-expressing RGCs. Functionally, mice exhibited profound deficits in contrast sensitivity. In this study we found a deficit in the ability of mice to perform a binocularly driven cricked predation test. Wildtype mice detect and capture the cricket rapidly; while, both mice and mice with one optic nerve crushed, required significant longer times to complete the task. After optic nerve crush no further impairment in performance is seen in the knockout mouse. These data demonstrate that the POU6F2-positive RGCs are essential for this binocularly driven behavior. - Source: PubMed
Publication date: 2026/03/18
Lin FangyuLin Su-TingGeisert Eldon E