CDX4 antibody - middle region (ARP31478_P050)
- Known as:
- CDX4 (anti-) - middle region (ARP31478_P050)
- Catalog number:
- arp31478_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CDX4 antibody - middle region (ARP31478_P050)
Related genes to: CDX4 antibody - middle region (ARP31478_P050)
- Gene:
- CDX4 NIH gene
- Name:
- caudal type homeobox 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xq13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-06-14
- Date modifiied:
- 2014-11-18
Related products to: CDX4 antibody - middle region (ARP31478_P050)
Related articles to: CDX4 antibody - middle region (ARP31478_P050)
- The SNPs in the 5' regulatory region of the human RGS4 gene were reportedly associated with schizophrenia risk. - Source: PubMed
Publication date: 2026/08/01
Xu Feng-LingYang Xin-RuiYang Yan-YanWang Rong-ShuaiLiu Li - During zebrafish embryonic body elongation, differentiation of mesodermal progenitors into presomitic mesoderm requires the transcription factors tbx16 and mesogenin 1. Here, by using temporally controlled tbx16 and mesogenin 1 overexpression and RNAseq to identify immediate downstream changes in gene expression, we elucidate how these genes promote presomitic mesoderm differentiation. Using machine learning and game theory, we integrated differentially expressed genes with wild-type scRNAseq data and identified genes downstream of tbx16 and mesogenin 1 during mesoderm differentiation. This data-driven analysis indicates that mesogenin 1 and tbx16 primarily repress expression of genes as mesodermal progenitors differentiate. Strikingly, the genes that are most important for defining transcriptional cell states during mesoderm differentiation are most strongly repressed by tbx16 and mesogenin 1. Moreover, these downstream effectors are enriched for genes with known roles in mesoderm development and body elongation such as Fgf, Wnt and Bmp pathways and the transcription factors tbxta, eve1, hoxd12a, hoxd13b, lef1, cdx4, tbx16l, ved, vent and vox. Gradients of Fgf and Wnt specify the mesodermal progenitor state in the posterior tailbud and activate many of these transcription factors indicating that tbx16 and mesogenin 1 promote mesoderm differentiation by repressing this progenitor state. - Source: PubMed
Publication date: 2026/06/08
Zhu GuoyuGenuth Miriam AXiao YanrongKindberg Abigail AHackett KayleighHolley Scott A - Two new three-dimensional organic-inorganic hybrid crystalline materials, [(Ade) CdCl] () and [(Ade) CdBr] (), were obtained by the slow evaporation of adenine (Ade) and cadmium chloride in aqueous solution at room temperature with hydrochloric acid and hydrobromic acid used as halogen sources. The structural, thermal, optical, and electrical properties were characterized by single-crystal X-ray diffraction, infrared spectroscopy, thermogravimetric analysis, variable-temperature-variable-frequency dielectric constant analysis, and electrochemical tests. With increasing the substitution of Cl by Br, the composition of the material changed and the space group shifted from -1 to 2/m, with a significant blue-shift in the fluorescence emission. Changing the temperature induced the deformation of the three-dimensional framework structure formed by hydrogen bonding interactions, leading to dielectric anomalies. Cyclic voltammetry tests showed the good reversibility of the electrolysis process. The structural diversity of the complexes was realized by modulating the halogen composition, and a new method for designing novel organic-inorganic hybrids with controllable photoelectric functionality was proposed. - Source: PubMed
Publication date: 2024/06/11
Lv MeixiaHu HongzhiAdila AbuduheniYan YiboLiu YangLiu Zunqi - Acute Erythroid Leukemia (AEL) is a rare and aggressive subtype of Acute Myeloid Leukemia (AML). In 2022, the World Health Organization (WHO) defined AEL as a biopsy with ≥30% proerythroblasts and erythroid precursors that account for ≥80% of cellularity. The International Consensus Classification refers to this neoplasm as "AML with mutated ". Classification entails ≥20% blasts in blood or bone marrow biopsy and a somatic mutation (VAF > 10%). This type of leukemia is typically associated with biallelic mutations and a complex karyotype, specifically 5q and 7q deletions. Transgenic mouse models have implicated several molecules in the pathogenesis of AEL, including transcriptional master regulator GATA1 (involved in erythroid differentiation), master oncogenes, and CDX4. Recent studies have also characterized AEL by epigenetic regulator mutations and transcriptome subgroups. AEL patients have overall poor clinical outcomes, mostly related to their poor response to the standard therapies, which include hypomethylating agents and intensive chemotherapy. Allogeneic bone marrow transplantation (AlloBMT) is the only potentially curative approach but requires deep remission, which is very challenging for these patients. Age, AlloBMT, and a history of antecedent myeloid neoplasms further affect the outcomes of these patients. In this review, we will summarize the diagnostic criteria of AEL, review the current insights into the biology of AEL, and describe the treatment options and outcomes of patients with this disease. - Source: PubMed
Publication date: 2024/06/06
Fernandes PriyankaWaldron NatalieChatzilygeroudi TheodoraNaji Nour SabihaKarantanos Theodoros - Improving the egg production of goose is a crucial goal of breeding, because genetics is the key factor affecting egg production. Thus, we sequenced the genomes of 55 Chinese indigenous geese from six breeds, which were divided into the high egg-laying group (ZE, HY, and SC) and low egg-laying group (ZD, LH, and ST). Based on the results of the inter-population selection signal analysis, we mined the selected genome regions in the high egg-laying germplasm population to identify the key candidate genes affecting the egg-laying traits. - Source: PubMed
Publication date: 2023/12/06
Zhao HongchangSun GuoboMu XiaohuiLi XiaomingWang JunZhao MengliZhang GanshengJi RongchaoChen ChaoGao GuangliangWang Jian