CDX4 antibody - middle region (ARP31478_P050)
- Known as:
- CDX4 (anti-) - middle region (ARP31478_P050)
- Catalog number:
- arp31478_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CDX4 antibody - middle region (ARP31478_P050)
Related genes to: CDX4 antibody - middle region (ARP31478_P050)
- Gene:
- CDX4 NIH gene
- Name:
- caudal type homeobox 4
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xq13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-06-14
- Date modifiied:
- 2014-11-18
Related products to: CDX4 antibody - middle region (ARP31478_P050)
Related articles to: CDX4 antibody - middle region (ARP31478_P050)
- : Male factors account for approximately 30-50% of subfertile couples. Teratozoospermia is one of the major causes of male infertility; however, the genetic factors underlying many cases remain incompletely understood. This study aimed to identify potential genetic variants associated with teratozoospermia and to investigate the possible involvement of Caudal-Type Homeobox 4 (CDX4) in sperm morphogenesis. : Whole-exome sequencing was performed in 44 individuals with teratozoospermia. A rare variant (NM_005193.2, c.103G>T; NP_005184.1, Gly35Cys) was identified and confirmed by Sanger sequencing. Because is located on the X chromosome, this variant was interpreted as hemizygous in the male patient. Sperm morphology, CDX4 localization, public GEO transcriptomic data (GSE6969), and CDX4 expression during murine spermiogenesis were analyzed. : The CDX4 p.Gly35Cys variant is located within the Caudal-like transactivation domain, a conserved region involved in transcriptional regulation. Spermatozoa from the patient carrying this variant exhibited severe morphological abnormalities, predominantly involving sperm-head defects, together with aberrant CDX4 localization along the midpiece and tail, in contrast to the neck- and annulus-enriched distribution observed in control spermatozoa. Reanalysis of the GEO dataset showed increased CDX4 transcript levels in teratozoospermic samples compared with normozoospermic controls. During murine spermiogenesis, CDX4 was detected in the nuclei of spermatogonia and spermatocytes and subsequently localized to the sperm head and neck/tail regions during sperm morphogenesis. : c.103G>T (p.Gly35Cys) is a rare hemizygous X-linked candidate variant associated with severe teratozoospermia in a single patient. Further cohort-based, segregation, and functional studies are required to clarify its role in sperm morphogenesis. - Source: PubMed
Publication date: 2026/08/05
Au Chin-FongWang Ya-YunLai Tsung-HsuanChan Chying-ChyuanKe Chih-ChunChung Shiu-DongLin Ying-Hung - The SNPs in the 5' regulatory region of the human RGS4 gene were reportedly associated with schizophrenia risk. - Source: PubMed
Publication date: 2026/08/01
Xu Feng-LingYang Xin-RuiYang Yan-YanWang Rong-ShuaiLiu Li - During zebrafish embryonic body elongation, differentiation of mesodermal progenitors into presomitic mesoderm requires the transcription factors tbx16 and mesogenin 1. Here, by using temporally controlled tbx16 and mesogenin 1 overexpression and RNAseq to identify immediate downstream changes in gene expression, we elucidate how these genes promote presomitic mesoderm differentiation. Using machine learning and game theory, we integrated differentially expressed genes with wild-type scRNAseq data and identified genes downstream of tbx16 and mesogenin 1 during mesoderm differentiation. This data-driven analysis indicates that mesogenin 1 and tbx16 primarily repress expression of genes as mesodermal progenitors differentiate. Strikingly, the genes that are most important for defining transcriptional cell states during mesoderm differentiation are most strongly repressed by tbx16 and mesogenin 1. Moreover, these downstream effectors are enriched for genes with known roles in mesoderm development and body elongation such as Fgf, Wnt and Bmp pathways and the transcription factors tbxta, eve1, hoxd12a, hoxd13b, lef1, cdx4, tbx16l, ved, vent and vox. Gradients of Fgf and Wnt specify the mesodermal progenitor state in the posterior tailbud and activate many of these transcription factors indicating that tbx16 and mesogenin 1 promote mesoderm differentiation by repressing this progenitor state. - Source: PubMed
Publication date: 2026/06/08
Zhu GuoyuGenuth Miriam AXiao YanrongKindberg Abigail AHackett KayleighHolley Scott A - Two new three-dimensional organic-inorganic hybrid crystalline materials, [(Ade) CdCl] () and [(Ade) CdBr] (), were obtained by the slow evaporation of adenine (Ade) and cadmium chloride in aqueous solution at room temperature with hydrochloric acid and hydrobromic acid used as halogen sources. The structural, thermal, optical, and electrical properties were characterized by single-crystal X-ray diffraction, infrared spectroscopy, thermogravimetric analysis, variable-temperature-variable-frequency dielectric constant analysis, and electrochemical tests. With increasing the substitution of Cl by Br, the composition of the material changed and the space group shifted from -1 to 2/m, with a significant blue-shift in the fluorescence emission. Changing the temperature induced the deformation of the three-dimensional framework structure formed by hydrogen bonding interactions, leading to dielectric anomalies. Cyclic voltammetry tests showed the good reversibility of the electrolysis process. The structural diversity of the complexes was realized by modulating the halogen composition, and a new method for designing novel organic-inorganic hybrids with controllable photoelectric functionality was proposed. - Source: PubMed
Publication date: 2024/06/11
Lv MeixiaHu HongzhiAdila AbuduheniYan YiboLiu YangLiu Zunqi - Acute Erythroid Leukemia (AEL) is a rare and aggressive subtype of Acute Myeloid Leukemia (AML). In 2022, the World Health Organization (WHO) defined AEL as a biopsy with ≥30% proerythroblasts and erythroid precursors that account for ≥80% of cellularity. The International Consensus Classification refers to this neoplasm as "AML with mutated ". Classification entails ≥20% blasts in blood or bone marrow biopsy and a somatic mutation (VAF > 10%). This type of leukemia is typically associated with biallelic mutations and a complex karyotype, specifically 5q and 7q deletions. Transgenic mouse models have implicated several molecules in the pathogenesis of AEL, including transcriptional master regulator GATA1 (involved in erythroid differentiation), master oncogenes, and CDX4. Recent studies have also characterized AEL by epigenetic regulator mutations and transcriptome subgroups. AEL patients have overall poor clinical outcomes, mostly related to their poor response to the standard therapies, which include hypomethylating agents and intensive chemotherapy. Allogeneic bone marrow transplantation (AlloBMT) is the only potentially curative approach but requires deep remission, which is very challenging for these patients. Age, AlloBMT, and a history of antecedent myeloid neoplasms further affect the outcomes of these patients. In this review, we will summarize the diagnostic criteria of AEL, review the current insights into the biology of AEL, and describe the treatment options and outcomes of patients with this disease. - Source: PubMed
Publication date: 2024/06/06
Fernandes PriyankaWaldron NatalieChatzilygeroudi TheodoraNaji Nour SabihaKarantanos Theodoros