HMG20A antibody - N-terminal region (ARP31471_P050)
- Known as:
- HMG20A (anti-) - N-terminal region (ARP31471_P050)
- Catalog number:
- arp31471_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- HMG20A antibody - N-terminal region (ARP31471_P050)
Related genes to: HMG20A antibody - N-terminal region (ARP31471_P050)
- Gene:
- HMG20A NIH gene
- Name:
- high mobility group 20A
- Previous symbol:
- -
- Synonyms:
- HMGX1, FLJ10739, HMGXB1
- Chromosome:
- 15q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-11
- Date modifiied:
- 2016-10-05
Related products to: HMG20A antibody - N-terminal region (ARP31471_P050)
Related articles to: HMG20A antibody - N-terminal region (ARP31471_P050)
- The Xinjiang Black pig is an excellent breed developed by the Xinjiang Production and Construction Corps in the 1990s; however, it has been endangered by the impact of commercial breeds. Whole genomes of 224 individuals from the Xinjiang Black pig conservation population were resequenced. Genetic structure and diversity analyses revealed that Xinjiang Black pigs underwent severe inbreeding and were genetically closely linked to Landrace pigs. The genetic diversity of the F generation was well preserved in the existing breeding scheme. A total of 686 significant selection regions and 406 candidate genes were identified using and θπ complementary methods, with Xinjiang Black pigs, Min pigs, and Laiwu pigs as ancestral populations, and F. Based on Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and quantitative trait loci annotations, potential germplasm candidate genes were identified. Among these, , , and are associated with fat deposition; , , , and are closely associated with male reproductive ability; and are strongly associated with oestrous cycle regulation and oocyte maturation; and and are extremely important for osmotic regulation and foetal survival. These findings deepen our understanding of the genetic mechanisms of artificial selection in Xinjiang Black pigs and provide a theoretical basis for subsequent breeding and genetic research on this breed. - Source: PubMed
Publication date: 2026/02/28
Tian MingmingFeng YunWang HaitaoWang QiangDong JingyangZhao HaichaoYang FahuiLi MengxunPu GuangZhang XinyinWang DanLi GuangChen HongweiHuang Tao - Neurodevelopmental disorders (NDDs) affect approximately 15% of children and adolescents worldwide. This group of disorders is often polygenic with varying risk factors, with many associated genes converging on shared molecular pathways, including chromatin regulation and transcriptional control. Understanding how NDD-associated chromatin regulators and protein complexes orchestrate these regulatory pathways is crucial for elucidating NDD pathogenesis and developing targeted therapeutic strategies. Recently, the TCF20/PHF14 chromatin complex was identified in the mammalian brain, expanding the list of chromatin regulatory remodelers implicated in NDDs. This complex-which includes MeCP2, RAI1, TCF20, PHF14, and HMG20A-plays a vital role in epigenetic and transcriptional regulation. - Source: PubMed
Publication date: 2024/12/23
Dominguez GaeaWu YongjiZhou Jian - Type 2 diabetes mellitus leads to debilitating complications that affect the quality of life of many Filipinos. Genetic variability contributes to 30% to 70% of T2DM risk. Determining genomic variants related to type 2 diabetes mellitus susceptibility can lead to early detection to prevent complications. However, interethnic variability in risk and genetic susceptibility exists. This study aimed to identify variants associated with type 2 diabetes mellitus among Filipinos using a case-control design frequency matched for age and sex. A comparison was made between 66 unrelated Filipino adults with type 2 diabetes mellitus and 121 without. Genotyping was done using a candidate gene approach on genetic variants of type 2 diabetes mellitus and its complications involving allelic association and genotypic association studies with correction for multiple testing. Nine (9) significant variants, mostly involved in glucose and energy metabolism, associated with type 2 diabetes mellitus in Filipinos were found. Notably, a CDKAL1 variant (rs7766070) confers the highest level of risk while rs7119 (HMG20A) and rs708272 (CETP) have high risk allele frequencies in this population at 0.77 and 0.66, respectively, making them potentially good markers for type 2 diabetes mellitus screening. The data generated can be valuable in developing genetic risk prediction models for type 2 diabetes mellitus to diagnose and prevent the condition among Filipinos. - Source: PubMed
Publication date: 2024/11/19
C Cutiongco-de la Paz Eva MariaNevado Jose BPaz-Pacheco Elizabeth TJasul Gabriel VAman Aimee Yvonne Criselle LFrancisco Mark David G - The evolutionarily conserved histone variant H2A.Z plays a crucial role in various DNA-based processes, but the mechanisms underlying its activity are not completely understood. Recently, we identified the zinc finger (ZF) protein ZNF512B as a protein associated with H2A.Z, HMG20A and PWWP2A. Here, we report that high levels of ZNF512B expression lead to nuclear protein and chromatin aggregation foci that form in a manner that is dependent on the ZF domains of ZNF512B. Notably, we demonstrate ZNF512B binding to the nucleosome remodeling and deacetylase (NuRD) complex. We discover a conserved amino acid sequence within ZNF512B that resembles the NuRD-interaction motif (NIM) previously identified in FOG-1 and other transcriptional regulators. By solving the crystal structure of this motif bound to the NuRD component RBBP4 and by applying several biochemical and biophysical assays, we demonstrate that this internal NIM is both necessary and sufficient for robust and high-affinity NuRD binding. Transcriptome analyses and reporter assays identify ZNF512B as a repressor of gene expression that can act in both NuRD-dependent and -independent ways. Our study might have implications for diseases in which ZNF512B expression is deregulated, such as cancer and neurodegenerative diseases, and hints at the existence of more proteins as potential NuRD interactors. - Source: PubMed
Wunderlich Tim MariusDeshpande ChandrikaPaasche Lena WFriedrich TobiasDiegmüller FelixHaddad EliasKreienbaum CarlottaNaseer HaniyaStebel Sophie EDaus NadineLeers JörgLan JieTrinh Van TuanVázquez OlallaButter FalkBartkuhn MarekMackay Joel PHake Sandra B - Frequent recurrence and metastasis caused by cancer stem cells (CSCs) are major challenges in lung cancer treatment. Therefore, identifying and characterizing specific CSC targets are crucial for the success of prospective targeted therapies. In this study, it is found that upregulated TOR Signaling Pathway Regulator-Like (TIPRL) in lung CSCs causes sustained activation of the calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) signaling pathway by binding to CaMKK2, thereby maintaining stemness and survival. CaMKK2-mediated activation of CaM kinase 4 (CaMK4) leads to phosphorylation of cAMP response element-binding protein (CREB) at Ser129 and Ser133, which is necessary for its maximum activation and the downstream constitutive expression of its target genes (Bcl2 and HMG20A). TIPRL depletion sensitizes lung CSCs to afatinib-induced cell death and reduces distal metastasis of lung cancer in vivo. It is determined that CREB activates the transcription of TIPRL in lung CSCs. The positive feedback loop consisting of CREB and TIPRL induces the sustained activation of the CaMKK2-CaMK4-CREB axis as a driving force and upregulates the expression of stemness- and survival-related genes, promoting tumorigenesis in patients with lung cancer. Thus, TIPRL and the CaMKK2 signaling axis may be promising targets for overcoming drug resistance and reducing metastasis in lung cancer. - Source: PubMed
Publication date: 2024/07/30
Song In-SungJeong Yu-JeongYun Jae KwangLee JiminYang Hae-JunPark Young-HoKim Sun-UkHong Seung-MoLee Peter C WLee Geun DongJang Sung-Wuk