NFKBIA Antibody - N-terminal region (ARP30301_P050)
- Known as:
- NFKBIA Antibody - N-terminal region (ARP30301_P050)
- Catalog number:
- arp30301_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- NFKBIA Antibody - N-terminal region (ARP30301_P050)
Related genes to: NFKBIA Antibody - N-terminal region (ARP30301_P050)
- Gene:
- NFKBIA NIH gene
- Name:
- NFKB inhibitor alpha
- Previous symbol:
- NFKBI
- Synonyms:
- IKBA, MAD-3, IkappaBalpha
- Chromosome:
- 14q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2019-04-23
Related products to: NFKBIA Antibody - N-terminal region (ARP30301_P050)
Related articles to: NFKBIA Antibody - N-terminal region (ARP30301_P050)
- A major technical challenge in single-cell transcriptomics is the absence of an integrative analytic pipeline that can simultaneously leverage gene regulatory network (GRN) architecture, AI-assisted gene panel discovery, and functional relevance analyses to generate coherent biological insights. Existing approaches often treat these components independently, focusing on clusters, marker genes, or predictive features without integrating them into a mechanistically grounded framework. Consequently, comprehensive screening that links regulatory association, gene signature screening, and functional interpretation within single-cell datasets remains limited, underscoring the need for an integrated strategy. - Source: PubMed
Publication date: 2026/04/06
Borra SantoshiYan DaWelner Robert SYue Zongliang - Polyserositis is an important clinical feature of (, GPS) infection in pigs, typically presenting as peritonitis, pleuritis, pericarditis, meningitis, and arthritis, resulting in heavy economic losses in the swine industry. However, the current research on the pathogenesis of infectious peritonitis, particularly that caused by GPS, remains limited, and this condition has long been poorly reported in both clinical practice and research. In this study, we investigated the overall changes in gene expression in porcine peritoneal mesothelial primary cells (PPMCs) following a GPS infection using transcriptomics analysis. A total of 779 differentially expressed genes (DEGs) were identified after 12 h of infecting the PPMCs with GPS, resulting in 253 and 526 genes being upregulated and downregulated, respectively. Additionally, 220 DEGs, mainly involved in the NOD-like receptor signaling pathway, the TNF signaling pathway, and the metabolic pathway, were enriched in the KEGG analysis. These pathways were associated with the main DEGs (IL-1β, IL6, CCL5, CCL2 and NFKBIA), and their gene expression levels were verified through quantitative real-time fluorescence PCR (qRT-PCR). Moreover, oxidative phosphorylation, Salmonella infection, rheumatoid arthritis, and other regulating pathways were clustered together. Our results provide insights into the molecular mechanism underlying GPS-induced peritonitis in swine, identify novel therapeutic targets, and provide research direction for the control and prevention of GPS infections. These insights provide a foundational basis for advancing intervention and prevention approaches for this overlooked yet clinically significant manifestation of polyserositis. - Source: PubMed
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Campana IreneMinafò Ylenia AuraScaglione Giovanni LucaGiovanardi GiuliaCosio TerenzioLanna CaterinaArtosi FabioLambiase SaraValente CarolaBartolocci ValeriaMorelli MartinaAlbanesi CristinaPalese EnzoMinieri MarilenaGiovannelli AlfredoAvitabile DanieleSalcedo Nidia MargotMastroeni SimonaMazzanti CinziaAbeni DamianoCampione ElenaFania LucaDellambra Elena - Psychedelics such as psilocybin are known for their hallucinogenic properties and have also been reported to produce long-lasting therapeutic effects in depression and possibly also other psychiatric disorders. Several lines of evidence suggest that psilocybin exerts its effects through activation of 5-HT2A receptors located postsynaptically to serotonergic neurons, e.g., in the frontal cortex, parts of the limbic system, including the amygdala and hippocampus, and striatum. The present study was conducted to shed further light on psilocybin-induced changes in gene expression. - Source: PubMed
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