Cdk5r1 antibody - C-terminal region (ARP30200_P050)
- Known as:
- Cdk5r1 (anti-) - C-terminal region (ARP30200_P050)
- Catalog number:
- arp30200_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- Cdk5r1 antibody - C-terminal region (ARP30200_P050)
Related genes to: Cdk5r1 antibody - C-terminal region (ARP30200_P050)
- Gene:
- CDK5R1 NIH gene
- Name:
- cyclin dependent kinase 5 regulatory subunit 1
- Previous symbol:
- -
- Synonyms:
- p35nck5a, Nck5a, p35
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-08
- Date modifiied:
- 2016-10-05
Related products to: Cdk5r1 antibody - C-terminal region (ARP30200_P050)
Related articles to: Cdk5r1 antibody - C-terminal region (ARP30200_P050)
- In traditional Chinese medicine (TCM), oxaliplatin-induced peripheral neuropathy (OIPN) is understood as a manifestation of "blood impediment" and "flaccidity" syndromes caused by blood deficiency and cold stagnation in the meridians. Danggui Sini Decoction (a well-known warming formula composed of seven herbs: Danggui, Guizhi, Baishao, Xixin, Gancao, Tongcao, and Dazao) is specifically indicated for these patterns. It works by nourishing blood and warming the meridians, and has been used clinically to alleviate OIPN. However, modern processing methods such as ethanol precipitation may remove insoluble components (e.g., polysaccharides), raising concerns regarding potential efficacy loss. - Source: PubMed
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Qin Xiang-LingLv Hu-DongYang QiJin Bi-XiaGe JingWu Ke-XuanHuo Jie-GeYao NanLi Song-LinZhu HeZhou Jing - Excessive dieting (ED), a common weight-control strategy, often causes neurological and emotional disturbances, yet its gut-brain interaction mechanisms remain unclear. Employing a short-term dietary (SDR) adult male rabbit model, we found that SDR can induced cerebral cortex up-regulation of the immune-related genes (e.g., C1QC, SAA3) enriched in NF-kappa B signaling pathways, contrasted with down-regulation of sex hormone-related genes (e.g., PRLR, SPA17) implicated in metabolic homeostasis. Furthermore, dysregulated expression of metabolic genes (e.g., PPM1J, GALNT18) in the cecum of the SDR group interacted to impair the immune protection pathways related to intestinal mucosa. Then, SDR significantly increased the cecal Firmicutes/Bacteroidetes ratio (from 3.38 to 5.57) and reduced microbial diversity. Specifically, beneficial bacteria involved in tryptophan metabolism and neurotransmitter synthesis (e.g., Bacteroidales_bacterium, Alistipes_indistinctus) decreased, whereas bile acid-metabolizing bacteria (e.g., Clostridium_sp._CAG:710, Ruminococcus_sp._Marseille-P6503) linked to increase energy metabolism. The top 20 genes from the brain-gut axis analysis (e.g., ITPR1, CAMK4, CDK5R1) were enriched in critical neural pathways like axon guidance, GABAergic synapse, and long-term potentiation. Notably, key neurodevelopmental genes (e.g., GPR37, GPX3) correlated with these microbial shifts, implicating oxidative stress, synaptic plasticity, and mitochondrial function in microbiota-host crosstalk. This study highlights a "microbial-metabolism-neural" axis in SDR, providing novel targets for future obesity intervention strategies. - Source: PubMed
Publication date: 2025/12/08
Li YanhongChen JianningQi XiaolanHe YanWang GuozeWei LiminHong Wei - Depression is a prevalent mental disorder, with its incidence rising alongside the increasing pressures of modern social life. Although medications remain a cornerstone of treatment, first-line antidepressants are often associated with significant side effects. , a plant rich in isoflavonoid active ingredients, has demonstrated neuroprotective effects; however, the specific mechanisms behind its antidepressant components have not been fully elucidated. - Source: PubMed
Publication date: 2025/11/14
Li LiGao Jun-JieYan MinGuan LiQin Ming-MingYe KaiLi Tao - Macrophage polarization into M1 or M2 phenotypes is a complex process influenced by various factors. However, existing literature and ongoing research support the view that Cyclin-Dependent Kinase 5 (CDK5) may play an important role in this process. CDK5 is a protein kinase that requires association with regulatory, co-activating proteins, p35 (CDK5R1) or p39 (CDK5R2), for functional activation. - Source: PubMed
Publication date: 2025/09/17
Zampieri Juliana RChoi Sung HeeMyers Jay TTomchuck Suzanne LEid SaadaAskew DavidHuang Alex Y - The present manuscript explores the serum albumin interaction and target pathway analysis of a newly developed antifungal agent, 7-[2-(4-chlorophenyl) hydrazinylidene]-6-methyl-3-(pyridin-4-yl)-7H-[1, 2, 4]triazolo[3,4-b][1, 3, 4]thiadiazine (5E). Candida species are among the leading causes of systemic fungal infections, highlighting a need for new effective antifungal therapies because of drug resistance and associated side effects with existing treatment regimens. The synthesized compound (5E) demonstrated superior antifungal characteristics in comparison to ketaconazole, suggesting potential for more effective therapeutic options. Serum albumins in plasma binds and carries molecules, including drugs. Spectroscopic techniques, computational methods and target pathway analysis were employed for studying BSA-5E interactions. The compound 5E quenched BSA fluorescence via static quenching. The 5E primarily interacts with the IIA and IIIA subdomains of BSA which was aided by hydrogen binding. The target prediction tool of SwissADME predicted kinases, particularly CDK5R1, CDK5, PLK1, FLT1, KDR, and NTRK1, to be the most significant targets of 5E, followed by enzymes including lyases and oxidoreductases. GeneMANIA analysis identified key kinase-regulating lyases and oxidoreductase for carrying out antifungal action. The associated miRNAs were depicted by MIENTURNET providing insights into its pharmacokinetics and therapeutic potential at molecular level. Molecular docking aided to comprehend the BSA-5E interaction at protein level. - Source: PubMed
Publication date: 2025/09/23
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