ZNF394 antibody - N-terminal region (ARP30072_P050)
- Known as:
- ZNF394 (anti-) - N-terminal region (ARP30072_P050)
- Catalog number:
- arp30072_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF394 antibody - N-terminal region (ARP30072_P050)
Related genes to: ZNF394 antibody - N-terminal region (ARP30072_P050)
- Gene:
- ZNF394 NIH gene
- Name:
- zinc finger protein 394
- Previous symbol:
- -
- Synonyms:
- ZKSCAN14, FLJ12298, ZSCAN46
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-07-22
- Date modifiied:
- 2015-09-08
Related products to: ZNF394 antibody - N-terminal region (ARP30072_P050)
Related articles to: ZNF394 antibody - N-terminal region (ARP30072_P050)
- Fertilization involves fusion between sperm and metaphase II (MII) oocyte, initiating a cascade of events including oocyte activation, resumption of meiosis, formation and interdigitation of male and female pronuclei, and zygote formation. Total Fertilization Failure (TFF), characterized by the disruption of any of these processes, occurs in 1-3% of intracytoplasmic sperm injection (ICSI) cycles. The genetic basis of TFF remains largely unexplored. TFF can occur in cases where no single genetic cause is apparent, suggesting a potential polygenic contribution. - Source: PubMed
Publication date: 2025/11/04
Ata ManarChoucair FadiDjekidel Mohamed NadhirSousa Esteves MariaAl Ali FatimaNawaz ShoaibEl Taha LinaSoloviov OleksandrSathappan AbbiramiAliyev ElbayFakhro KhalidAwwad JohnnyAvella Matteo A - Parkinson's disease (PD) is a common neurodegenerative disorder. The role of protein post-translational modifications (PTMs), especially small ubiquitin-like modifier (SUMO) conjugation (SUMOylation), in PD pathogenesis remains unclear. This study aimed to investigate the relationship between SUMOylation and PD. - Source: PubMed
Publication date: 2025/08/08
Wei YifoZhang XinningZuo RuiDang WenxinChen LuLiu FanYao JiaRan WeizhengChen ZhigangWang XiaoyanLv FurongYu Yue - The initiation of major zygotic genome activation (ZGA) is crucial for human early embryogenesis. However, the transcription factors (TFs) regulating major ZGA in humans remain largely unknown. Here, we performed a CRISPR-based activation screen of 1,603 human TFs in human extended pluripotent stem cells (hEPSCs), which identified 132 candidates as potential regulators of major ZGA. Further evaluation of these candidates revealed that the KRAB-containing TFs ZIM3 and ZNF394 activated totipotent features in hEPSCs upon overexpression. Importantly, simultaneous knockdown of these two TFs arrested human embryo development prior to the eight-cell embryo stage. Mechanistically, the KRAB domains contributed to ZIM3- and ZNF394-mediated totipotency induction in vitro, accompanied by the suppression of a set of four-cell embryo enriched genes. Our study provided valuable resources for totipotency and major ZGA regulation, suggesting an un-reported role of KRAB-containing TFs in major ZGA in humans. - Source: PubMed
Publication date: 2025/07/15
Li JiayuXie LiangfuShi ChengZhang TiantianLin XiwenDa HaokunSun KongqianqianHan ChunshengZhu BingChen XiDeng HongkuiXu Jun - There is currently no formal consensus on the administration of adjuvant chemotherapy to stage I lung squamous cell carcinoma (LUSC) patients despite the poor prognosis. The side effects of adjuvant chemotherapy need to be balanced against the risk of tumour recurrence. Prognostic markers are thus needed to identify those at higher risks and recommend individualised treatment regimens. - Source: PubMed
Publication date: 2021/05/24
Wang KLi YWang JChen RLi J - Zinc finger proteins play important roles in a variety of cellular functions, including cell growth, proliferation, apoptosis, and intracellular signal transduction, and the zinc finger-containing transcription factor has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. With the aim of identifying the genes involved in human heart development and diseases, we have isolated a novel LER-related zinc finger gene named ZNF394 from human heart cDNA library. ZNF394 gene has a predicted 561-amino acid open reading frame, encoding a 64kDa zinc finger protein. The N-terminus of ZNF394 protein has a leucine-rich region (LER or SCAN domain), followed by a well-conserved krüppel-associated box domain. The C-terminus of the protein contains 7 C2H2 zinc finger motifs in tandem arrays with the highly conserved space region of the H/C-link. ZNF394 gene is mapped to chromosome 7q11.21. Northern blot analysis indicates that a 2.18kb transcript specific for ZNF394 is specifically expressed in the heart, skeletal muscle, and brain in human adult tissues. ZNF394 protein is expressed in cell nucleus. Overexpression of ZNF394 in the cell inhibits the transcriptional activities of c-Jun and AP-1 reporters, suggesting that ZNF394 is a new transcriptional repressor in mitogen-activated protein kinase signaling pathways and may play an important role in cardiac development and/or cardiac function. - Source: PubMed
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