UTF1 antibody - middle region (ARP30063_P050)
- Known as:
- UTF1 (anti-) - middle region (ARP30063_P050)
- Catalog number:
- arp30063_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- UTF1 antibody - middle region (ARP30063_P050)
Related genes to: UTF1 antibody - middle region (ARP30063_P050)
- Gene:
- UTF1 NIH gene
- Name:
- undifferentiated embryonic cell transcription factor 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-04
- Date modifiied:
- 2016-10-05
Related products to: UTF1 antibody - middle region (ARP30063_P050)
Related articles to: UTF1 antibody - middle region (ARP30063_P050)
- Gender affirming hormone therapy (GAHT) facilitates the desired phenotypic changes consistent with the individual's gender identity. However, inter-individual variability in treatment effects have been reported at endocrine and testicular tissue level. To address the hypothesis that treatment effects are not homogeneous, we selected 24 persons from a cohort of 453 persons assigned male at birth, based on a similar dose of cyproterone acetate (Androcur, 10 or 12.5 mg/day). Principal component analysis and hierarchical clustering on principal components was performed considering clinical parameters and identified four distinct clusters. Cluster 1 (n=3) was characterized by the presence of tubules with round or elongated spermatids, highest numbers of reserve spermatogonia (Adark) and cells positive for UTF1, PIWIL4, NANOS3, and KIT. Persons in Cluster 2 (n=4) showed a high percentage of tubules with spermatogonia as the most advanced germ cell type, and high testosterone levels, which were not suppressed to the desired female values. Persons in Cluster 3 (n=10) had low testosterone but elevated AMH levels and suppressed spermatogenesis to the spermatogonial level. Finally, persons in Cluster 4 (n=7) had the highest number of Sertoli cell only tubules and tubular shadows as well as highest person age. Despite homogenous inclusion criteria we observed heterogenous treatment effects. Consultation regarding contraceptives as well as fertility preservation therefore has to be considered in counselling ideally prior to initiation of GAHT. - Source: PubMed
Publication date: 2026/08/10
Schiwon KarenSieg FlorianSchneider FlorianHess JochenKliesch SabineSchlatt StefanDi Persio SaraNeuhaus Nina - Testicular development and spermatogenesis are critical for male reproduction, but their molecular mechanisms in Dezhou donkeys remain understudied. This study used single-cell RNA sequencing (scRNA-seq) to analyze testicular tissues from Dezhou donkeys at juvenile (2 months), pre-pubertal (12 months), and mature (24 months) stages. A total of 24,606 high-quality cells were profiled, constructing a comprehensive single-cell transcriptional atlas. Unsupervised clustering identified nine major cell types: three germ cell subtypes (spermatogonia, spermatocytes, spermatids) and six somatic cell subtypes (Leydig cells, Sertoli cells, peritubular muscle cells, macrophages, endothelial cells, T cells). Key marker genes (AMH, TNP1, UTF1, ZMYND10) were validated by immunofluorescence. Pseudotemporal trajectory analysis revealed sequential germ cell differentiation (spermatogonia → spermatocytes → spermatids) and Sertoli cell maturation (immature → mature), while Leydig cells and peritubular muscle cells shared common progenitors. CellChat analysis identified critical ligand-receptor pairs in BMP, IGF, WNT, and FSH pathways, which regulate testicular development. This study provides the comprehensive single-cell transcriptional map of Dezhou donkey testicular development, elucidating key molecular mechanisms of germ and somatic cell maturation. The findings offer valuable insights into donkey reproductive biology, supporting breeding improvement and male infertility research. - Source: PubMed
Publication date: 2026/05/26
Wang ZhaofeiYu JieLiu GuiqinJafari HalimaLi CongYang GeLei ChuzhaoDang Ruihua - Magnolia officinalis Rehder et Wilson (MRW) is a traditional herbal medicine with well-documented anti-inflammatory and antioxidative properties, yet its molecular basis in cancer therapy remains incompletely defined. This study aimed to elucidate the multi-target anticancer potential of MRW against pancreatic cancer through integrated in vitro and in silico analyses. LC-MS/MS profiling identified honokiol and magnolol as the major bioactive constituents, confirmed by retention time and UV spectra. MRW treatment suppressed cell viability and induced apoptosis in PANC-1 and MIA PaCa-2 cells by promoting reactive oxygen species (ROS) generation, mitochondrial membrane potential (∆Ψm) depolarization, and caspase activation, while sparing normal epithelial cells. Mechanistically, MRW inhibited DNA methyltransferase 1 (DNMT-1) and JAK2/STAT3 signaling while restoring undifferentiated embryonic cell transcription factor 1 (UTF-1) and miR-148a-3p expression, thereby reversing the epigenetic silencing and ROS overproduction characteristic of pancreatic cancer cells. Molecular docking further demonstrated strong binding affinities of honokiol, magnolol, and magnolin toward DNMT-1, UTF-1, STAT3, JAK2, IL-6, and Survivin, forming stable hydrogen-bond and π-π stacking interactions within catalytic pockets. These interactions suggest that MRW constituents' function as non-nucleoside DNMT-1 inhibitors and ROS-immune modulators that disrupt oncogenic feedback loops and re-activate apoptotic pathways. Collectively, these findings identify MRW as a multi-target phytomedicine integrating ROS-mediated oxidative stress, epigenetic remodeling, and immune-apoptotic signaling, supporting its translational potential as a low-toxicity adjunct strategy to conventional pancreatic cancer therapies. - Source: PubMed
Publication date: 2026/02/05
Choi JinwonLee Han-SaemKim Hyo JeongChoi MinTallei Trina EAhn Chi-HoonSo Jai-HyunPark Moon NyeoKim Bonglee - The epigenetic regulation of clustered protocadherin (cPCDH) genes is tightly linked to their function as specific cell surface barcodes for neural self-nonself discrimination. Differential cPCDH DNA methylation has been implicated in diverse neurological diseases as well as body weight, cancer and aging. However, the unique regulation of cPCDH methylation remains poorly understood. Therefore, we performed a genome-wide association study to evaluate the association of >7 million genetic variants with DNA methylation at 607 cPCDH CpGs measured in whole blood of 3777 individuals and validated findings in prefrontal cortex samples obtained from 523 brain donors. We observed concordant cPCDH methylation patterns in blood and prefrontal cortex, which switched between hypo-, intermediate and hypermethylation over short distances with the former overlapping with the promoter regions of each cPCDH member. Through methylation quantitative trait locus (meQTL) analysis in trans, we first confirmed the broad effect of the candidate gene SMCHD1 on cPCDH methylation in blood and then validated this effect in prefrontal cortex. Through a genome-wide analysis, we next identified the SENP7 and UTF1/VENTX loci to have widespread, subcluster-specific effects on cPCDH methylation in blood and brain. While SENP7 can indirectly affect DNA methylation through the deSUMOylation of the chromatin repressor KAP1, UTF1 and VENTX are two genes involved in embryonic development not previously implicated in epigenetic regulation. Our findings shed new light on the processes involved in cPCDH methylation that may underlie associations with neurological disease. - Source: PubMed
Publication date: 2025/10/02
Liu YunfengVukic MajaHannon EilisMei HailiangWalker EmmaSinke Lucy Mill JonathanDaxinger LuciaHeijmans Bastiaan T - Which spermatogonial differentiation states are present in prepubertal testes under normal conditions and following chemotherapy-induced depletion of spermatogonia in paediatric patients with cancer? - Source: PubMed
Ba Omar HajarStevens JustineHaavisto AnuCui YanhuaHarteveld FemkeYang YifanBjarnason RagnarRomerius PatrikSundin MikaelNyström Ulrika NorénLangenskiöld CeciliaVogt HartmutFrisk PerVepsäläinen KaisaPetersen CeciliaCui LinaGuo JingtaoJahnukainen KirsiStukenborg Jan-Bernd