ZNF503 antibody - middle region (ARP30022_P050)
- Known as:
- ZNF503 (anti-) - middle region (ARP30022_P050)
- Catalog number:
- arp30022_p050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- ZNF503 antibody - middle region (ARP30022_P050)
Related genes to: ZNF503 antibody - middle region (ARP30022_P050)
- Gene:
- ZNF503 NIH gene
- Name:
- zinc finger protein 503
- Previous symbol:
- -
- Synonyms:
- FLJ45745, MGC2555, Nlz2
- Chromosome:
- 10q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-04
- Date modifiied:
- 2016-10-05
- Gene:
- ZNF703 NIH gene
- Name:
- zinc finger protein 703
- Previous symbol:
- -
- Synonyms:
- FLJ14299, ZNF503L, NLZ1, Zpo1, ZEPPO1
- Chromosome:
- 8p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-16
- Date modifiied:
- 2016-11-01
Related products to: ZNF503 antibody - middle region (ARP30022_P050)
Related articles to: ZNF503 antibody - middle region (ARP30022_P050)
- The NET (for NocA, Nlz, Elbow, TLP-1) protein family is a group of conserved zinc finger proteins linked to embryonic development and recently associated with breast cancer. The members of this family act as transcriptional repressors interacting with both class I histone deacetylases and Groucho/TLE co-repressors. In Drosophila, the NET family members Elbow and NocA are vital for the development of tracheae, eyes, wings and legs, whereas in vertebrates ZNF703 and ZNF503 are important for the development of the nervous system, eyes and limbs. Despite the relevance of this protein family in embryogenesis and cancer, many aspects of its origin and evolution remain unknown. Here, we show that NET family members are present and expressed in multiple metazoan lineages, from cnidarians to vertebrates. We identified several protein domains conserved in all metazoan species or in specific taxonomic groups. Our phylogenetic analysis suggests that the NET family emerged in the last common ancestor of cnidarians and bilaterians and that several rounds of independent events of gene duplication occurred throughout evolution. Overall, we provide novel data on the expression and evolutionary history of the NET family that can be relevant to understanding its biological role in both normal conditions and disease. - Source: PubMed
Publication date: 2016/12/08
Pereira FilipeDuarte-Pereira SaraSilva Raquel Mda Costa Luís TeixeiraPereira-Castro Isabel - The gene networks underlying closure of the optic fissure during vertebrate eye development are poorly understood. Here, we profile global gene expression during optic fissure closure using laser capture microdissected (LCM) tissue from the margins of the fissure. From these data, we identify a unique role for the C(2)H(2) zinc finger proteins Nlz1 and Nlz2 in normal fissure closure. Gene knockdown of nlz1 and/or nlz2 in zebrafish leads to a failure of the optic fissure to close, a phenotype which closely resembles that seen in human uveal coloboma. We also identify misregulation of pax2 in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 act upstream of the Pax2 pathway in directing proper closure of the optic fissure. - Source: PubMed
Publication date: 2009/01/26
Brown Jacob DDutta SunitBharti KapilBonner Robert FMunson Peter JDawid Igor BAkhtar Amana LOnojafe Ighovie FAlur Ramakrishna PGross Jeffrey MHejtmancik J FieldingJiao XiaodongChan Wai-YeeBrooks Brian P - Members of the NET subfamily of zinc-finger proteins are related to the Sp-family of transcription factors and are required during embryogenesis. In particular, Nlz1/Znf703 and Nlz2/Znf503 are required for formation of rhombomere 4 of the vertebrate hindbrain. While NET family proteins have been hypothesized to regulate transcription, it remains unclear if they function as activators or repressors of transcription. - Source: PubMed
Publication date: 2008/11/12
Nakamura MakoChoe Seong-KyuRunko Alexander PGardner Paul DSagerström Charles G - This study describes the conserved nlz gene family whose members encode unusual zinc finger proteins. In the zebrafish neurectoderm, both nlz1 and the newly isolated nlz2 are expressed in the presumptive hindbrain and midbrain/hindbrain boundary, where expression of nlz1 is dependent on pax2a. In addition, nlz2 is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon. Overexpression of Nlz proteins during gastrula stages inhibits hindbrain development. In particular, ectopically expressed Nlz1 inhibits formation of future rhombomeres 2 and 3 (r2, r3), whereas neighboring r1 and r4 are not affected. Conversely, simultaneous reduction of Nlz1 and Nlz2 protein function by expression of antisense morpholino-modified oligomers leads to expansion of future r3 and r5, with associated loss of r4. These data indicate that one function of the nlz gene family is to specify or maintain r4 identity, and to limit r3 and r5 during hindbrain formation. - Source: PubMed
Hoyle JacquelineTang Yixin PWiellette Elizabeth LWardle Fiona CSive Hazel