GAS7 antibody - N-terminal region (ARP30004_T100)
- Known as:
- GAS7 (anti-) - N-terminal region (ARP30004_T100)
- Catalog number:
- arp30004_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- GAS7 antibody - N-terminal region (ARP30004_T100)
Related genes to: GAS7 antibody - N-terminal region (ARP30004_T100)
- Gene:
- GAS7 NIH gene
- Name:
- growth arrest specific 7
- Previous symbol:
- -
- Synonyms:
- KIAA0394, MGC1348
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-19
- Date modifiied:
- 2015-11-23
Related products to: GAS7 antibody - N-terminal region (ARP30004_T100)
Related articles to: GAS7 antibody - N-terminal region (ARP30004_T100)
- Cutaneous squamous cell carcinoma (cSCC) is a common and aggressive skin cancer, with treatment options for advanced stages often limited by chemoresistance. Here, we observe a positive correlation between PHF20 expression and the malignancy and tumor grade of cSCC. Functional studies suggest that PHF20 promotes oncogenic phenotypes, including proliferation, invasion, and epithelial-mesenchymal transition. Notably, PHF20 depletion appears to sensitize cSCC cells to chemotherapeutic agents. Mechanistically, we show that PHF20 interacts with and promotes the ubiquitin-mediated degradation of GAS7. This downregulation of GAS7 is associated with nuclear F-actin assembly, a process that has been implicated in DNA damage repair (DDR). Consequently, PHF20 loss stabilizes GAS7, enhances nuclear F-actin assembly, and is accompanied by increased DNA damage accumulation. These in vitro findings were corroborated in vivo, where PHF20 knockdown suppressed tumor growth and increased DNA damage. Together, PHF20 may contribute to the regulation of DDR and chemotherapeutic response, highlighting its potential as a therapeutic target in poorly differentiated cSCC. - Source: PubMed
Publication date: 2026/05/29
Li YunqianWen HeZheng HanZhen YunyueJia JingLi Zhengjun - Acute myocardial infarction (AMI) involves complex immune responses and cellular interaction mechanisms. Although the pathogenesis of AMI is now preliminarily understood, there is still a lack of biomarkers that can accurately and rapidly diagnose its disease characteristics. - Source: PubMed
Publication date: 2026/05/13
Liu ZhenfangSong JiaLi LinglingFan ZiyinXie GenyuanYang Li - Bladder cancer (BC) screening contributes to better patient outcomes. However, existing diagnostic methods for BC are not suitable for large-scale screening. Serum microRNAs (miRNAs) are expected to be simple, cost-effective, and non-invasive screening tools for BC. This study aims to identify whether relevant serum miRNAs as diagnostic markers for BC. - Source: PubMed
Publication date: 2026/01/26
Zhou HuimeiGe ZhenjianLin ShengjieWu YutongZhang PengwuLi XutaiZhao ZhengpingLai YongqingTao Lingzhi - are characterized by their ability to tolerate coarse feed, strong disease resistance, and delicious meat. Lower reproductive efficiency has become one of the key factors limiting its development. Therefore, this study investigated the developmental patterns of follicles and screened key candidate genes for in vitro experimental validation. Research collected granulosa cells from small follicles (<5 mm), medium (5-8 mm), and big (>8 mm), followed by RNA extraction for transcriptomic sequencing. A total of 20,775 genes were identified, including 13,777 (66.3%) differentially expressed genes (DEGs). DEGs showing up-regulation and down-regulated in B vs. S, B vs. M, and M vs. S groups were collected. A total of 19 commonly up-regulated DEGs across the three groups were identified, including genes such as , , and . Additionally, 227 commonly down-regulated DEGs were identified, including genes such as , , and . Protein interaction network analysis revealed an interaction between and . ovarian granulosa cells (GCs) were collected to investigate the effect of the on GCs proliferation. The results revealed that expression was highest in small follicles and was almost absent in big follicles. Subsequently, the gene was knocked down in GCs using small interfering RNA. RT-qPCR results demonstrated that both si-INSL3 (239) and si-INSL3 (392) significantly knock down expression ( < 0.01), si-INSL3 (239) for follow-up research. CCK-8 was used to assess cell proliferation, revealing that knockdown significantly enhanced GCs viability and number at 24, 48, and 72 h ( < 0.05). Flow cytometry was used to detect cell cycle distribution. The results showed that knockdown of expression significantly decreased the proportion of G1 phase cells and significantly increased the number of S phase cells ( < 0.01). RT-qPCR was used to detect the expression of cell proliferation-related genes. The results showed that compared with the siNC group, the expression levels of , , , and were significantly increased in the si-INSL3 group. In conclusion, knockdown of affects follicular development in by regulating granulosa cell proliferation in the ovaries, providing new insights into the regulatory mechanisms of follicular development in cattle. - Source: PubMed
Publication date: 2025/12/30
Li HongxianHe FenglouLi XinyeNie JunjieKhan Hasnain AliChen ChaoHua Jinling - Responsiveness to mood-stabilizing pharmacotherapy varies in bipolar disorder (BD). We investigated clinical correlates of second-generation antipsychotic (SGA) treatment response and conducted the first genome-wide association study (GWAS), including exploratory polygenic scores (PGS), of SGA pharmacogenomic treatment response in BD. - Source: PubMed
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Singh BalwinderHo Ada Man-ChoiCoombes Brandon JRomo-Nava FranciscoBond David JVeldic MarinPendegraft Richard SBatzler AnthonyCuellar-Barboza Alfredo BGardea-Reséndez ManuelPrieto Miguel LOzerdem AysegulMcElroy Susan LBiernacka Joanna MFrye Mark A