GAS7 antibody - N-terminal region (ARP30004_T100)
- Known as:
- GAS7 (anti-) - N-terminal region (ARP30004_T100)
- Catalog number:
- arp30004_t100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- GAS7 antibody - N-terminal region (ARP30004_T100)
Related genes to: GAS7 antibody - N-terminal region (ARP30004_T100)
- Gene:
- GAS7 NIH gene
- Name:
- growth arrest specific 7
- Previous symbol:
- -
- Synonyms:
- KIAA0394, MGC1348
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-19
- Date modifiied:
- 2015-11-23
Related products to: GAS7 antibody - N-terminal region (ARP30004_T100)
Related articles to: GAS7 antibody - N-terminal region (ARP30004_T100)
- Ketosis in dairy cows is characterized by elevated circulating β-hydroxybutyrate (BHBA) and profound alterations in whole-body energy metabolism. As a major peripheral tissue responsible for energy consumption and substrate utilization, skeletal muscle is continuously exposed to increased BHBA during ketosis and may use BHBA as an alternative energy substrate. However, the regulatory mechanism by which BHBA affects skeletal muscle differentiation remains unclear.This study used bovine skeletal muscle satellite cells (BMSCs) to investigate the effects of BHBA on the differentiation of BMSCs and to explore the regulatory roles of LNC297, miR-145, and GAS7 in this process. The results of dual-luciferase reporter gene assays and miRNA pull-down experiments verified the targeting relationship between LNC297, miR-145, and GAS7. BHBA inhibits the differentiation of BMSCs in a dose-dependent manner. Both LNC297 and GAS7 promote the differentiation of BMSCs and attenuate the inhibitory effect of BHBA. In contrast, miR-145 inhibits BMSCs differentiation and enhances the inhibitory effect of BHBA. Mechanistically, LNC297 acts as a competing endogenous RNA (ceRNA) or molecular sponge for miR-145, thereby upregulating GAS7 expression and promoting its differentiation function. LNC297 may promote muscle differentiation through the miR-145/GAS7 axis, thereby alleviating muscle damage in cows with ketosis, providing a new perspective for investigating the mechanisms of muscle development disorders. - Source: PubMed
Publication date: 2026/07/22
Tang TaoZhou JingJia XianboShao JiahaoWang MeiguiXia SiqiChen ShuaiSun WenqiangWang JieLai Song-Jia - Although controlled trials support several psychosocial interventions for adolescent internet gaming disorder (IGD), short, highly structured residential camp formats remain underreported, particularly regarding feasibility, safety, and process data from routine service settings. - Source: PubMed
Publication date: 2026/06/09
Yang ShanghaoZhou BojieXie YingfengHu YueyingShi LiZhou Xuhui - Cutaneous squamous cell carcinoma (cSCC) is a common and aggressive skin cancer, with treatment options for advanced stages often limited by chemoresistance. Here, we observe a positive correlation between PHF20 expression and the malignancy and tumor grade of cSCC. Functional studies suggest that PHF20 promotes oncogenic phenotypes, including proliferation, invasion, and epithelial-mesenchymal transition. Notably, PHF20 depletion appears to sensitize cSCC cells to chemotherapeutic agents. Mechanistically, we show that PHF20 interacts with and promotes the ubiquitin-mediated degradation of GAS7. This downregulation of GAS7 is associated with nuclear F-actin assembly, a process that has been implicated in DNA damage repair (DDR). Consequently, PHF20 loss stabilizes GAS7, enhances nuclear F-actin assembly, and is accompanied by increased DNA damage accumulation. These in vitro findings were corroborated in vivo, where PHF20 knockdown suppressed tumor growth and increased DNA damage. Together, PHF20 may contribute to the regulation of DDR and chemotherapeutic response, highlighting its potential as a therapeutic target in poorly differentiated cSCC. - Source: PubMed
Publication date: 2026/05/29
Li YunqianWen HeZheng HanZhen YunyueJia JingLi Zhengjun - Acute myocardial infarction (AMI) involves complex immune responses and cellular interaction mechanisms. Although the pathogenesis of AMI is now preliminarily understood, there is still a lack of biomarkers that can accurately and rapidly diagnose its disease characteristics. - Source: PubMed
Publication date: 2026/05/13
Liu ZhenfangSong JiaLi LinglingFan ZiyinXie GenyuanYang Li - Bladder cancer (BC) screening contributes to better patient outcomes. However, existing diagnostic methods for BC are not suitable for large-scale screening. Serum microRNAs (miRNAs) are expected to be simple, cost-effective, and non-invasive screening tools for BC. This study aims to identify whether relevant serum miRNAs as diagnostic markers for BC. - Source: PubMed
Publication date: 2026/01/26
Zhou HuimeiGe ZhenjianLin ShengjieWu YutongZhang PengwuLi XutaiZhao ZhengpingLai YongqingTao Lingzhi