CXorf26 (UPF0368 protein Cxorf26) Antibody (Clone#:5C6)
- Known as:
- CXorf26 (UPF0368 protein Cxorf26) Antibody (Clone#:5C6)
- Catalog number:
- amm11538c
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- CXorf26 (UPF0368 protein Cxorf26) Antibody (Clone#:5C6)
Related genes to: CXorf26 (UPF0368 protein Cxorf26) Antibody (Clone#:5C6)
- Gene:
- PBDC1 NIH gene
- Name:
- polysaccharide biosynthesis domain containing 1
- Previous symbol:
- CXorf26
- Synonyms:
- MGC874
- Chromosome:
- Xq13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-18
- Date modifiied:
- 2016-10-05
Related products to: CXorf26 (UPF0368 protein Cxorf26) Antibody (Clone#:5C6)
Related articles to: CXorf26 (UPF0368 protein Cxorf26) Antibody (Clone#:5C6)
- Transcription factors play an important role in regulating the expression of detoxification genes (e.g. P450s) that confer insecticide resistance. Our previous study identified a series of candidate transcription factors (CYP6B7-fenvalerate association proteins, CAPs) that may be related to fenvalerate-induced expression of CYP6B7 in a field HDTJ strain of H. armigera. Whether these CAPs can mediate the transcript of CYP6B7 induced by fenvalerate in a susceptible HDS strain of H. armigera remains unknown. Further study showed that the expression levels of multiple CAPs were significantly induced by fenvalerate in HDS strain. Knockdown of CAP19 [fatty acid synthase-like (FAS)], CAP22 [polysaccharide biosynthesis domain-containing protein 1 (PBDC1)], CAP24 [5-formyltetrahydrofolate cycloligase (5-FCL)], CAP30 [peptidoglycan recognition protein LB-like (PGRP)] and CAP33 [NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (NDUFA11)] resulted in significant inhibition of CYP6B7 and some other P450 genes expression; meanwhile, the sensitivity of HDS strain larvae to fenvalerate was significantly increased. In addition, PBDC1, PGRP and NDUFA11, either alone or in combination, could significantly enhance the activity of CYP6B7 promoter in HDS strain, as well as the expression level of CYP6B7 gene in Sf9 cells line. These results suggested that PBDC1, PGRP and NDUFA11 may be involved in the transcript regulation of key detoxifying genes in response to fenvalerate in HDS strain of H. armigera. - Source: PubMed
Publication date: 2024/04/20
Huang YunZheng JunyueWu PeizhuoZhang YuQiu Lihong - The phenotypic repercussion of ZDHHC15 haploinsufficiency is not well-known. This gene was initially suggested as a candidate for X-linked mental retardation, but such an association was later questioned. We studied a multiplex family with three members with autism spectrum disorder (ASD) by array CGH, karyotype, exome sequencing and X-chromosome inactivation patterns. Medical history interviews, cognitive and physical examinations, and sensory profiling were also assessed. The three family members with ASD (with normal cognitive abilities and an abnormal sensory profile) were the only carriers of a 1.7 Mb deletion in the long arm of chromosome X, involving: ZDHHC15, MAGEE2, PBDC1, MAGEE1, MIR384 and MIR325. The normal chromosome X was preferentially inactivated in female carriers, and the whole exome sequencing of an affected family member did not reveal any additional genetic variant that could explain the phenotype. Thus, in the present family, ASD segregates with a deletion on chromosome X that includes ZDHHC15. Considering our results together with gene data (regarding function, expression, conservation and animal/cellular models), ZDHHC15 is a candidate gene for ASD. Emerging evidence also suggests that this gene could be associated with other neurodevelopmental disorders, with incomplete penetrance and variable expressivity. - Source: PubMed
Publication date: 2022/12/23
Casellas-Vidal DolorsMademont-Soler IreneSánchez JoanaPlaja AlbertoCastells NeusCamós MariaNieto-Moragas JavierDel Mar García MariaRodriguez-Solera CeliaRivera HelenaBrunet JoanÁlvarez SaraPerapoch JosepQueralt XavierObón María - Many compounds have the potential to harm pancreatic beta-cells; organochlorine pollutants belong to those compounds. In this work, we aimed to find markers of acute toxicity of p,p'-DDT exposure among proteins expressed in NES2Y human pancreatic beta-cells employing 2-D electrophoresis. We exposed NES2Y cells to a high concentration (150 μM, LC96 after 72 hours) of p,p'-DDT for 24 and 30 hours and determined proteins with changed expression using 2-D electrophoresis. We have found 22 proteins that changed their expression. They included proteins involved in ER stress (GRP78, and endoplasmin), mitochondrial proteins (GRP75, ECHM, IDH3A, NDUS1, and NDUS3), proteins involved in the maintenance of the cell morphology (EFHD2, TCPA, NDRG1, and ezrin), and some other proteins (HNRPF, HNRH1, K2C8, vimentin, PBDC1, EF2, PCNA, biliverdin reductase, G3BP1, FRIL, and HSP27). The proteins we have identified may serve as indicators of p,p'-DDT toxicity in beta-cells in future studies, including long-term exposure to environmentally relevant concentrations. - Source: PubMed
Publication date: 2020/10/26
Pavlikova NelaSramek JanJelinek MichaelHalada PetrKovar Jan - Dendritic cells (DC) are central to the development of immune system responses. In a cohort of 54 patients affected by colorectal cancer, we prospectively investigated the number of peripheral blood (PB) DC type 1 (DC1) and type 2 (DC2) and correlated their counts and functionality to the stage of the disease and to vascular endothelial growth factor (VEGF) levels. - Source: PubMed
Publication date: 2005/07/07
Della Porta MatteoDanova MarcoRigolin Gian MatteoBrugnatelli SilviaRovati BiancaTronconi ChiaraFraulini ChiaraRusso Rossi AntonellaRiccardi AlbertoCastoldi Gianluigi