STAT6 Antibody (AMM00022)
- Known as:
- STAT6 Antibody (AMM00022)
- Catalog number:
- amm00022
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Aviva Systems Biology
- Gene target:
- STAT6 Antibody (AMM00022)
Related genes to: STAT6 Antibody (AMM00022)
- Gene:
- STAT6 NIH gene
- Name:
- signal transducer and activator of transcription 6
- Previous symbol:
- -
- Synonyms:
- D12S1644, IL-4-STAT
- Chromosome:
- 12q13
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-09
- Date modifiied:
- 2019-04-23
Related products to: STAT6 Antibody (AMM00022)
Related articles to: STAT6 Antibody (AMM00022)
- - Source: PubMed
Publication date: 2026/03/17
El Hussein SibaGeorge Giby VAdlowitz Diana GBenedict Lily BJelloul Fatima ZahraMedeiros L JeffreyBurack W RichardO'Malley Dennis P - Histone deacetylase 6 (HDAC6), a member of the class IIb HDAC family, plays a crucial role in epigenetic regulation and cytoskeletal dynamics, while participating in host anti-infective immune responses. However, its precise functions and mechanisms during () infection remain incompletely defined. Our study demonstrated that respiratory infection upregulates HDAC6 expression at the infection site and in immune organs. Comparative analysis of wild-type (WT) and HDAC6-deficient (HDAC6) mice in this infection model revealed that HDAC6 deficiency exacerbates disease progression, including significant weight loss, severe pulmonary inflammation, and impaired clearance. Relative to WT mice, HDAC6 mice exhibited elevated Signal Transducer and Activator of Transcription 6 () and GATA Binding Protein 3 () mRNA expression, enhanced pathological Th2 responses with increased IL-4 secretion, and no significant differences in protective Th1 or Th17 responses following infection. Concurrently, these mice displayed enhanced M2 macrophage polarization, as evidenced by upregulated CD206 and Arg-1 expression, whereas M1 marker expression remained unchanged. The vitro studies confirmed that HDAC6 bone marrow-derived macrophages (BMDMs) promote M2 polarization, characterized by increased Arg-1, IL-10, and TGF-β production, and further co-culture experiments showed that -stimulated HDAC6 BMDMs drive Th2 differentiation. These findings elucidate the critical role of HDAC6 in regulating Th2-M2 immune responses during respiratory infection and suggest targeted modulation of HDAC6 as a novel therapeutic strategy for chlamydial respiratory infection. - Source: PubMed
Publication date: 2026/03/26
Yu JinxiYang ShuainiZha XiaoyuTuo YuqingSun RuoyuanZhang HongTan LuBai Hong - Corneal sensory nerve plays a critical role in pain sensation and corneal wound healing. However, the molecular mechanisms that regulate corneal nerve repair, especially couple immune regulation to corneal nerve repair remain poorly understood. Here, Mitsugumin 53 (MG53), a E3 ubiquitin ligase, is identified as a pivotal regulator of macrophage-mediated corneal nerve regeneration. MG53 is present in tear film, aqueous humor, and corneal epithelial cells, suggesting its role in corneal homeostasis. In an alkali burn injury model, genetic ablation of MG53 impairs nerve regrowth, whereas genetic overexpression or delivery of MG53 modified RNA markedly enhanced corneal nerve regeneration. Mechanistically, MG53 interacts with major vault protein (MVP) and promotes its K63-linked ubiquitination at lysine 747, facilitating STAT6 nuclear translocation and transcriptionally activating M2 (reparative) macrophage genes. MG53 overexpression biases macrophage polarization toward a reparative phenotype characterized by elevated Arg1, Fizz1, Ym1/2, and IRF4 expression, thereby enhancing clearance of degenerating nerve fragments and promoting nerve regeneration. Using a genome-wide Membrane Proteome Array (MPA) screen, macrophage-expressed gene 1 (MPEG1) is identified as a putative receptor mediating MG53 internalization in macrophages. These findings establish a mechanistic framework in which circulating MG53 engages the MPEG1-MVP-STAT6 axis to coordinate macrophage polarization and neuroimmune repair. - Source: PubMed
Publication date: 2026/04/10
Chen PengZhang ZhentaoSakai LilianXu YanpingZhang LuxiYe HanSollenberger WilliamIkeda TakahideYan ZhiyuSathish KeerthikaAlizai UsmanWen HaitaoPawlik Timothy MChandler Heather LZhu Hua - To explore the clinicopathological features, immunophenotype, molecular characteristics, and prognosis of primary malignant solitary fibrous tumor (MSFT) of the kidney. The clinicopathological data of four renal MSFT cases diagnosed at the Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China and one case at the Ningbo Clinical Pathology Diagnostic Center, Ningbo, China between 2015 and 2025 were collected. The clinical features, histomorphology, and immunohistochemical characteristics were analyzed. Fluorescence in situ hybridization (FISH) and RNA-based next-generation sequencing were performed. Follow-up and review of relevant literature were conducted. Among the five patients, three were male and two were female, aged 70(61,71) years. The tumors were all found during routine physical examinations. Four cases (cases 1, 3, 4, and 5) occurred in the left kidney, and one case (case 2) first occurred in the left kidney and recurred in the right kidney 5 years later. Four cases had a single lesion with a maximum diameter of 6.0-19.0 cm, and one case (case 5) had 2 lesions with maximum diameters of 2.0 cm and 4.0 cm, respectively. Histologically, three cases (cases 1, 2, and 5) were de novo MSFT, one case (case 5) was morphologically similar to synovial sarcoma with spindle cells arranged densely in bundles, one case (case 1) had sheets of epithelioid tumor cells, and one case (case 2) had alternating myxoid and spindle cell areas, with sparse tumor cells in the myxoid areas and dense tumor cells in the spindle cell areas. Two cases (cases 3 and 4) were classic solitary fibrous tumor (SFT) with dedifferentiation, and the dedifferentiated components were high-grade undifferentiated sarcoma. In the typical SFT areas, tumor cells were alternately dense and sparse, with collagenized areas and rare mitotic figures, while branching or hemangiopericytoma-like structures were also present. In the dedifferentiated areas, tumor cells were spindle-shaped or epithelioid with conspicuous nucleoli. Necrosis was seen in all three de novo MSFT cases (cases 1, 2, and 5) and one dedifferentiated case (case 4). The mitotic figures in three de novo SFT cases and two dedifferentiated areas were 4 to 10 per 10 HPF. No heterologous differentiation was found in any of the five cases. According to the Demicco risk classification, four cases were of moderate risk, and one case (case 4) was of high risk. Four cases showed diffuse expression of STAT6, while one case (case 3) showed partial expression. CD34 was diffusely positive in 3 cases, partially positive in one case (case 4) and negative in one case (case 1). Only one of the 5 cases expressed CKpan which was focally positive. PAX8, desmin, BCOR, S-100 protein, Melan A and HMB45 were all negative. H3k27Me3 expression was retained. FISH showed no SYT (SS18, 18q11) rearrangements in two cases (cases 4 and 5), and no MDM2 amplification in one case (case 5). RNA sequencing in four cases detected NAB2::STAT6 gene fusion, all of which were NAB2ex6::STAT6ex16 fusion subtypes. Follow-up data were available for four cases, with the follow-up period of 11-30 months. Among the 4 cases, one case had liver metastasis 3 months after surgery, and one case of left renal MSFT (moderate risk) had right renal recurrence 5 years after surgery. The other two had no recurrence or metastasis. Renal MSFT with moderate to high-risk is rare, shows a wide morphological spectrum and needs to be differentiated from various tumors. Extensive sampling, careful morphological observation, immunohistochemical staining and molecular detection of NAB2::STAT6 fusion are helpful for the diagnosis. It appears to have aggressive biological behaviors. - Source: PubMed
Zhang H ZXu J KYu YYang X Q - Glomangiopericytoma (GPC) is a rare, low-grade mesenchymal neoplasm that most commonly arises in the nasal cavity and paranasal sinuses. Its rarity, together with overlapping histopathological features shared with other spindle-cell tumors, makes diagnosis challenging, and available data regarding its clinical behavior and optimal management remain limited. This study aimed to present a retrospective case series of GPC from a tertiary referral center, with particular emphasis on clinical presentation, diagnostic evaluation, histopathological characteristics, surgical management, and outcomes. - Source: PubMed
Publication date: 2026/03/31
Alanzi Abdulaziz RajehLee Young HaYu Myeong Sang