Monoclonal Mouse TGFB1 Antibody
- Known as:
- Monoclonal Mouse TGFB1 Antibody
- Catalog number:
- abx000042
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- Monoclonal Mouse TGFB1 Antibody
Ask about this productRelated genes to: Monoclonal Mouse TGFB1 Antibody
- Gene:
- TGFB1 NIH gene
- Name:
- transforming growth factor beta 1
- Previous symbol:
- TGFB, DPD1
- Synonyms:
- CED, TGFbeta
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-16
- Gene:
- TSC22D1 NIH gene
- Name:
- TSC22 domain family member 1
- Previous symbol:
- TGFB1I4
- Synonyms:
- TSC22, MGC17597
- Chromosome:
- 13q14.11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-16
- Date modifiied:
- 2016-10-05
Related products to: Monoclonal Mouse TGFB1 Antibody
Related articles to: Monoclonal Mouse TGFB1 Antibody
- TSC-22 gene was composed of three exons and its length was approximately 5.5 kb including 2.9 kb promoter region. The transcription starting site was located at 7 and 29 bp downstream from TATA box. Promoter analysis revealed that 2146 bp of TSC-22 promoter was activated by several differentiation inducing drugs. Although originally TSC-22 was isolated as a TGF-beta-inducible gene, TSC-22 promoter was not activated by the enhanced TGF-beta signaling. We found 3 copies of the Shaw-Kamens sequence (AUUUA) in the human TSC-22 mRNA 3'-UTR and identified three proteins (40, 20, and 15 kDa) which bound to this. Only the 40 kDa protein-RNA complex was decreased by treatment with TGF-beta 1. Moreover, the TSC-22 mRNA 3'-UTR destabilized the heterologous luciferase mRNA, but the destabilization was recovered with TGF-beta 1. These observations suggest that up-regulation of TSC-22 mRNA by TGF-beta 1 is achieved by mRNA stabilization, but not by transcriptional activation. - Source: PubMed
Uchida DaisukeOmotehara FumieNakashiro Koh-ichiTateishi YoshihisaHino SatoshiBegum Nasima-MilaFujimori TakahiroKawamata Hitoshi