Polyclonal Rabbit PRKCI Antibody
- Known as:
- Polyclonal Rabbit PRKCI Antibody
- Catalog number:
- abx000784
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- Polyclonal Rabbit PRKCI Antibody
Related genes to: Polyclonal Rabbit PRKCI Antibody
- Gene:
- PRKCI NIH gene
- Name:
- protein kinase C iota
- Previous symbol:
- DXS1179E
- Synonyms:
- PKCI
- Chromosome:
- 3q26.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-06
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal Rabbit PRKCI Antibody
Related articles to: Polyclonal Rabbit PRKCI Antibody
- Mother-to-child disease transmission begins in utero, with the placenta playing a critical role in pregnancy and offspring health. Uterine leiomyomata (fibroids, UFs) and endometriosis (ENDO) are common gynecologic diseases that have substantial overlaps in symptomology and risk factors, however drivers of disease risk remain unclear. The objective of this study was to investigate shared placental genetic associations across ENDO and UFs. - Source: PubMed
Publication date: 2026/04/01
Akerele Alexis THampton GabrielleKim JeewooJaworski JamesLewis Toni JKhan AtlasRasmussen-Torvik Laura JLuo YuanJasper Elizabeth AHellwege Jacklyn NEdwards Todd LVelez Edwards Digna R - Head and neck cancer (HNC) represents the seventh most common cancer diagnosis globally, yet current treatments, including surgery, radiation, and immunotherapy, have shown limited improvement in outcomes. Drug repurposing offers a cost-effective strategy to identify new therapeutic options by leveraging existing medications with known safety profiles. Within this study, we developed the pipeline (enomic lteration-based epurposing for rugs), designed to uncover repurposing candidates for HNC using genomic and network-based approaches. : GARD integrates multi-omics data from The Cancer Genome Atlas (TCGA), including copy number variation (CNV) and somatic mutations (SOM). The cohort was stratified by human papillomavirus (HPV) status. Risk-associated genes were identified and then expanded via high-confidence protein-protein interaction (PPI) networks. Top candidate genes were filtered through comprehensive analysis of publicly available literature data in PubMed using LLMs to validate the relationship between the identified genes and HNC. The top risk genes and their network-expanded neighbors were mapped against DrugBank, and through statistical significance testing and literature validation, established significant drug-gene associations. : Significant genes associated with HNC, inferred by genomics alteration, were identified across HPV-positive and HPV-negative subgroups, such as PIK3CA, SOX2, TP53, EIF4G1, TLR7, CLDN1, PRKCI, and EPHA2. Further expansion through the PPI network identified other targetable genes such as EGFR, ERBB2, and the FGFRs. Literature-based validation efforts ensured confidence in the gene-disease association. Drug-gene mapping revealed candidates spanning those already in clinical trials for HNC (e.g., Afatinib, Cabozantinib, Dasatinib, Brigatinib, Lenvatinib, Capivasertib, and Erdafitinib) and emerging or repurposing candidates (Amuvatinib, XL765 (Voxtalisib), Golotimod, Artenimol, Quercetin, and Acetylsalicylic Acid), offering opportunities for precision repurposing. : The GARD pipeline demonstrates a genomics-driven, network-informed framework for systematic drug repurposing in HNC. HPV stratification enhances precision, literature-based validation strengthens confidence, and integrated drug mapping enables refinement of existing therapies and discovery of novel candidates for personalized treatment strategies. : The full implementation of the GARD pipeline, including preprocessing scripts, statistical analysis modules, and visualization tools, is publicly available on GitHub. - Source: PubMed
Publication date: 2026/02/26
Tanikella PradhamNenad WilliamCourtine ChristopheDai YifanDeng QingyingZou BaimingOsazuwa-Peters NosayabaSchrank Travis PWu Di - The genus , classified within the family Sciuridae and the subfamily Callosciurinae, is distributed across East and Southeast Asia. The taxonomic classification of has historically been contentious, with species diversity often underestimated due to reliance on pelage color variations for species descriptions, which are thought to reflect seasonal changes. To clarify the internal phylogenetic relationships and taxonomic status of the species, we conducted morphological analyses and constructed multi-locus phylogenetic trees using a large DNA dataset that encompassed one mitochondrial locus (Cyt-b) and three nuclear loci (IRBP, PRKCI, RAG1), as well as 20 complete mitochondrial genomes. We identified seven well-supported monophyletic clades of based nuclear data evidence. The K2P genetic distances among the seven lineages of varied from 0.095 to 0.204. Consequently, we elevated one subspecies . to full species status, having diverged from its common ancestor approximately 6.01 million years ago. Ultimately, we recognized a total of seven valid species within the genus , which include . , . , . , . , . , . , and . . Divergence time estimation suggested that began to diversify approximately 13.3 million years ago (Mya). Our findings provide insights into the evolutionary relationships and previously overlooked species diversity within the genus . - Source: PubMed
Publication date: 2026/02/11
Zou YanHui LangeHuang WenhaoJi RongTang XinyuWang XumingChen ShundeLi SongLiu ShaoyingTang Keyi - Head and neck cancer (HNC) represents the seventh most common cancer diagnosis globally, yet current treatments, including surgery, radiation, and immunotherapy, have shown limited improvement in outcomes. Drug repurposing offers a cost-effective strategy to identify new therapeutic options by leveraging existing medications with known safety profiles. Within this study we developed the pipeline (enomic lteration-based epurposing for rugs), designed to uncover repurposing candidates for HNC using genomic and network-based approaches. - Source: PubMed
Publication date: 2026/01/16
Tanikella PradhamNenad WillCourtine ChristopheDai YifanDeng QingyingZou BaimingOsazuwa-Peters NosayabaSchrank TravisWu Di - [This corrects the article DOI: 10.3389/fonc.2022.887139.]. - Source: PubMed
Publication date: 2026/01/13
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