EFNB2 (phospho-Tyr330) Antibody
- Known as:
- EFNB2 (phosphorilated-Tyr330) Antibody
- Catalog number:
- abx000387
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- EFNB2 (phospho-Tyr330) Antibody
Related genes to: EFNB2 (phospho-Tyr330) Antibody
- Gene:
- EFNB2 NIH gene
- Name:
- ephrin B2
- Previous symbol:
- EPLG5
- Synonyms:
- LERK5, Htk-L, HTKL, MGC126226, MGC126227, MGC126228
- Chromosome:
- 13q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-01-17
- Date modifiied:
- 2016-10-05
Related products to: EFNB2 (phospho-Tyr330) Antibody
Related articles to: EFNB2 (phospho-Tyr330) Antibody
- Both rare and common variants in the SRY-Box Transcription Factor 17 ( ) locus are associated with pulmonary arterial hypertension (PAH). SOX17 dysregulation leads to pulmonary artery endothelial cell (PAEC) dysfunction and the obstructive remodelling that characterises PAH. - Source: PubMed
Publication date: 2026/05/18
Vasilaki EleniAkosman BediaSong ShanshanWalters RachelSharma YaminiPereira MandyKeles MerveMykytyuk Nadiya VMaude HannahSingh NavneetField GeorgeVentetuolo Corey EHoward Luke SAman JurjanWilkins Martin RKlinger James RZhao LanCebola InêsLiang Olin DRhodes Christopher J - Synaptogenesis-related neuron-glioma interactions are increasingly recognized in glioma, yet it remains unclear whether routine H&E morphology can capture these programs and improve prognostic stratification. We integrated H&E whole-slide images, transcriptomes, and clinical data from 434 TCGA gliomas. Deep learning and quantitative pathology yielded an integrated histomorphologic feature set of 2678 features. Synaptogenesis-related activity was quantified using ssGSEA for ninety-eight synaptogenesis-related genes. In the training cohort, Spearman analysis identified 149 correlated histomorphologic features, which were refined to thirty-five by elastic net regularization. Seventeen prognostic candidates were entered into the MIME1 framework, and the most parsimonious model, Enet[0.1], retained fourteen non-zero-coefficient features to define the synaptogenesis-associated histomorphologic signature and construct the pathology-derived risk score (PRS). Multi-omic analyses, Human Protein Atlas validation, and single-nucleus RNA-seq were used to investigate the hub gene and its cellular context. PRS robustly stratified survival in both training and validation cohorts and remained an independent prognostic factor after adjustment for age and 2021 WHO CNS grade. High-risk tumors showed increased stromal and immune scores and enrichment of immune, adhesion, and phagosome-related pathways. emerged as the hub gene and was enriched in glioblastoma, and -positive malignant cells displayed prominent communication with neurons, including EFNB2-EPHB1 signaling. Exploratory re-analysis of the myeloid compartment further showed that glioblastoma was enriched for suppressive TAM-like states relative to astrocytoma grade 2, supporting a shift toward a more tumor-associated and potentially immunosuppressive microenvironment. Routine H&E histomorphology can capture synaptogenesis-related molecular programs in glioma. The resulting PRS provides clinically relevant prognostic stratification, while -positive malignant cells may represent a candidate hub for neuron-tumor communication within a remodeled tumor ecosystem. - Source: PubMed
Publication date: 2026/05/12
Wu XiaolongLiu DongGeng HaomingZhang BinghanDiao HuantongZhou YiqiangSong GangCheng YeLiang Jiantao - Mild hypothermia (MH) has been reported to ameliorate cerebral damage and neurofunctional deficits in ischemic stroke, but its molecular mechanisms remain unclear. This study focuses on exploring the neuroprotective regulatory mechanisms mediated by MH in ischemic stroke. - Source: PubMed
Publication date: 2026/05/20
Feng GanghuaHu YabinLi QiuliWu JibaoLei YuanbiaoWang HaoYao Xiaoxi - Pancreatic cancer is a highly aggressive malignancy with a 5-year relative survival rate of only 13%. Current treatment options have limited efficacy, and mRNA vaccines offer a new direction for its treatment. However, how to accurately identify antigen targets that possess tumor specificity, functional relevance, and immunogenicity remains the key bottleneck restricting the clinical translation of mRNA vaccines for pancreatic cancer. Recent clinical studies have advanced KRAS mutant vaccines and personalized neoantigen mRNA vaccines, yet most rely on single antigens or highly individualized designs, limiting scalability and broader clinical applicability. In this systematic review, we integrated evidence from public databases and experimental studies to identify and evaluate 16 potential pancreatic cancer mRNA vaccine antigens (ADAM9, WNT7A, TMOD3, MET, EFNB2, TPX2, AGPS, OSBPL9, KDM5A, NRAS, SCP-1, GAGE, RAB5A, ANO6, CHMP2B, and PAK2). All candidates were initially selected based on aberrant tumor expression and further prioritized using stratification strategies incorporating antigen-presenting cell infiltration, immune-related cell death pathways such as ferroptosis and pyroptosis, and functional relevance to tumor progression. ADAM9 and PAK2 showed high expression in pancreatic cancer and strong associations with tumor proliferation, invasion, and immune regulation. SCP-1 and GAGE, as cancer-testis antigens, exhibited high tumor specificity and immunogenic potential. In addition, KDM5A and ANO6 may enhance antitumor efficacy through modulation of ferroptosis or pyroptosis. Nevertheless, several candidates remain constrained by normal tissue expression or limited mechanistic evidence. This review provides a stratified framework for antigen prioritization and highlights key challenges in pancreatic cancer mRNA vaccine development, offering guidance for future multi-antigen vaccine design and translational immunotherapy. - Source: PubMed
Publication date: 2026/04/28
Xue YuzheYu JiaqiZhou HongkunChen WeiChen QiHu LingyuLuo RunzhouChen YingjingWang XiaoguangHe Xuesong - Behçet disease (BD) is an inflammatory disorder with significant ocular involvement. Angiopoietins regulate vascular stability, while EphrinB2/EphB4 interactions are essential for retinal neovascularization and endothelial behavior. Endocan, a marker of endothelial activation, contributes to inflammatory processes by mediating leukocyte migration. This cross-sectional study investigates the role of angiopoietins, EphrinB2/EphB4 signaling, and endocan in the development of active uveitis in BD patients. We recruited 29 BD patients with active eye involvement (group 1), 31 BD patients without eye involvement (group 2), and 30 healthy controls (group 3). Serum tyrosine protein kinase receptor (Tie-2), angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), EphrinB2, EphB4, and endocan levels were determined by the enzyme-linked immunosorbent assay method. A statistically significant difference was found between the Ang-1, Ang-2, Tie-2, EphrinB2, EphB4, and endocan levels of the 3 different groups in the study (P < .05). Between the patients with panuveitis and patients with only posterior or anterior uveitis, serum Ang-1 (P < .001), Tie-2 (P < .001), EphrinB2 (P < .001), EphB4 (P = .001), and endocan (P = .002) levels had statistically significant differences. The highest and significant correlation was found between EphrinB2 and EphB4 (r = 0.931, P < .001). This was followed by a high level of significant correlation between Ang-1 and Ang-2 (r = -0.845, P < .001). In the group with active uveitis, EphB4 (r = -0.774), Ang-2 (r = -0.763), and Tie-2 (r = -0.701) were negatively and highly significantly correlated with best corrected visual acuity (P < .001). Ang-1, Ang-2, Tie-2, EphrinB2, EphB4, and endocan regulate vascular stability, retinal neovascularization, and inflammation, potentially contributing to BD-associated uveitis. These findings could have important implications for the diagnosis and management of ocular involvement of BD. - Source: PubMed
Gökçek Barutcigil BetülÇinici EmineLaloglu Esra