MAPK14 (phospho-Tyr182) Antibody
- Known as:
- MAPK14 (phosphorilated-Tyr182) Antibody
- Catalog number:
- abx000291
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- MAPK14 (phospho-Tyr182) Antibody
Related genes to: MAPK14 (phospho-Tyr182) Antibody
- Gene:
- MAPK14 NIH gene
- Name:
- mitogen-activated protein kinase 14
- Previous symbol:
- CSPB1, CSBP1, CSBP2
- Synonyms:
- PRKM14, p38, Mxi2, PRKM15
- Chromosome:
- 6p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-01-24
- Date modifiied:
- 2016-10-05
Related products to: MAPK14 (phospho-Tyr182) Antibody
Related articles to: MAPK14 (phospho-Tyr182) Antibody
- Zinc (Zn) is an essential trace element that plays important roles in growth, digestion, antioxidant defense, immunity, and inflammation regulation in fish. This study investigated the effects of graded dietary Zn levels on growth performance, serum biochemistry, digestive enzyme activity, zinc transporter expression, antioxidant capacity, immune responses, and inflammatory regulation in juvenile black carp (). Six isonitrogenous and isoenergetic diets were formulated to contain 27.95, 34.38, 44.90, 66.52, 116.14, and 199.56 mg/kg Zn by supplementing ZnSO·7HO. Juvenile fish with an initial weight of 2.88 ± 0.12 g were fed the experimental diets for 60 days in triplicate tanks. Growth performance increased with dietary Zn and then plateaued at 44.90-199.56 mg/kg; broken-line regression estimated the optimal dietary Zn requirement at 44.6 mg/kg. Adequate Zn supplementation also reduced whole-body lipid content, increased digestive enzyme activities, improved serum HDL-C and ALP levels, and decreased AST and ALT activities. In addition, adequate dietary Zn (44.90 mg/kg) significantly modulated the expression of zinc transporter genes in the liver and intestine. Adequate dietary Zn supplementation enhanced antioxidant capacity by activating the Nrf2/Keap1 signaling pathway, improved intestinal immunity, and strengthened barrier function by increasing the expression of tight junction proteins and mucins. Moreover, adequate dietary Zn could alleviate inflammatory responses by upregulating anti-inflammatory factors and downregulating pro-inflammatory cytokines via the signaling pathway. These findings suggest that dietary zinc at 44.60 mg/kg is sufficient to promote growth, antioxidant status, immune function, and intestinal health in juvenile black carp. - Source: PubMed
Publication date: 2026/06/16
Yu JiaxingZhang PenghuiZhang XunshangZhu XiaotongXie YuanyuanZhang HaoShao XianpingXie MingxuLiu YanYang XiaWu Chenglong - To identify the active components of Yiguanjian Decoction (YGJ) and elucidate their molecular actions against thyroid cancer. - Source: PubMed
Publication date: 2026/06/17
Liang Rui-MinSong Fa-HuanDeng Xin-YueXu Shu-TingWang Ling-HuiGuo Ya-WenZhu Lei - Colorectal cancer (CRC) is a significant global health challenge, necessitating a comprehensive molecular understanding for personalized treatments. Molecular profiling has elucidated key biomarkers that are essential for prognosis, treatment responsiveness, and targeted therapeutic interventions. - Source: PubMed
Publication date: 2026/05/10
Alibakhshi AbbasGharibi ShimaShojaeian AliAsgari AtefehAmini RaziehRahimmalek MehdiAhangarzadeh ShahrzadSzumny Antoni - Food allergies (FAs) significantly impact quality of life. Allergen-specific immunotherapy (AIT) shows promise but faces limitations such as prolonged treatment duration, systemic side effects, and poor compliance, especially in pediatric and elderly populations. Complementary and alternative medicine (CAM) may enhance AIT efficacy and safety, yet the mechanisms underlying immune tolerance remain poorly understood. This study employed an integrated approach combining network pharmacology, molecular simulation, and metabolomics to investigate anti-allergic medicinal plants in FA. Active compounds from 13 medicinal plants were analyzed to predict key targets and pathways. Molecular docking and dynamics simulations assessed compound-target binding affinities, while metabolomics evaluated tissue distribution and bioavailability in lymphoid tissues. The results identified transforming growth factor-beta 1 (TGFB1) as a key target associated with the FoxO signaling pathway and Th17 cell differentiation, both of which are critical for promoting allergic tolerance. MAPK1 and MAPK14 emerged as additional targets, providing insights into the mechanisms of allergy development. Molecular simulations demonstrated strong binding affinities, with quercetin (-9.1 kcal/mol) and genistein (-8.1 kcal/mol) binding to TGFB1, and isoprocurcumenol (-7.1 kcal/mol) and dicinnamoylmethane (-10.1 kcal/mol) binding to MAPK1 and MAPK14, respectively. Metabolomic analysis further showed high genistein accumulation in lymph nodes. In summary, these findings suggest that CAM-AIT integration could significantly improve FA therapeutic outcomes by promoting immune tolerance and modulating inflammatory pathways. - Source: PubMed
Publication date: 2026/05/09
Marhaeny Honey DzikriSusilawati DelisHayeeawaema FittreeAliyah Alma NurilPratama Yusuf AlifNurfinti Wa OdeWardani Hijrawati AyuMuslikh Faisal AkhmalTanujaya Angeline FeliscaNurhan Ahmad DzulfikriWidiandani TriPurwanto Bambang TriMiatmoko AndangKhotib Junaidi - Neonatal sepsis is a life-threatening condition with high mortality. Ferroptosis and cuproptosis, oxidative stress-related cell death pathways, are implicated in sepsis pathogenesis, but their role in neonatal sepsis remains unclear. This study aimed to identify and validate diagnostic biomarkers for neonatal sepsis associated with ferroptosis and cuproptosis pathways using integrated bioinformatics and machine learning approaches, and to explore potential therapeutic targets. - Source: PubMed
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