STMN1 (phospho-Ser16) Antibody
- Known as:
- STMN1 (phosphorilated-Ser16) Antibody
- Catalog number:
- abx000281
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- STMN1 (phospho-Ser16) Antibody
Related genes to: STMN1 (phospho-Ser16) Antibody
- Gene:
- STMN1 NIH gene
- Name:
- stathmin 1
- Previous symbol:
- LAP18, C1orf215
- Synonyms:
- SMN, OP18, PR22, PP19, PP17, Lag, FLJ32206
- Chromosome:
- 1p36.11
- Locus Type:
- gene with protein product
- Date approved:
- 1990-12-17
- Date modifiied:
- 2014-11-19
Related products to: STMN1 (phospho-Ser16) Antibody
Related articles to: STMN1 (phospho-Ser16) Antibody
- Chronic stress significantly contributes to anxiodepression, with marked sex differences in hippocampal dysfunction. This study investigated the interplay between sex and stress phenotype in shaping hippocampal phosphorylation landscapes in a chronic restraint stress model of anxiodepression. Hippocampal phosphoproteomes of female and male mice, classified as anxiodepression-susceptible (AD-Sus) and insusceptible (Insus), were analyzed using 4D label-free quantitative proteomics. Distinct phosphorylation profiles associated with sex and phenotype were identified, with the corresponding phosphoproteins primarily linked to the MAPK signaling pathway. Females exhibited significant enrichment in the thyroid hormone signaling pathway and long-term potentiation. In contrast, males showed notable enrichment in the serotonergic synapse pathway, which suggests a sex-specific difference in serotonin-mediated emotional responses. GABAergic synapses were more prevalent in the Insus group than in the AD-Sus group, while the cGMP-PKG signaling pathway was enriched in both female and male AD-Sus groups. MAPK1 was identified as the kinase with the highest number of phosphorylated substrates across all groups, indicating its potential central role. Key phosphorylation targets included Stmn1 (S38) and Pdha1 (S232) in the female AD-Sus and Insus groups, and Stmn1 (S38) and Mapt (T523) in the female and male Insus groups. The Insus group exhibited additional kinases linked to numerous substrates, indicating a more complex kinase regulation mechanism compared to the AD-Sus group, where MAPK1 played a more pronounced role. Our findings demonstrate distinct sex- and phenotype-specific phosphorylation patterns, highlighting novel molecular mechanisms underlying stress-induced anxiodepression and resilience. - Source: PubMed
Publication date: 2026/06/20
Liu YanchenWang TingtingZhao WenjingYang ChenZhao YuxiLu FengmeiCai XiaoWang LiliLi ShuimingZhou JianHe Zongling - Type 1 diabetes (T1D) exhibits age-related heterogeneity in clinical progression and immune pathology, yet the underlying molecular mechanisms remain poorly understood. Here, we integrate microbiome, metabolome, lipidome, and transcriptome profiling from 108 newly diagnosed pediatric patients with T1D, along with 56 healthy controls, to investigate age-related endotypes. Patients were stratified into early-onset (E-T1D, <7 years), intermediate-onset (I-T1D, 7-12 years), and late-onset (L-T1D, ≥13 years) groups. Multi-omics analyses revealed distinct molecular signatures among T1D subgroups. The most enriched microbial signatures were the genus Acetatifactor in E-T1D, the phylum Firmicutes A in I-T1D, and the family Bacteroidaceae in L-T1D (Linear Discriminant Analysis scores = 3.49, 5.56, and 5.78, respectively). For metabolites, pipecolic acid increased most in E-T1D, testosterone in I-T1D, while N-acetylhomocitrulline was most enriched in L-T1D. Lipidomic profiling revealed subgroup-specific alterations, with increased levels of LPA(16:1) in E-T1D, TG(16:0/18:2/18:3) in I-T1D, and TG(18:0/18:1/18:1) in L-T1D. The proportion of peripheral B cells to total lymphocytes was the highest in E-T1D (median = 11.64%) and associated with upregulated immune-related pathways, lowest in L-T1D (median = 5.99%) and linked to metabolic processes, while I-T1D (median = 8.47%) exhibited intermediate features of both groups. Integration of multi-omics interaction networks and experimental validation revealed that the microbial species Dialister invisus may promote peripheral B cell proliferation via docosapentaenoic acid, potentially contributing to early-onset T1D. Together, these findings provide a molecular framework for understanding age-related T1D endotypes and suggest potential targets for precision intervention. Workflow and key findings of the study.A multi-omics integration strategy was applied to newly diagnosed pediatric type 1 diabetes (T1D) patients stratified by age at diagnosis: early-onset (E-T1D), intermediate-onset (I-T1D), and late-onset (L-T1D), to delineate age-related T1D endotypes. Comprehensive profiling included gut microbiome, serum metabolome, lipidome, and peripheral immune transcriptome analyses. An integrated multi-omics interaction network revealed 665 direct microbiota-gene connections and 2,608 microbiota-metabolite/lipid-gene triadic interactions, highlighting a D. invisus-docosapentaenoic acid (DPA)-STMN1 axis mediating B-cell activation in early-onset T1D. - Source: PubMed
Publication date: 2026/06/15
Pan LanxinTan HuilingYue TongDing YuGu ZhaoheWang XulinWang JingWei TianZhang XiaoyaShi YuChang ShiruGuo ChuangZheng XueyingWeng Jianping - Microtubule dynamic instability underpins cellular architecture, division, and intracellular trafficking, yet how selective proteolytic pathways tune core microtubule regulators remains incompletely understood. Here, we identify SEC14L2 (SEC14-like lipid binding 2), a multidomain lipid transfer protein, as a determinant of microtubule organization and cellular architecture by limiting the accumulation of the microtubule-destabilizing factor Stathmin 1 (STMN1). We further show that STMN1 is a substrate of chaperone-mediated autophagy (CMA) and that SEC14L2 is required for efficient CMA-dependent STMN1 turnover. SEC14L2 loss is associated with reduced CMA activity, STMN1 stabilization, collapse of the microtubule network, and perinuclear organelle clustering. In breast cancer cell models, perturbation of this SEC14L2-CMA-STMN1 axis alters responses to microtubule-targeting agents. - Source: PubMed
Publication date: 2026/06/10
Li GuangyuanXu HanfangGong BoJia Shunji - The association between lactylation and tumor radiotherapy has become a widely studied hotspot. However, the prognostic value of lactylation-related genes (LRGs) linked to radiotherapy‑associated transcriptional changes in cervical cancer remains unclear. - Source: PubMed
Publication date: 2026/06/03
Tang YiNing LiyuYang XinruLi NaLi YanyuZhou YunHui Hui - Microvascular invasion (MVI) is closely related to the recurrence and metastasis of hepatocellular carcinoma (HCC), but the underlying cellular mechanism remains largely elusive. This study aims to elucidate the regional cellular discrepancy between MVI-positive (MVI+) and MVI-negative (MVI-) HCC by integrating Spatial transcriptomics (ST) and spatial metabolomics (SM). - Source: PubMed
Publication date: 2026/05/15
Luo Zhi-HuiWang NaZhao JingweiLong FeiWu SiZhong WeiChen Wei-MingWang BichengWang KunYuan YufengZhou JingjiaoYuan ChunhuiWang Fubing