PRKCQ (phospho-Ser695) Antibody
- Known as:
- PRKCQ (phosphorilated-Ser695) Antibody
- Catalog number:
- abx000244
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- PRKCQ (phospho-Ser695) Antibody
Related genes to: PRKCQ (phospho-Ser695) Antibody
- Gene:
- PRKCQ NIH gene
- Name:
- protein kinase C theta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-14
- Date modifiied:
- 2016-10-05
Related products to: PRKCQ (phospho-Ser695) Antibody
Related articles to: PRKCQ (phospho-Ser695) Antibody
- : Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, includes two main subtypes, embryonal (eRMS) and alveolar (aRMS), each with distinct molecular and clinical characteristics. Although cellular processes underlying RMS and differences between PAX3-FOXO1 fusion-positive and fusion-negative tumors are well known, the contribution of long noncoding RNAs (lncRNAs) remains poorly understood. : Here, we reannotated publicly available microarray datasets to comprehensively profile lncRNA expression and reconstruct lncRNA-miRNA-mRNA regulatory networks in RMS. : We identified several lncRNAs with subtype-specific differential expression, including as a potential sponge for miR-206, for miR-885-5p, and for miR-515-5p in eRMS. Database-supported interaction analyses identified putative regulatory relationships between these lncRNAs and cancer-related miRNAs and mRNAs. Validation using the St. Jude Cloud PeCan platform confirmed distinct lncRNA expression signatures across RMS subtypes and other pediatric solid tumors, supporting subtype-specific regulation. : Our findings provide an updated characterization of the lncRNA landscape in RMS and identify candidate lncRNA-miRNA-mRNA regulatory networks that may contribute to disease biology. The proposed regulatory interactions are hypothesis-generating and require experimental validation. Overall, our findings provide a resource for future functional studies and support the investigation of lncRNAs as potential biomarkers and therapeutic targets in RMS. - Source: PubMed
Publication date: 2026/07/22
Zablocki da Luz JessicaBarbosa Leonardo ViníciusRodrigues Dos Santos Thiagode Almeida Roque AlicianeConfortin CamilaSoares Fulan Amanda Beatrizde Noronha LúciaMorselli Gysi DeisyMachado-Souza Cleber - In T cells, Dual Oxidase 2 (DUOX2) is responsible for reducing NAADPH to NAADP, a potent second messenger that evokes Ca signaling. However, specific DUOX2 activation mechanisms, particularly upon T-cell receptor (TCR) activation, remained unclear. New findings from Winterberg K. et al. identify two key kinases, PKCθ and PKA Cβ2, that directly phosphorylate and activate DUOX2, thereby accounting for basal TCR-independent and TCR-evoked NAADP/Ca signaling and dictating cytokine production. - Source: PubMed
Publication date: 2026/07/07
Chan Yi-XuanBultynck GeertSpeelman-Rooms Femke - Spondylometaphyseal dysplasia, Kozlowski type (SMDK), is an autosomal dominant skeletal disorder characterized by abnormalities of the spine, metaphyses and epiphyses. It is associated with variants in TRPV4, although the underlying molecular mechanisms remain unclear. A de novo heterozygous TRPV4 variant (c.2479C>G, p.Pro827Ala) was detected in a patient with SMDK by whole-exome sequencing, and transcriptome sequencing was performed in available family members. Expression analyses showed reduced TRPV4 transcript and protein levels associated with the p.Pro827Ala variant. Cellular functional assays further showed decreased intracellular Ca2+ concentrations without detectable changes in plasma membrane localization. In addition, ATP2B1 and PRKCQ were downregulated. To further investigate the pathogenic mechanism, a heterozygous knock-in Trpv4P827A/+ mouse model was generated using CRISPR/Cas9. Trpv4P827A/P827A homozygous mice exhibited significant skeletal developmental delay, and transcriptome profiling revealed dysregulated expression of homeobox, zf_C2H2, and forkhead transcription factor families during early development. Collectively, these findings expand the spectrum of pathogenic TRPV4 variants and provide mechanistic insights into the pathogenic effect of TRPV4 p.Pro827Ala in SMDK, supporting improved clinical diagnosis and future functional studies. - Source: PubMed
Teng CongcongHe MingZhang ChaoYang JuhuaJiang TaoYang YuechengZhou XiaoyanFeng NaCai XilunNi JunxueShi HongZhang Jie - The advent of third-generation sequencing, particularly Oxford Nanopore Technologies (ONT), has revolutionized epigenetic studies by enabling direct detection of DNA methylation modifications and single-base resolution profiling of methylation patterns. While this technology has been predominantly utilized in human and bacterial research, its applications in livestock and poultry remain limited. In this study, we employed ONT sequencing to construct comprehensive 5-methylcytosine modification maps for ten representative pig breeds, explored the mechanism of high altitude adaptive methylation and allele-specific methylation events in these pigs. - Source: PubMed
Publication date: 2026/07/10
Jiang Yi-FanGuo YiYao Wen-YeQiu AoWang Chong-LongXu Ru-HaiZhang QinFang Ling-ZhaoDing Xiang-Dong - Rising drug resistance necessitates genomic selection to enhance parasite resistance in sheep. Copy number variations (CNVs) constitute structural genomic alterations that influence livestock traits by modifying gene dosage. This study aimed to identify candidate CNVs that differentiate between Haemonchus contortus-resistant and susceptible Rideau Arcott ewe lambs through comprehensive whole genome sequencing (WGS) analysis. - Source: PubMed
Publication date: 2026/06/16
Jawad HamzaOsonowo OlufemiGilleard John SThompson SeanMiar YounesManafiazar Ghader