STAT3 (phospho-Ser727) Antibody
- Known as:
- STAT3 (phosphorilated-Ser727) Antibody
- Catalog number:
- abx000188
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- STAT3 (phospho-Ser727) Antibody
Related genes to: STAT3 (phospho-Ser727) Antibody
- Gene:
- STAT3 NIH gene
- Name:
- signal transducer and activator of transcription 3
- Previous symbol:
- -
- Synonyms:
- APRF
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-08
- Date modifiied:
- 2019-04-23
Related products to: STAT3 (phospho-Ser727) Antibody
Related articles to: STAT3 (phospho-Ser727) Antibody
- Brassica rapa L (Turnip), an edible plant, has been employed to remedy for various conditions like headaches, pyrexia, and inflammatory-related illness such as rheumatisms, and edema. Traditional usage offer anecdotal evidence, but comprehensive research is necessary to validate these claims scientifically. In order to provide a clear evidence of B. rapa's traditional application, this study aimed to evaluate the analgesic, anti-pyretic, and anti-inflammatory potentials of the methanolic extract of B. rapa leaves (BRMLE) along with comprehensive phytochemical characterization. The analgesic and anti-pyretic action of BRMLE was assessed in rats by using tail flick and hot plat tests, as well as using sub-cutaneous brewer's yeast-induced pyrexia model, respectively. Meanwhile, for validating the extract's anti-inflammatory potential, the carrageenan-induced rat paw edema model was employed. BRMLE was administered by oral gavage at safe doses: 100 mg/kg and 200 mg/kg. Thirty-nine compounds were tentatively identified from BRMLE by UPLC/MS/MS mainly are flavonoids, phenolics and glucosinolate group. GC/MS analyses yield the identification of fifteen compounds whereas glucoberteroin represents 87.61%. Glucobrassicin, cetyl palmitate, P-coumaric acid and luteolin were isolated from BRMLE. In hot plate and tail flick tests, BRMLE significantly increases latency response (P < 0.001), compared to control and standard. BRMLE (200 mg/kg) revealed anti-pyretic action by regulating the rat's rectal temperature. Moreover, its anti-inflammatory effect was evident through alleviating paw swelling, oxidative stress, histopathological alterations, and inflammatory mediators including p-STAT3, IL-1β, JAK, MCP1, TNF-α, and iNOS. These findings validated the analgesic, antipyretic, and anti-inflammatory properties of BRMLE that could be attributed to its diverse phytochemical compounds. - Source: PubMed
Publication date: 2026/05/13
El-Abd Eman A WBaraka Sara MEl-Gendy Zeinab AKorany Reda M SDeabes Doaa A H - Diabetic cognitive impairment (DCI) is a common neurological complication of diabetes for which effective treatments remain lacking. Naringenin possesses antioxidant, anti‑inflammatory, and neuroprotective properties, but its mechanism of action in DCI remains unclear. This study aimed to investigate whether naringenin protects against high glucose‑induced neuronal injury via the STAT3 signalling pathway. - Source: PubMed
Publication date: 2026/05/12
Wu YaliChen HongWang XieChang ZeSun HuihuiXia ChangqingWan Yong - The signaling lymphocytic activation molecule family member 8 (SLAMF8) is predominantly expressed on the surface of macrophages and participates in modulating tumor immune microenvironment. However, the role of SLAMF8 in tumor-associated macrophages (TAMs) in gastric cancer (GC) remains unclear. - Source: PubMed
Publication date: 2026/05/16
Wu YiZhang XudongTang ZixiangLi FangjianWu LinZhou He - Down syndrome (DS) features impaired cortical neurogenesis and excess gliogenesis, yet the temporal regulatory events driving this imbalance remain unclear. Here, we combine multi-timepoint transcriptomic analyses from publicly available datasets, network modelling, and machine-learning prioritization, with validation in isogenic human iPSC-derived cerebral organoids, to identify a discrete pathogenic window at 90 days in vitro (DIV 90). Across five developmental stages, REST target genes were preferentially dysregulated in DS organoids. WGCNA revealed a DS-associated module at DIV-90 that strongly overlapped with REST targets, and two orthogonal machine-learning approaches converged on six REST-regulated hub genes-CSTB, MCM3AP, PFKL, POFUT2, PRMT2, and RWDD2B. In trisomic organoids, REST mRNA and nuclear protein were markedly reduced at DIV-90, accompanied by diminished DCX expression and activation of NFIA and STAT3, suggesting a neurogenic-to-gliogenic fate transition. These findings suggest REST dysfunction as a potential temporal regulator of lineage imbalance in DS and highlight REST-linked networks as potential targets for early developmental intervention. - Source: PubMed
Publication date: 2026/05/16
Huang TanLim Chong-TeikLi WeiFakurazi SharidaMason John OCheah Pike-SeeLi YiLing King-Hwa - Regulation of body weight and glucose homeostasis includes the coordinated activity of hypothalamic neurons and adipocytes within a neuroendocrine network whose dysfunctions underlie obesity, insulin resistance, and type 2 diabetes (T2D). The neuronal surface P antigen (NSPA) is a plasma membrane protein with characteristics of an E3 ubiquitin ligase encoded by the unique gene Zzef1, which has been linked to T2D. NSPA's original discovery in neurons, as a cell-surface cross-reacting autoantigen of anti-P antibodies that associate with cognitive dysfunctions in patients with systemic lupus erythematosus, focused its study on hippocampal-mediated memory processes. Anti-P effects and NSPA-KO mice revealed that NSPA contributes to glutamatergic transmission and synaptic plasticity through mechanisms involving ubiquitylation processes coupled to the stability of NMDAR at the synaptic density. However, NSPA is also expressed in hypothalamic neurons, where glutamatergic synapses and NMDAR function are pivotal to the neuroendocrine control of metabolic and energy balance. Transcriptomics suggests an extended expression of NSPA in metabolically relevant peripheral tissues, including the adipose tissue. Here, we investigated whether body weight regulation and energy homeostasis involve NSPA. - Source: PubMed
Publication date: 2026/05/16
Espinoza C SofíaVivero ArielBarreto ÁngelÁlvarez-Indo JavieraMorales AndreaCabrera GermánDíaz-Valdivia NicoleVicuña LucasGonzález AlfonsoKerr Bredford