RYR2 (phospho-Ser2809) Antibody
- Known as:
- RYR2 (phosphorilated-Ser2809) Antibody
- Catalog number:
- abx000169
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- RYR2 (phospho-Ser2809) Antibody
Related genes to: RYR2 (phospho-Ser2809) Antibody
- Gene:
- RYR2 NIH gene
- Name:
- ryanodine receptor 2
- Previous symbol:
- ARVD2
- Synonyms:
- ARVC2, VTSIP
- Chromosome:
- 1q43
- Locus Type:
- gene with protein product
- Date approved:
- 1989-12-07
- Date modifiied:
- 2019-04-23
Related products to: RYR2 (phospho-Ser2809) Antibody
Related articles to: RYR2 (phospho-Ser2809) Antibody
- RNA therapeutics hold strong potential for treating genetic disease, yet progress is often limited by delivery, stability, and safety concerns. Here, we profile respiratory safety and cellular uptake of an inhaled siRNA targeting the cardiac RyR2 gene, which is responsible for catecholaminergic polymorphic ventricular tachycardia (CPVT), delivered via inhalation with calcium phosphate nanoparticles (CaP NPs). Barrier integrity, cytotoxicity, siRNA uptake, and immune activation, were assessed using a human 3D normal bronchial epithelial model (NHBE) under Air-Liquid Interphase (ALI) and dendritic cells (DCs), tested in monoculture and in co-culture. Barrier function, measured by transepithelial electrical resistance (TEER), remained stable after 48 h of exposure to 400 nM siRNA RyR2, scramble control, or CaP NPs, indicating preserved epithelial performance. Confocal imaging showed efficient internalization of Cy5-labeled siRNA in both mono- and co-cultures. Cytokine profiling revealed IL-8 release across all conditions in NHBE and NHBE + DC models, with IL-6 and TNF-α limited to immune-competent co-cultures; IFN-γ was below the limit of detection. No cytotoxicity was observed. Together, these data demonstrate that CaP NP-mediated delivery achieves robust siRNA uptake without compromising airway barrier integrity, while eliciting only modest, context-dependent immune responses (primarily IL-8 and TNF-α in the presence of DCs). This work supports the respiratory safety and translational potential of inhaled RyR2-targeting siRNA for CPVT. - Source: PubMed
Publication date: 2026/04/15
Bettinsoli ValeriaErlacher MagdalenaGalbiati ValentinaMarinovich MarinaCorsini EmanuelaWilflingseder Doris - Ventricular fibrillation (VF) and pulseless ventricular tachycardia (VT) are rare causes of pediatric out-of-hospital cardiac arrest (OHCA), especially in toddlers. Within VT, catecholaminergic polymorphic ventricular tachycardia (CPVT) is an uncommon but potentially fatal channelopathy that may present as collapse during emotional or physical stress. - Source: PubMed
Publication date: 2026/04/13
Disla Cuevas AbiezerTran ChantelChung SunHeeDaya Mohamud - - Source: PubMed
Publication date: 2026/04/10
Bergeman Auke TLauffer PeterHerkert Johanna Cvan den Heuvel Frederik M AClur Sally-Ann BVermeer Alexa M CGroffen Alexander J AJongbloed Jan D HKrapels Ingrid P CSchroer ChristianEijsbouts Sabine C MVolders Paul G Avan der Pas VincentTian ShanshanZhu Hai-LeiWang RuiwuEstillore John PaulWilde Arthur A Mvan der Werf ChristianChen S R Waynevan der Crabben Saskia N - Acanthopanax sessiliflorus (A. sessiliflorus) extract has been used in various traditional Chinese medicines and compound preparations for the treatment of arrhythmia. Our preliminary studies have demonstrated that A. sessiliflorus extract exerts significant protective effects against arrhythmia induced by barium chloride. The present study aims to elucidate the bioactive components of A. sessiliflorus and to investigate the underlying mechanisms by which it mitigates barium chloride-induced arrhythmia. - Source: PubMed
Publication date: 2026/04/01
Zhang ChungeHuang ShuaiZhang WenxinTeng HongboShao YunaZhang YihuaRen ShihangWu QiZhao YanYan Zhaowei - Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmogenic syndrome in which exercise stress testing is the primary method for provoking adrenergically mediated ventricular arrhythmias. Traditional exercise testing protocols, such as the Bruce protocol, may lack sensitivity, leading to missed diagnoses and undertreatment, whereas early pilot data suggest that a sudden high-intensity Burst protocol may better unmask arrhythmias. - Source: PubMed
Publication date: 2026/04/08
Naderi BornaLi Christopher O YDavies BriannaKallas DaniaLaksman Zachary W MFranciosi SoniaSanatani ShubhayanKrahn Andrew DRoston Thomas M