c-Jun (phospho-Thr239) Antibody
- Known as:
- c-Jun (phosphorilated-Thr239) Antibody
- Catalog number:
- abx000134
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- c-Jun (phospho-Thr239) Antibody
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Related articles to: c-Jun (phospho-Thr239) Antibody
- The COVID-19 pandemic profoundly affected global physical and psychological well-being. In addition to the loss of lives, lockdowns led to widespread declines in quality of life, particularly in mental health. While some individuals struggled, others showed resilience. This study investigated how changes in life conditions during lockdown-across physical, psychological and social domains-impacted mental health and well-being. A sample of 184 university students (82.6% female; M = 22.8, SD = 4.09) reported perceived improvements or deteriorations in these areas. Their responses were analysed in relation to psychological outcomes. The study also examined the mediating roles of emotion regulation strategies-cognitive reappraisal and expressive suppression-and hope. Although previous research emphasised the protective role of emotion regulation and hope in reducing anxiety and depression, findings from this study revealed that the psychological impact of lockdown was the strongest predictor of mental health and well-being. Emotion regulation strategies did not significantly mediate these effects. In contrast, hope emerged as the only effective mediator, reducing the negative psychological consequences of lockdown and enhancing resilience and coping. These results underscore the importance of cultivating hope as a central psychological resource to support individuals in managing prolonged adversity and maintaining psychological well-being. - Source: PubMed
Tommasi MarcoArnò SimoneSaggino Aristide - The longitudinal relationship between frailty phenotype and CKD development, and the modifying role of genetic CKD risk in this association, remains unclear. Research on simple, noninvasive and quantifiable CKD prediction models incorporating frailty is limited. - Source: PubMed
Ruan Yong-XiangGuo Da-ChuanLiu Wen-HaoOu Jia-ManGuo QiGao Jing-WeiCai Yang-WeiWu Mao-XiongLiang Xiao-TianCai Jie-WenLiu Pin-MingWang Jing-FengZhang Hai-FengChen Yang-Xin - Misgendering transgender people in healthcare contributes to fear of discrimination and stigmatisation, and transgender health inequality. Much of the language used to describe biology is discussed in a cisnormative manner. We explored the language used in a clinical skills laboratory, where pelvic mannequins with external genitalia were used. - Source: PubMed
Kwon DowanMackay KirstyBrew ChristaHartland Jo - Microglial cells are key players in maintaining brain homeostasis and responding to pathological conditions. Their multifaceted roles in health and disease have garnered significant attention in the context of neurodegeneration. In recent years, single-cell transcriptomic techniques have provided unprecedented insights into microglial heterogeneity, revealing distinct subpopulations and gene expression patterns associated with neuroprotection or neurotoxicity. Here, we dissect the transcriptomic landscape of microglia by leveraging human single-nuclei RNA sequencing datasets from multiple neurodegenerative conditions, including Amyotrophic Lateral Sclerosis, frontotemporal dementia, Alzheimer's disease, aging, and Parkinson's disease. This integrative analysis identifies distinct microglial subpopulations, reflecting functional heterogeneity across diseases and reveals a shared cross-disease microglial transcriptional program associated with inflammatory and neurodegenerative processes. Using a machine learning framework, we further demonstrate that this transcriptional program enables robust discrimination between neurodegenerative and control samples. Experimental validation in primary microglia isolated from a mouse model of Niemann-Pick disease type C, also known as juvenile Alzheimer's disease, supports the conservation of key components of this program and highlights Spp1 as a biomarker of disease-associated microglia states. Overall, this study provides an improved portrait of microglia transcriptional remodeling across neurodegenerative disorders and offers a framework for identifying conserved molecular features that may inform therapeutic strategies aimed at modulating microglial activity to mitigate disease progression and foster neuroprotection. - Source: PubMed
Palma AlessandroStefanelli RobertaTrenta FrancescoProjetti ChiaraMassa GretaCanterini SoniaFiorenza Maria Teresa - This study investigated adolescent same-sex friendship conflict trajectories and their associations with social-emotional adjustment in a sample of Chinese adolescents (N = 2001, 51.8% boys) from Grades 6 (Wave1, M = 12.31 years old, SD = 0.49) to 10. Using latent class growth analysis, three distinct trajectories of friendship conflict frequency were identified: low-slightly increasing, low-sharply increasing, and high-decreasing-stable. Consistent with an escalation hypothesis, the low-sharply increasing group exhibited a greater increase in depressive symptoms but not interpersonal relationships over time compared to the low-slightly increasing group; the high-decreasing-stable group demonstrated a greater decrease in peer rejection (i.e., "recovery hypothesis") compared to the other two groups, while simultaneously maintaining stable, higher levels of depression and loneliness (i.e., "scar hypothesis"). The findings highlight the developmental heterogeneity in friendship conflict frequency and the importance of understanding the effects of friendship conflict from a dynamic perspective. - Source: PubMed
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