SOX6 293T Cell Transient Overexpression Lysate(Denatured)
- Known as:
- SOX6 293T Cell Transient Overexpression Lysate(Denatured)
- Catalog number:
- H00055553-T01
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- SOX6 293T Cell Transient Overexpression Lysate(Denatured)
Related genes to: SOX6 293T Cell Transient Overexpression Lysate(Denatured)
- Gene:
- SOX6 NIH gene
- Name:
- SRY-box 6
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-02-15
- Date modifiied:
- 2015-11-23
Related products to: SOX6 293T Cell Transient Overexpression Lysate(Denatured)
Related articles to: SOX6 293T Cell Transient Overexpression Lysate(Denatured)
- Cardiac contractility is regulated by two myosin heavy chain (MHC) protein isoforms, and β, encoded by the and genes. The intronic regions of these genes encode the microRNAs and , which are key regulators of cardiac hypertrophy. Functionally relevant long non-coding RNAs (lncRNAs) have also been identified at these loci, such as those transcribed in the antisense direction from the gene, including the primary transcript () originating from an internal promoter. Additionally, , another cardiac sarcomeric myosin gene, serves as a precursor for . - Source: PubMed
Publication date: 2026/08/07
Červenák ZdenkoČervenák FilipValášková SimonaChomaničová NikolaKatreničová NikoletaHulman MichalGažová AndreaKyselovic Jan - The development of the dentate gyrus (DG) of the hippocampus is protracted over time in comparison with other brain regions such as hippocampal cornus ammoni or neocortex, extending over the first postnatal weeks. During DG postnatal development, neural stem cells (NSCs) will remain to generate the adult neurogenic niche that will sustain granule neuron (GN) production throughout life. NSCs in the DG divide to generate intermediate progenitor cells (IPCs), whose highly regulated dynamics of self-renewal or cell cycle exit decisions still remain poorly understood. Sox5 is a transcription factor (TF) essential for the establishment of adult NSCs, however, its potential role in Sox5 expressing IPCs during DG development remains unexplored. In this study, we demonstrate that conditional loss of Sox5 during embryonic development leads to critical alterations in cell proliferation and survival in IPCs. Specifically, following Sox5 loss, IPCs exhibit a shortening of S-phase duration in late postnatal and juvenile adult stages. Furthermore, these alterations in IPC cell cycle dynamics could be behind the defects in GN differentiation observed in Sox5-defective mice that ultimately leads to subtle morphological changes in DG architecture. Finally, we demonstrate that the additional loss of one Sox6 copy, a closely related TF to Sox5, lead to more profound disruptions in DG morphology than the one observed upon Sox5 loss. Overall, these findings point to a prominent role for Sox5 in combination with Sox6 in IPC cell cycle progression and GN maturation during postnatal DG development. - Source: PubMed
Publication date: 2026/07/23
Tirado-Melendro PaulaLi LinglingMedina-Menéndez CristinaJurado-Angulo PilarRodríguez-Martín PilarGarcía-Redondo LauraBilińska KatarzynaMorales Aixa V - The antler primary growth center, located at the distal tip of the growing antler, comprises five consecutive tissue zones beneath the velvet skin. Because the outermost reserve mesenchyme contains blastema progenitor cells with multipotent differentiation capacity, antler regeneration recapitulates embryonic skeletal development through endochondral ossification (ECO). The molecular mechanisms governing cell fate decisions and tissue morphogenesis across these zones remain poorly understood. - Source: PubMed
Publication date: 2026/07/27
Xi XiCao XinyueZhou YuyingTian ZichenHou NanqiLi ZuoyangZhou ZhenweiLi XiangyanSu Hang - Deer antler is the only mammalian organ capable of periodic complete regeneration. Its astonishing growth rate-reaching several centimeters per day-provides a unique model for research in tissue regeneration and developmental biology. This rapid growth relies on the protective and signaling functions of the skin, as well as the vigorous proliferation and differentiation capacity of mesenchymal cells. Although previous studies have identified some key factors involved in antler growth, systematically comparing the transcriptomic profiles of these two core tissues (skin and mesenchyme) to identify candidate genes regulating their synergistic growth is crucial for deciphering the molecular mechanisms underlying this "ultra-fast" growth. - Source: PubMed
Publication date: 2026/07/27
Bi XiaodanLiu BingLi BingZhao MeirongTian HuiminChen Jianxing - Osteoarthritis (OA) and osteoporosis (OP) are prevalent conditions with a complex relationship, yet their shared epigenetic mechanisms remain poorly understood. While genes like , , and have been implicated in both diseases, the specific role of individual CpG sites has not been fully characterized. We investigated CpG methylation in these genes using bisulfite pyrosequencing of peripheral blood DNA from n = 96 postmenopausal women: n = 24 with comorbid OA and OP, n = 34 with OA, and n = 38 healthy controls. Methylation differences were analyzed using statistical tests and logistic regression. Comorbid patients showed significant hypermethylation at two CpG sites compared to the OA-only group (p = 0.0007 and p = 0.042). Conversely, one site was hypomethylated in the OA-only group relative to controls (p = 0.03). A regression model combining three sites and one site demonstrated predictive value for comorbid disease, with an AUC of 0.696. These findings identify site-specific methylation of and as a molecular signature associated with comorbid OA and OP, offering new insights into their shared etiology. - Source: PubMed
Publication date: 2026/06/23
Tyurin Anton VYalaev Bulat IAkhiiarova Karina EGalina Ilmira ILi JieKhusainova Rita I