EEF1B2 Antibody
- Known as:
- EEF1B2 Antibody
- Catalog number:
- abx005048
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- EEF1B2 Antibody
Related genes to: EEF1B2 Antibody
- Gene:
- EEF1B2 NIH gene
- Name:
- eukaryotic translation elongation factor 1 beta 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-13
- Date modifiied:
- 2015-09-11
Related products to: EEF1B2 Antibody
Related articles to: EEF1B2 Antibody
- Lactate metabolism-related reprogramming is closely associated with colon adenocarcinoma (COAD) progression, but related key molecules remain unclear. This study integrated the colorectal cancer single-cell RNA sequencing dataset GSE231559, which served as a single-cell reference and integrated it with bulk RNA-seq data from TCGA-COAD to screen lactate metabolism-related candidate genes. Epithelial cells showed higher lactate metabolism-related transcriptional scores. An overlap-based screening strategy was applied, encompassing three gene sets: epithelial markers associated with lactate metabolism, dysregulated transcripts in the TCGA colon adenocarcinoma cohort, and genes within the co-expression module correlated with the lactate score. This analysis prioritized 14 genes for subsequent investigation. RPS2 and EEF1B2 were selected for further validation. Public database analysis and immunohistochemistry of paired tissues from 50 patients with COAD showed that RPS2 and EEF1B2 were highly expressed in tumor tissues. In HT-29 cells, siRNA-mediated knockdown of RPS2 or EEF1B2 reduced proliferation and migration, increased apoptosis, and decreased HK2, PFK1, PKM2, and LDHA expression, with stronger changes after double knockdown. RPS2 knockdown also increased residual glucose levels and reduced lactate release. Co-immunoprecipitation showed that RPS2 and EEF1B2 were detected in the same protein complex, and EEF1B2 overexpression partially rescued the effects of RPS2 knockdown. These findings suggest that RPS2 and EEF1B2 are associated with glycolysis-related malignant phenotypes in HT-29 cells. - Source: PubMed
Publication date: 2026/06/15
Hou JianbinDong YangyangQian Huiyang - The association between cervical cancer (CC) and venous thromboembolism (VTE) has been well documented, but the underlying molecular characteristics remains unclear. The aim of this study was to explore the shared genetic features and regulatory networks of CC and VTE. - Source: PubMed
Publication date: 2026/07/08
Lin XijinXie LantingShao KongfengJing JunjieChen Haiyan - Cytoskeletal remodeling, including microtubule severing, is essential for neurite growth and structural plasticity. However, the regulatory mechanisms that control the microtubule-severing activity of katanin A1 (KATNA1) remain incompletely understood. Here, we identify a novel interaction between eukaryotic translation elongation factor 1 beta (EEF1B2) and KATNA1 and show that this protein pair regulates microtubule dynamics and neurite outgrowth. Proteomic screening and biochemical validation (GST pull-down and co-immunoprecipitation) demonstrated that EEF1B2 interacted with KATNA1, with strongest binding mapped to the KATNA1 AAA + ATPase domain. In COS7 cells, EEF1B2 potentiated KATNA1-dependent microtubule severing, whereas EEF1B2 knockdown attenuated KATNA1-driven microtubule loss. In primary cortical neurons, EEF1B2 enhanced KATNA1-induced neurite outgrowth and branching, and these effects were KATNA1-dependent. Together, these findings identify EEF1B2 as a modulator of KATNA1 activity and provide new insight into the molecular mechanisms governing microtubule remodeling and neurite growth. - Source: PubMed
Publication date: 2026/04/17
Wu ZengzhiYan JiajieDeng TingtingDong JiaoMeng ZhichaoZhu JiehaoChen MuZhang GuoweiTan WeiTan Minghui - The eukaryotic elongation factor 1 (eEF1) complex is essential for translational elongation and comprises eEF1A and eEF1B subunits. eEF1Bα, encoded by EEF1B2, functions as the complex’s guanine nucleotide exchange factor. Recently, biallelic loss-of-function variants in EEF1B2 have been implicated in a rare neurodevelopmental disorder characterized by global developmental delay, intellectual disability, behavioral abnormalities, and occasional seizures. We describe two siblings from consanguineous parents who present with profound developmental delay, severe speech impairment, and additional neurodevelopmental features. Whole-exome sequencing identified a homozygous nonsense variant in EEF1B2, classified as likely pathogenic. These cases expand the phenotypic spectrum of EEF1B2-related disease. - Source: PubMed
Publication date: 2026/01/14
Ketenci-İşlek SerapÜrel-Demir GizemUtine Gülen EdaŞimşek-Kiper Pelin Özlem - Colorectal cancer often develops from adenomas over years, necessitating early intervention. Myeloid-derived suppressor cells (MDSCs) are major immune suppressive cell types in colon cancer development from adenomas through early inflammation-induced emergency myelopoiesis. Cannabidiol (CBD) is reported to function in psychosis, coronavirus infection and some cancers through immune regulation. However, its target and underlying mechanisms in colorectal adenomas are unknown. - Source: PubMed
Publication date: 2026/01/03
Pan JieZhao LixinDu HaojieZhu YuyuSun XiaofanXu QiangCheng HaiboChen HongqiSun Yang