HSP90AA1 Antibody
- Known as:
- HSP90AA1 Antibody
- Catalog number:
- abx000695
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- HSP90AA1 Antibody
Related genes to: HSP90AA1 Antibody
- Gene:
- HSP90AA1 NIH gene
- Name:
- heat shock protein 90 alpha family class A member 1
- Previous symbol:
- HSPC1, HSPCA
- Synonyms:
- Hsp89, Hsp90, FLJ31884, HSP90N
- Chromosome:
- 14q32.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-27
- Date modifiied:
- 2016-10-11
Related products to: HSP90AA1 Antibody
Related articles to: HSP90AA1 Antibody
- Parkinson's disease, a neurodegenerative disorder, is characterized by the degeneration of dopaminergic neurons and the accumulation of α-synuclein, both of which are aggravated by oxidative stress. This study utilized rotenone-treated SH-SY5Y cells to assess cell viability, ROS levels, and mitochondrial function. RNA-seq, mass spectrometry, and Co-IP analyses identified BDNF-regulated proteins linked to oxidative stress. In rotenone-induced PD mice, evaluations were made of motor performance, neuronal degeneration, and protein expression. Results showed that a 36-h exposure to 0.5 µM rotenone significantly increased ROS production, impaired mitochondrial function, and caused cellular damage in SH-SY5Y cells, effects which were reversed by BDNF overexpression. In mice, BDNF overexpression in the substantia nigra pars compacta alleviated PD-like symptoms. Co-IP analysis showed that BDNF modulates NRF2 and its associated proteins via HSP90AA1. These findings demonstrate that BDNF alleviates rotenone-induced oxidative stress in PD models through the HSP90AA1/NRF2 pathway, offering critical insights into the pathogenesis and potential therapeutic strategies for Parkinson's disease. - Source: PubMed
Publication date: 2026/05/02
Xie SongCao WanwanGuo JunZhao MengfanWang LinxiLiang FeitengWang Zhao - Two isoforms of the 90-kDa heat shock protein (Hsp90), stress-inducible Hsp90α and constitutively expressed Hsp90β, function in mammalian cells as molecular chaperones that promote the folding of specific client proteins involved in essential cellular processes and regulatory pathways. A number of Hsp90 client proteins take part in cancer progression, and the inhibition of Hsp90 induces the degradation of oncogenic client proteins and cancer cell death. Hsp90 inhibitors specific for individual Hsp90 isoforms have a significant potential for the development of anticancer therapeutics due to reduced toxicity. Cells with knocked-out genes encoding Hsp90 isoforms represent excellent cellular models to investigate the rearrangement of the cell chaperone machinery in response to the suppression/loss of the Hsp90 isoforms. - Source: PubMed
Petrenko ViktoriaVrublevskaya VeronikaSkarga YuriZhmurina MariyaMorenkov Oleg - Dengue virus (DENV) remains a significant public health threat, yet no effective antiviral therapies are currently available. Based on TCM theory, the treatment of dengue emphasizes the principles of clearing heat and detoxifying, cooling blood and dissipating blood stasis. Yinqiao Powder (YQS), a famous clearing heat and detoxifying formula, has a good curative effect on the virus-induced diseases, and theoretically has potential value in the treatment of dengue. - Source: PubMed
Publication date: 2026/04/15
Guo ZhuolinHe XuemeiChen BingZhang ZhihengYu JingtaoZhao WeiChen XiangdongHu YunguangZuo JianpingYu LinzhongFan ChunlinLiu Junshan - Gastrodia elata Blume (G. elata) is a valuable traditional Chinese medicine (TCM) that has been widely used in China. We systematically reviewed tonic and life-extending records in ancient medical literature, as well as the life-prolonging and senescence-delaying effects identified in modern pharmacological research, to provide a theoretical basis for the clinical application and product development of G. elata in tonification and anti-aging. Scientific databases, including CNKI (Chinese literature) and PubMed, were searched to gather relevant literature on the anti-aging effects of G. elata. The targets of the main chemical components of G. elata were predicted and collected through a database, and the intersection of compound targets and disease targets was identified. Protein-protein interaction network analysis, Gene Ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to explore the potential mechanisms underlying the anti-aging effects of G. elata. The record of G. elata demonstrates a definitive life-extending effect. Modern pharmacological studies have confirmed that it prolongs the lifespan of short-lived animals and slows the aging processes of the brain, skin, bone, and skeletal muscle in animals. Network pharmacology analysis identified 15 common targets shared between candidate target genes of G. elata and anti-aging target genes. TP53, ESR1, EP300, SIRT1, STAT3, CCND1, HDAC2, MDM2, PPARG, TNF, and HSP90AA1 were identified as core genes in the protein-protein interaction (PPI) network analysis. KEGG enrichment analysis indicated that the anti-aging mechanisms of G. elata may be associated with chemical receptor activation, insulin resistance, the citric acid cycle, the PPAR signaling pathway, the glucagon signaling pathway, and the thyroid hormone signaling pathway. This article summarizes previous studies and modern research on the anti-aging effects of G. elata, suggesting that it holds significant potential for clinical applications in anti-aging. - Source: PubMed
Publication date: 2026/04/20
Wang RuoyingXin ChenranLiu WencongCheng ZhiqiangZhu HongyanHan Jihong - Climate-driven aquatic heatwaves pose an increasing threat to fish populations by inducing prolonged thermal stress. However, the resilience of teleosts to chronic heat exposure and their capacity for recovery remains poorly understood. This study investigated the effects of chronic high-temperature exposure on juvenile zebrafish (Danio rerio). Fish were exposed for 60 days to one of four treatments: (T1) 28°C control; (T2) 28°C for 30 days followed by 34°C for 30 days; (T3) 34°C for 30 days followed by 28°C for 30 days (recovery); and (T4) constant 34°C. Growth, liver morphology and the expression of 14 genes related to heat-shock response, growth and liver function by qPCR were assessed. Chronic exposure to 34°C (T4) significantly reduced body mass after 60 days. Genes associated with heat-shock response (hsp70, hsp90aa1, serpinh1b), liver function (got1) and growth (igf1, ghra) were consistently upregulated in T4 fish at Days 30 and 60, while expression in recovery fish (T3) returned to control levels by Day 60. Histopathological changes in T3 and T4 fish, including hepatocellular vacuolation, mirrored these gene expression patterns. Together, these findings demonstrate that prolonged thermal stress impairs growth and alters liver metabolism. Moreover, the identified hepatic and molecular responses represent promising biomarkers of chronic heat stress, with potential applicability to other fish species. - Source: PubMed
Publication date: 2026/04/29
Adzijovski MoniqueSchultz Aaron GBergfeld JemmaAfonso Luis O B