RhoA Antibody
- Known as:
- RhoA Antibody
- Catalog number:
- abx000657
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- RhoA Antibody
Related genes to: RhoA Antibody
- Gene:
- RHOA NIH gene
- Name:
- ras homolog family member A
- Previous symbol:
- ARH12, ARHA
- Synonyms:
- RhoA, Rho12, RHOH12
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-19
- Date modifiied:
- 2019-04-23
Related products to: RhoA Antibody
Related articles to: RhoA Antibody
- Dynamic plasma membrane remodeling is fundamental for cleavage, signal transduction, and cytoskeletal organization during mammalian embryogenesis. Although oocyte activation triggers membrane remodeling and elevates phosphatidylinositol (4,5)-bisphosphate (PIP2), the underlying regulatory mechanisms remain elusive. Here, we identify phosphatidylinositol-4-phosphate 5-kinase type I alpha (PIP5K1A), an enzyme responsible for generating PIP2, as a key regulator of membrane remodeling in porcine embryos. Maternal depletion of PIP5K1A impaired oocyte activation, disrupted actin organization and vesicle trafficking, and blocked early development. Conversely, excessive expression of PIP5K1A caused accumulation of PIP2-enriched vesicles that trapped filamentous actin and reduced membrane contractility, resulting in cleavage failure. Structure-function analysis revealed that residue Q169 mediates PIP5K1A interaction with RhoA, the PIPB motif anchors it to the plasma membrane, and the activation loop drives catalytic activity and is required for proper RhoA membrane localization and is associated with endocytic abnormalities when mutated. PIP5K1A also sustains phospholipase C-inositol trisphosphate-Ca signaling, coordinating vesicle fusion and cytoskeletal remodeling. During cytokinesis, PIP5K1A-enriched membrane clusters serve as hubs for RhoA recruitment. These findings suggest PIP5K1A as a central organizer of lipid signaling, actin dynamics, and membrane contractility to drive successful early embryonic development in mammals. - Source: PubMed
Publication date: 2026/05/15
Zhan Cheng-LinLee Song-HeeNie Zheng-WenCui Xiang-Shun - Piezo ion channels, notably Piezo1 and Piezo2, are key mechanosensors that transduce mechanical forces into intracellular signals, playing indispensable roles in digestive physiology. These channels regulate essential functions such as intestinal motility, epithelial barrier integrity, bile secretion, and host-microbiota balance. Emerging evidence links aberrant Piezo signaling to a wide range of gastrointestinal disorders, including functional bowel diseases, inflammatory conditions, and digestive cancers. However, translating these insights into therapeutic applications remains challenging. Most current findings are derived from animal models or studies, which do not fully recapitulate human tissue complexity. Advanced human-relevant platforms, such as organoids and organ-on-a-chip systems, are needed to bridge this translational gap. Furthermore, Piezo1 and Piezo2 play both overlapping and distinct roles in gastrointestinal pathophysiology, necessitating selective modulation strategies. While Piezo1 promotes processes such as epithelial remodeling and tumor invasion via pathways like RhoA/ROCK and YAP/TAZ, Piezo2 is more associated with sensory neuron activity, immune modulation, and tumor aggressiveness. The lack of specific agonists and inhibitors, especially for Piezo2, further limits its clinical translation. Lastly, Piezo channels are deeply integrated into complex molecular networks involving focal adhesions, cytoskeletal dynamics, and transcriptional regulation. This review synthesizes current advances in the mechanobiology of Piezo channels within the digestive system and highlights future directions for mechanistically-informed, Piezo-targeted therapies. - Source: PubMed
Publication date: 2025/11/07
Yan XiangyunZeng WeijianMa PeitaoYao JunpengMa TingtingLi Ying - The p75 neurotrophin receptor (p75) is a critical regulator of diverse biological processes. Depending on the cellular context, p75 can promote trophic or degenerative signaling, which can influence a broad spectrum of pathological conditions, including neurodegenerative diseases, inflammatory/infectious conditions, and various central and peripheral nervous system injuries. These attributes of p75 and its widespread, frequently upregulated expression on affected cells and tissues, make it a compelling therapeutic target. Among various therapeutic targeting strategies, the first-in-class small molecule p75 modulator, LM11A-31, has emerged as a leading candidate and has been evaluated in 62 published preclinical studies spanning 26 distinct disease and injury models. - Source: PubMed
Publication date: 2026/05/28
Langness Vanessa FSimmons Danielle AKaur SukhneetMassa Stephen MLongo Frank M - [This corrects the article DOI: 10.1016/j.cellin.2026.100310.]. - Source: PubMed
Publication date: 2026/05/15
Duan DongZheng XuZhou YanqiuCui MengmengLi YunyiCui XiaoxianYang YuyingChen MinWu HuanyuChen XinMeng Guangxun - Cartilage fibrosis plays a critical role in the onset and progression of osteoarthritis (OA), and although RhoA is a well-known small GTPase that regulates cytoskeletal reorganization, its role in OA progression remains inadequately explored. - Source: PubMed
Publication date: 2026/05/14
Xu YizhouXu ShuyiLi JiayiWang ShichengLiang JieWang JiaqiWang XianghaiDeng GangZhu LixinGuo Jiasong