RhoA Antibody
- Known as:
- RhoA Antibody
- Catalog number:
- abx000657
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- RhoA Antibody
Related genes to: RhoA Antibody
- Gene:
- RHOA NIH gene
- Name:
- ras homolog family member A
- Previous symbol:
- ARH12, ARHA
- Synonyms:
- RhoA, Rho12, RHOH12
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-19
- Date modifiied:
- 2019-04-23
Related products to: RhoA Antibody
Related articles to: RhoA Antibody
- Sensorineural hearing loss (SNHL) is a prevalent clinical disorder in otorhinolaryngology, with cochlear ischemia/reperfusion (I/R) injury-induced hair cell apoptosis being a core pathogenic mechanism. Ginsenoside Rb1 (Rb1), a major active component of Panax ginseng, exhibits potent anti-apoptotic and neuroprotective effects, but its role and underlying mechanism in cochlear I/R injury remain elusive. - Source: PubMed
Publication date: 2026/09/05
Chang WeiHuang JiangLiao QiongYang XinzhuBin JiWu Wenke - - Source: PubMed
Publication date: 2026/09/05
Chen XueranZhang ShangrongWang ZhenWang FengsongCao XinwangWu QuanZhao ChenggangMa HuihuiYe FangWang HongzhiFang Zhiyou - Most cancer deaths result from metastasis, yet only a subset of tumor cells can complete this process. Polyaneuploid cancer cells (PACCs), which arise via endoreplication under stressors such as hypoxia, are implicated as metastatic drivers, but how they acquire this capacity remains unclear. Here, we show that under extreme self-generated hypoxia, the polyaneuploid subset of PC3 prostate cancer cells upregulates a hypoxia-responsive, HIF-1α-dependent RhoA signaling axis that promotes aerotaxis, a behavior predictive of intravasation during metastasis. We observe an enrichment of PACCs using a membrane-based culture system in which extreme, self-generated radial oxygen gradients emerge as cellular oxygen demand exceeds supply, recapitulating key features of the tumor microenvironment. Under these conditions, PACCs exhibited elevated HIF-1α and RhoA expression relative to non-PACCs. Disruption of either HIF-1α or RhoA attenuates aerotaxis, with RhoA expression suppressed upon HIF-1α inhibition, suggesting a functional HIF-1α- dependent RhoA pathway selectively enhanced in the PACC state. Quantitative analysis of nuclear morphology further reveals that nuclear circularity and solidity, morphology metrics associated with nuclear rounding and boundary organization, increase with and saturate at high nuclear area. Notably, the hypoxic PACC population exhibits significantly greater nuclear circularity and solidity compared to non-PACCs, suggesting increased rounding and stabilization of the enlarged nuclear architecture characteristic of PACCs under extreme hypoxia. Together, these findings reveal a new functional role for HIF-1α- dependent RhoA signaling in regulating aerotaxis in polyaneuploid cancer cells, which may enable aerotactic escape from hypoxic tumor cores and entry into oxygen-rich vasculature. Additionally, the association between elevated RhoA signaling and increased nuclear circularity at larger nuclear area suggests a potential link between hypoxia-responsive migration and maintenance of enlarged nuclear architecture in the PACC state. Collectively, these characteristics highlight PACCs as a hypoxia-adapted subpopulation with relevance for anti-metastatic therapeutic strategies. - Source: PubMed
Publication date: 2026/09/04
Hosny NoreenLi ShengkaiGatenby Robert APienta Kenneth JBrown Joel SHammarlund Emma UYu ChenQu JunleAustin Robert HAmend Sarah R - Pulmonary hypertension (PH) is a multifaceted disorder characterized by the crucial involvement of activated hypoxia-inducible factors (HIFs). Recent investigations have unveiled HIFs' ability to orchestrate a wide array of signaling cascades, encompassing voltage-gated potassium channels, non-selective cation channels (NSCCs), Ca/PKC/MAPKs, PI3K/Akt, RhoA/ROCK, Notch, VEGF, and miRNA pathways. The interplay of these signaling cascades drives critical events, namely hypoxic pulmonary vasoconstriction (HPV) and hypoxic pulmonary vascular remodeling (HPVR), which collectively contribute to the pathogenesis of PH. This review summarizes the role of HIF signaling in hypoxic pulmonary vasoconstriction, pulmonary vascular remodeling, metabolic reprogramming, inflammation, non-coding RNA regulation, and emerging HIF-targeted therapies. - Source: PubMed
Publication date: 2026/09/02
Sun YinhuiDing RongzhenSu XianliQin LiWang LihuaiYi JianHu RuichengYou ShuyingTan ZhenfeiDai Aiguo - To elucidate whether Danggui Sini Decoction (DGSD) relieves sciatica by downregulating transient receptor potential (TRP) channels involved in peripheral sensitization. - Source: PubMed
Publication date: 2026/09/03
Zhang DiZhuang Zi-FengLin Shao-ZiChen Zen-NiChen Hong-LingGu Jun-YanHao Yu-TingLi Yi-XuanChen Jia-XuZhao Guo-Ping