PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- Known as:
- PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- Catalog number:
- H00025796-T02
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- PGLS 293T Cell Transient Overexpression Lysate(Denatured)
Related genes to: PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- Gene:
- PGLS NIH gene
- Name:
- 6-phosphogluconolactonase
- Previous symbol:
- -
- Synonyms:
- 6PGL
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-20
- Date modifiied:
- 2015-08-25
Related products to: PGLS 293T Cell Transient Overexpression Lysate(Denatured)
Related articles to: PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- The cochlear dimensions relevant to hearing capability generally follow a pattern of allometric scaling with body mass in mammals. Nevertheless, humans exhibit cochlear dimensions larger than expected from the body mass, and it has been proposed that this is related to encephalization. In this study, we investigate whether the link between brain mass and cochlear morphology is unique to humans and whether cranial features other than brain mass impinge on the cochlear morphology in catarrhine primates that exhibit considerable variation in brain mass. Cochlear and cranial dimensions (cochlear length, oval window area, endocranial volume, cranial size, and interaural distance) were measured on three-dimensional surface models for 30 hominoid individuals (humans, chimpanzees, gorillas, orangutans, and gibbons) and 20 cercopithecine individuals (Japanese macaques, mandrills, and baboons). Relations between cochlear and cranial variables were evaluated using generalized linear mixed model (GLMM) and phylogenetic generalized least squares (PGLS) analyses. The endocranial volume better predicts cochlear morphology than the other cranial measurements in catarrhines. Specifically, the average cochlear length per turn exhibits a strong correlation, while the oval window area exhibits a weaker correlation with the endocranial volume in both GLMM and PGLS. Humans do not deviate from the common allometric pattern of cochlear length against endocranial volume in the catarrhine primates studied here. It appears that humans do not necessarily represent an exceptional cochlear morphology in catarrhine primates after accounting for the cranial dimensions and phylogeny. Our data thus indicate that the link between endocranial volume and cochlear morphology could be a more general pattern for catarrhine primates than previously recognized. - Source: PubMed
Publication date: 2026/10/02
Kojima TakumiMorimoto Naoki - Body size represents one of the most fundamental adaptive traits in mammals, but the genetic architecture underlying the extensive body size diversification observed in the Felidae family remains largely uncharacterized. Here, we present the first comprehensive comparative genomic analysis of Felidae body size evolution using high-quality reference genomes from 17 species, including two newly reannotated genomes. Using phylogenetic generalized least squares (PGLS) analysis, we identified 35 body-size-associated genes (BAGs), most of which are functionally implicated in skeletal development, thyroid hormone synthesis, and lipid metabolism. Functional enrichment analysis revealed that positively selected genes (PSGs) in large-bodied Felidae were predominantly enriched in DNA repair pathways, whereas PSGs in small-bodied Felidae were primarily involved in energy metabolism and lipid metabolism processes. In summary, the adaptive evolution of both core signaling pathways and key functional genes has jointly driven body size diversification in Felidae. This study uncovers new molecular insights into how mammalian body size evolves, while also generating a valuable genomic dataset for subsequent functional research. - Source: PubMed
Publication date: 2026/09/22
Zhao ShihuXia TianMei XuesongQiu ChenZhang YingZhao ChaoWu XiaoyangGao XiaodongFang JiaohuiDing JianqunWang ZhenglongYang XiufengZhang Honghai - is an emerging respiratory pathogen primarily found in soil environments, yet its genomic architecture and evolutionary strategies remain poorly characterized. Here, through pan-genomic and functional analysis of 242 isolates, we reveal an open pan-genome driven by extensive horizontal gene transfer and marked functional divergence between core and accessory genomes. We identify a phylogenetically distinct lineage, designated as putative serogroup 3 (sg3), recovered from Chinese environments. This lineage diverges from canonical serogroups 1 and 2 through genome reduction (mean size 4.01 Mb), absence of plasmids, and a truncated O-antigen biosynthesis cluster lacking a key N-acetyltransferase-encoding gene (orf9). infection models across multiple human cell lines show that sg3 elicits increased host cell death and elevated proinflammatory cytokine transcription in epithelial cells compared to sg1 and sg2. Phylogenetically corrected association analyses revealed no significant link between this phenotype and individual accessory virulence factors. Instead, rank-transformed phylogenetically generalized least squares (PGLS) regression demonstrated a significant positive association with expansion of the mobilome (COG X), while intracellular trafficking (COG U) and defense (COG V) repertoires were contracted. These findings reveal a distinct pathogenic profile in sg3 that differs from the canonical serogroups, characterized by heightened inflammatory activation rather than immune evasion. Our work advances the understanding of population structure, challenges the reductionist utility of traditional serogrouping, and highlights the potential need for revised diagnostic considerations as well as continued surveillance of lineages displaying enhanced cytotoxicity and proinflammatory responses, which may be associated with mobilome expansion.IMPORTANCE is an understudied yet emerging cause of Legionnaires' disease, with a distinct soil-based ecology. Using comparative pan-genomics and functional infection assays across 242 isolates (including 39 newly sequenced from China), we identify a putative novel serogroup (sg3) that has undergone marked genome reduction (4.01 Mb) and completely lost plasmids, contrasting with near-ubiquitous plasmid carriage in sg1/sg2. Despite its streamlined genome, putative sg3 exhibits enhanced cytotoxicity in all tested human cell lines and elevated proinflammatory cytokine expression, particularly in epithelial cells. These phenotypes are not explained by individual virulence genes but are significantly associated with mobilome (COG X) expansion. Our findings question the assumption that genome reduction necessarily diminishes pathogenic potential and suggest that higher-order genomic restructuring, potentially linked to mobilome expansion, may be associated with increased inflammatory responses. Furthermore, they highlight the potential need for continued surveillance and consideration of revised diagnostic approaches to include this rare but possibly underdiagnosed lineage. - Source: PubMed
Publication date: 2026/09/22
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Publication date: 2026/08/17
Abbasi Aleena ALustig Robert ADorsey Jay FGrady Sean MLee John Y KKurtz Goldie AShabason Jacob ECengel Keith ABigelow Douglas CBrant Jason ARuckenstein Michael JRassekh Christopher HNathanson Katherine LRaper AnnaHuan YonghongAlonso-Basanta Michelle - Recognizing lineages is a central challenge in plant systematics, making it essential to explore multiple analytical tools. In this context, this study investigates how frond shape can assist in discriminating against lineages within the Scaly clade of Microgramma (Polypodiaceae), and tests whether the integration of multiple lines of evidence enables a more consistent recognition of lineages than exclusively macromorphological approaches. - Source: PubMed
Publication date: 2026/09/10
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