PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- Known as:
- PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- Catalog number:
- H00025796-T01
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- PGLS 293T Cell Transient Overexpression Lysate(Denatured)
Related genes to: PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- Gene:
- PGLS NIH gene
- Name:
- 6-phosphogluconolactonase
- Previous symbol:
- -
- Synonyms:
- 6PGL
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-20
- Date modifiied:
- 2015-08-25
Related products to: PGLS 293T Cell Transient Overexpression Lysate(Denatured)
Related articles to: PGLS 293T Cell Transient Overexpression Lysate(Denatured)
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), remains a major global health challenge and a leading cause of infectious mortality. Central to TB pathogenesis is the nuclear factor-kappa B (NF-κB) signaling network, a master regulator of inflammation, immune activation, and host defense. This review highlights the complex molecular interplay between M. tb virulence determinants and host NF-κB pathways, emphasizing how the pathogen strategically manipulates transcriptional responses to promote survival, persistence, and transmission. Early during infection, cell wall-derived muramyl dipeptide (MDP) activates the NOD2-RIP2 signaling axis, triggering canonical NF-κB activation and p50/RelA-dependent transcription of pro-inflammatory mediators essential for innate immune containment. However, persistent infection is characterized by extensive immune reprogramming. Antigen 85-derived trehalose dimycolate (TDM), biofilm-associated structures, phenolic glycolipids (PGLs), sulfatides, and the catalase-peroxidase enzyme KatG selectively suppress protective NF-κB responses through mechanisms involving p50/p50 homodimer accumulation, RelA repression, disruption of TLR2-MyD88 signaling, and inhibition of redox-dependent IKK activation. In parallel, the ESX-1-secreted ESAT-6/CFP-10 complex and stress-induced heat shock proteins drive persistent NF-κB hyperactivation, resulting in excessive cytokine production, matrix metalloproteinase release, tissue destruction, and bacterial dissemination. Furthermore, antigenic variation mediated by PE/PPE protein families continuously rewires receptor-dependent signaling pathways, preventing effective adaptive immune memory formation. Collectively, these findings reveal that M. tb does not merely evade host immunity but actively remodels NF-κB signaling dynamics through coordinated activation, suppression, and pathological hyperactivation. Understanding these compartment-specific regulatory mechanisms provides a framework for developing precision host-directed therapies aimed at enhancing antimicrobial immunity while limiting immunopathology, offering promising avenues for improved management of drug-sensitive and drug-resistant tuberculosis. - Source: PubMed
Publication date: 2026/08/11
Mehraj SafiyaAhmad Zahoor - Para-aortic paragangliomas (PGLs) are rare neuroendocrine tumors that may present with or without catecholamine hypersecretion. Their surgical management requires meticulous preoperative evaluation and careful intraoperative technique due to their proximity to major vascular structures. This report is novel in directly comparing functional and non-functional para-aortic PGLs, with an emphasis on perioperative strategy and surgical outcomes. - Source: PubMed
Publication date: 2026/06/26
Alqatta WailAl-Harethee Wasim - To evaluate outcomes of early integration of facial nerve management for facial nerve canal paragangliomas (FNC PGLs), prioritising facial nerve rehabilitation alongside tumour control. - Source: PubMed
Publication date: 2026/08/03
Braude RachelManzie Timothy GhShein GregCharters EmmaLow Tsu-Hui Hubert - Root surface morphology has been used to examine functional signals related to diet and taxonomic affinities in primates with varying degrees of success. The aim of this study is to determine if the use of the functionally significant root cervix can enhance our understanding of these relationships in catarrhines. - Source: PubMed
Sims Zana R - Paragangliomas (PGLs) are uncommon neuroendocrine tumors most commonly found in the head and neck that originate from neural crest cells. Primary pancreatic paraganglioma is exceedingly rare and has largely been described in case reports and small case series. We present the case of a 79-year-old woman with an incidental pancreatic head lesion initially favored to represent a well-differentiated neuroendocrine tumor. Endoscopic ultrasound with rapid on-site cytopathologic evaluation demonstrated neoplastic cells with neuroendocrine features. Further immunohistochemical (IHC) workup demonstrated tumor cells negative for cytokeratins and positive for GATA-3, supporting a diagnosis of paraganglioma over a well-differentiated neuroendocrine tumor. Cytokeratin immunohistochemistry should be employed alongside neuroendocrine markers in the workup of neuroendocrine tumors to avoid misdiagnosis. - Source: PubMed
Publication date: 2026/07/01
Storozuk TannerVecchio Marc