Synthetic CHRNA1 Blocking Peptide
- Known as:
- Synthetic CHRNA1 Blocking Peptide
- Catalog number:
- abx062066
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- Synthetic CHRNA1 Blocking Peptide
Related genes to: Synthetic CHRNA1 Blocking Peptide
- Gene:
- CHRNA1 NIH gene
- Name:
- cholinergic receptor nicotinic alpha 1 subunit
- Previous symbol:
- CHRNA
- Synonyms:
- -
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-25
- Date modifiied:
- 2016-02-04
Related products to: Synthetic CHRNA1 Blocking Peptide
Related articles to: Synthetic CHRNA1 Blocking Peptide
- Circadian rhythm disruption is increasingly recognized as a contributor to chronic inflammatory disorders; however, its specific significance and underlying mechanisms in chronic obstructive pulmonary disease (COPD) remain unclear. This study aimed to identify circadian rhythm-associated biomarkers in COPD and explore their diagnostic value, immune correlations, and therapeutic potential. - Source: PubMed
Publication date: 2026/07/31
Zhang LanLi ZhifeiXia TianshengYang TingtingFu JiaLu YanXu JiayiHan Kaiyu - Congenital myasthenic syndromes (CMS) are rare genetic disorders caused by pathogenic variants in proteins expressed at the neuromuscular junction. Current literature surrounding adult CMS patients remains limited, primarily derived from Western cohorts. - Source: PubMed
Publication date: 2026/07/17
Hoe Rebecca Hui MinKoh Jasmine ShiminSaini MonicaPrasad KalpanaChan Yee CheunNg Peng SoonHuei Josiah Chai YuiChong Li JieTay Karine Su ShanChen Zhiyong - CircRNAs have been linked to the pathogenesis and progression of myasthenia gravis (MG), but research on this association remains limited. This study aims to provide a new perspective for understanding the molecular pathogenesis of MG. We obtained RNA-seq data from patients with acetylcholine receptor (AChR)-positive MG and healthy individuals from the Gene Expression Omnibus (GEO) database. A bioinformatics analysis was performed to identify differentially expressed circRNAs related to MG; the circRNA that was most consistently identified in most databases as a key factor involved in MG, hsa_circ_0065149, was chosen for further analysis. AChR localized at the postsynaptic membrane of the neuromuscular junction (NMJ) plays a pivotal role in mediating synaptic signal transmission. The CHRNA1 gene, which encodes the α1 subunit of AChR and is critical for its function-was subsequently selected as the target mRNA in our investigation, whereas our prediction pipeline identified miR-330-5p as the target. For functional assays, various constructs (e.g., hsa_circ_0065149-siRNA) were transfected as described in the Methods section. The qRT‒PCR results indicated that hsa_circ_0065149 knockdown significantly upregulated miR-330-5p and downregulated CHRNA1, while the inhibition of miR-330-5p significantly upregulated both hsa_circ_0065149 and CHRNA1. We also performed functional rescue experiments to confirm the regulatory hierarchical relationships among these factors. A dual-luciferase reporter assay confirmed that hsa_circ_0065149 and CHRNA1 are direct targets of miR-330-5p. These results suggest that hsa_circ_0065149 regulates MG by mediating the ceRNA network pathway, and we reasonably hypothesize that it may further contribute to the pathological process of MG by impairing signal transmission in the NMJ. - Source: PubMed
Publication date: 2026/05/22
Liu SiyuTian QinghuaLiu ZhaojunRen YingjieYu AoqingChen BiyingZhou TianyangLi XiangWang JianjianWang LihuaZhang Huixue - Double seronegative myasthenia gravis (dSnMG) is defined as myasthenia gravis (MG) without detectable antibodies to acetylcholine receptor (AChR) and muscle-specific kinase (MuSK). Absence of a disease-specific biomarker and clinical heterogeneity can significantly complicate diagnostic pathway. This study aimed to identify cases misdiagnosed as dSnMG. - Source: PubMed
Publication date: 2026/03/19
Ivanovic VukanPeric StojanBriggs CaitlinMarjanovic AnaPesovic JovanBasta IvanaJansson JohanRandhawa SimratRajic SonjaGokhale Sankalp - Barth syndrome (BTHS) is a rare X-linked mitochondrial disorder caused by mutations in the TAFAZZIN gene, which disrupts cardiolipin (CL) remodelling and mitochondrial function. While cardiac manifestations of BTHS are well characterized in male patients, the mechanisms underlying skeletal muscle weakness and fatigability are poorly understood. - Source: PubMed
Matias CatalinaSnider Paige LSierra Potchanant Elizabeth AHuot Joshua RRaghav RahulChin Michael TConway Simon JBrault Jeffrey J