CCL26 293T Cell Transient Overexpression Lysate(Denatured)
- Known as:
- CCL26 293T Cell Transient Overexpression Lysate(Denatured)
- Catalog number:
- H00010344-T01
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- CCL26 293T Cell Transient Overexpression Lysate(Denatured)
Related genes to: CCL26 293T Cell Transient Overexpression Lysate(Denatured)
- Gene:
- CCL26 NIH gene
- Name:
- C-C motif chemokine ligand 26
- Previous symbol:
- SCYA26
- Synonyms:
- MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-09
- Date modifiied:
- 2016-10-05
Related products to: CCL26 293T Cell Transient Overexpression Lysate(Denatured)
Related articles to: CCL26 293T Cell Transient Overexpression Lysate(Denatured)
- : Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous type 2 inflammatory disease characterized by frequent postoperative recurrence despite endoscopic sinus surgery (ESS). Reliable biomarkers capable of predicting recurrence remain insufficiently validated. This study evaluates the prognostic utility of circulating biomarkers for recurrence prediction in CRSwNP, in addition to the predictive performance of the blood eosinophilia. : A prospective cohort of 69 patients with CRSwNP undergoing primary ESS was followed for up to 3 years. Periostin, eotaxin-3, procalcitonin and IL-33 were taken from blood before surgery and analyzed by ELISA technique. Clinical outcomes were assessed using SNOT-22 and Perioperative Sinus Endoscopy (POSE) scores. Statistical analyses included Spearman's correlation, the Mann-Whitney U test, the Kruskal-Wallis test, Cox proportional hazards regression, multivariable binary logistic regression, ROC analysis, and longitudinal MANCOVA. : Blood eosinophilia remained the strongest clinical predictor of recurrence (OR = 4.55, = 0.001). Serum periostin, eotaxin and procalcitonin significantly correlated with postoperative disease severity and recurrence, particularly with POSE scores at 1 and 3 years ( < 0.05). Patients with recurrence demonstrated significantly higher serum levels of these biomarkers compared with controlled patients (all < 0.001). Multivariate Cox regression identified periostin (HR = 1.033, = 0.010), eotaxin (HR = 1.554, < 0.001) and procalcitonin (HR = 1.183, < 0.001) as significant predictors of recurrence. Procalcitonin demonstrated the highest predictive performance in ROC analysis (AUC = 0.805). Longitudinal MANCOVA confirmed significant associations between periostin, eotaxin, procalcitonin, and persistent postoperative inflammatory burden over 3 years. : Circulating periostin, eotaxin and procalcitonin are promising predictors of CRSwNP recurrence and appear to contribute to prognostic accuracy. Integration of serum biomarker profiling into clinical practice may improve personalized postoperative management and risk stratification in CRSwNP. - Source: PubMed
Publication date: 2026/07/27
Florean Maria-DeliaMare CodruțaGâta AndaTrombitaș Veronica ElenaBudișan LiviuțaZanoaga OanaBerindan-Neagoe IoanaStelea Carmen GabrielaRoman AlexandraAlbu Silviu - Sumac (Rhus coriaria L., Anacardiaceae) fruit is receiving a growing attention as potential nutraceutical and cosmetic ingredient. It is appreciated either as a spice and medicinal remedy in Middle East countries. The application of fruits preparations to skin injuries emerged from ethnopharmacological studies, sustained by few experimental studies on wound healing. The present work, based on previous evidence of in vitro anti-inflammatory activity in human keratinocytes (HaCaT), is aimed at translating the in vitro effect of sumac to an in vivo model of dermatitis. - Source: PubMed
Publication date: 2026/08/26
Fumagalli MarcoMartinelli GiuliaSosa SilvioTang ZixiongCarlin MichelaEl Haddad Safwa MohebMaranta NicolePozzoli CarolaDi Lorenzo ChiaraBaron GiovannaPiazza StefanoPelin MarcoDell'Agli MarioSangiovanni Enrico - Chemokine (C-C motif) ligand 26 (CCL26), also known as eotaxin-3, is an immune-regulatory chemokine involved in inflammatory responses and immune cell recruitment. Emerging evidence suggests its expression is dysregulated across multiple malignancies, yet comprehensive pan-cancer evaluations remain limited. - Source: PubMed
Ali SIsmail MKumar PMohamed SAlyoubi WMohamed HAlamri RYasin FAbdelrahman SAlshaibi HOsman EFozilovna ABadritdnova MAkasha RAlfaki M - Eosinophilic chronic rhinosinusitis (CRS), characterized by prominent eosinophil infiltration, has the highest postoperative recurrence rate among CRS subtypes. Given the critical role of eotaxins in CRS pathogenesis, this study aimed to identify eotaxins associated with eosinophilic CRS and evaluate their correlation with surgical outcomes. Transcriptomic data from GSE36830 revealed 125 differentially expressed genes (49 up-regulated, 76 down-regulated) in CRSwNP compared to CRSsNP, with significant enrichment of eosinophil and dendritic cell infiltration pathways. Functional analysis identified chemotaxis and cell migration as key dysregulated processes in CRSwNP. Among eotaxins, CCL26 and CCL13 emerged as hub molecules from the intersection of these dysregulated pathways. In a clinical cohort of 115 CRS patients, preoperative serum CCL26 and CCL13 levels were significantly elevated in CRSwNP compared to CRSsNP (P<0.001). ROC analysis demonstrated strong diagnostic power for nasal polyps (CCL26: AUC=0.895; CCL13: AUC=0.830). Higher preoperative CCL26 levels predicted poorer symptom improvement post-surgery (standardized β=-0.564, P<0.001). In conclusion, preoperative serum CCL26 serves as both a diagnostic biomarker for CRSwNP and a prognostic indicator for surgical outcomes, with elevated levels associated with reduced symptom improvement. - Source: PubMed
Publication date: 2026/08/07
Wang XudongLiu ShunanChen JichuanZeng WantingJiang Jianguo - Mugwort () is a predominant aeroallergen for allergic rhinitis (AR) in northern China. However, the molecular changes linking local nasal mucosal inflammation with systemic alterations remain incompletely understood. This study aimed to explore the cross-level regulatory network in a mouse model of mugwort-induced AR by combining nasal mucosal transcriptomics and serum metabolomics. - Source: PubMed
Publication date: 2026/07/08
Chi JiaoniChen LinJin YuxuanSun Jin-LyuXu Yajie