NEFL Antibody
- Known as:
- NEFL Antibody
- Catalog number:
- abx008943
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- Abbexa
- Gene target:
- NEFL Antibody
Related genes to: NEFL Antibody
- Gene:
- NEFL NIH gene
- Name:
- neurofilament light
- Previous symbol:
- -
- Synonyms:
- NFL, CMT1F, CMT2E, NF68, PPP1R110
- Chromosome:
- 8p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: NEFL Antibody
Related articles to: NEFL Antibody
- Brain health disorders (BHDs) remain a concern for people with HIV (PWH) despite antiretroviral therapy access and viral suppression. The contribution of HIV to brain health is often obscured by comorbidities in high-income settings which are less prevalent in sub-Saharan Africa. Neurofilament light chain (NfL), a biomarker of axonal injury, may offer insight into underlying mechanisms. 338 virally-suppressed PWH and 250 people without HIV (PWoH) completed a Research Domain Criteria-informed battery assessing cognitive, sensorimotor, and social processing systems. Demographically-adjusted norms were derived from PWoH. Serostatus differences in impairment (≥ 1SD below the mean) were examined using multivariable logistic regression. Additional models examined associations between NfL (plasma, cerebrospinal fluid [CSF]) and task performance. PWH were similar to PWoH in age (43.9 vs. 43.5yrs), sex (female, 54 vs. 46%), and education (6.1 vs. 5.8yrs). PWH had higher odds of impairment in the cognitive control and attention (Color Trails, Symbol Digit) and sensorimotor (Grooved Pegboard) domains. Plasma NfL was associated with sensorimotor impairment in both groups. Similar trends held in CSF NfL but did not reach statistical significance, likely due to sample size (n = 85). Cognitive and sensorimotor difficulties are common in PWH in Rakai, independent of typical Western confounders. The profile of impairment differs from reports in high-income settings where declarative memory deficits are often observed. NfL was associated with sensorimotor impairment, suggesting that NfL may capture ongoing axonal injury and motor system vulnerability in PWH and PWoH. These findings suggest NfL's potential as a biomarker of sensorimotor impairment in sub-Saharan Africa. - Source: PubMed
Publication date: 2026/06/22
Ridgeway KDastgheyb Raha MEaster Rebecca EShorer Eran FAnok AggreyTomusange StephenMannarino JulieSaylor DeannaGisslen MagnusZetterberg HenrikNakasujja NoelineNakigozi GertrudePaul RobertRubin Leah H - Subcutaneous natalizumab offers greater convenience than intravenous administration, but pharmacokinetic differences have raised concerns about potential subclinical disease activity. Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP) are sensitive biomarkers of neuroaxonal damage and astroglial activation. - Source: PubMed
Publication date: 2026/06/22
Muñoz-Vendrell AlbertArroyo-Pereiro PabloLeón IsabelBau LauraMatas ElisabetRomero-Pinel LuciaRoca-Pereira SergioMartínez-Yélamos AntonioMartínez-Yélamos Sergio - Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important. - Source: PubMed
Publication date: 2026/06/01
Koerte Inga KWiegand Tim L TBonke Elena MSandmo Stian KKaufmann DavidSeer CarolineBetz Anja KDe Luca AlbertoSeitz-Holland JohannaMuehlmann MarcCente MartinElad DoronMonteiro Thiago SantosSchwarz-Mörtl BettinaGaubert MaloKaufmann ElisabethBonfert Michaela VHeinen FlorianLin Alexander PShenton Martha ETripodis YorghosBahr RoaldFilipcik PeterGooijers JolienLeemans AlexanderSochen NirSwinnen Stephan PPasternak Ofer - Alzheimer's disease shows prolonged prodromal stability before accelerating decline, yet molecular markers resolving this heterogeneity are limited. Using pseudo-progression analysis of 1.3 million SEA-AD single nuclei (84 donors), we identify a reproducible biphasic astrocytic trajectory anchored to prostaglandin D2 synthase (PTGDS), with a statistically resolved donor-level inflection (quadratic β₂ = -2.27, p = 0.006; vertex CPS 0.47). The same directional change is independently reproduced in external brain proteomics (ROSMAP and Banner; AD versus control p = 3.4 × 10⁻³), and the biphasic pattern reconciles previously conflicting CSF reports as stage-dependent. In ADNI CSF, downstream NEFL tracks cognitive decline strongly and LCN2 weakly, whereas PTGDS itself is tissue-restricted and not a stand-alone predictor. We propose, but do not establish, that post-inflection PTGDS attenuation accompanies LCN2-linked inflammation and NGFR suppression. These data position astrocytic PTGDS as a candidate stage marker, not a causal driver, of the compensatory-to-vulnerable shift in the aging brain - the astrocytic PTGDS inflection (CPS 0.47). - Source: PubMed
Publication date: 2026/06/10
Kim YoungOukHeo WooMyungPark Se JinKim YoungChulCho Ye EunLee Ye-WonKim JungYeon - Neurofilament light chain protein and glial fibrillary acidic protein have been proposed as potential blood biomarkers for multiple sclerosis. However, their diagnostic and prognostic values across different subtypes and disease activity patterns remain unclear. - Source: PubMed
Publication date: 2026/06/20
Yang ChengJiang ChenxiWang YirenHu YihengLi YunfeiZhou PingWang Youhua