ANGPTL7 293T Cell Transient Overexpression Lysate(Denatured)
- Known as:
- ANGPTL7 293T Cell Transient Overexpression Lysate(Denatured)
- Catalog number:
- H00010218-T03
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- ANGPTL7 293T Cell Transient Overexpression Lysate(Denatured)
Related genes to: ANGPTL7 293T Cell Transient Overexpression Lysate(Denatured)
- Gene:
- ANGPTL7 NIH gene
- Name:
- angiopoietin like 7
- Previous symbol:
- -
- Synonyms:
- CDT6, AngX
- Chromosome:
- 1p36.22
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-07
- Date modifiied:
- 2016-10-05
Related products to: ANGPTL7 293T Cell Transient Overexpression Lysate(Denatured)
Related articles to: ANGPTL7 293T Cell Transient Overexpression Lysate(Denatured)
- The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) has been increasing globally, and data indicate that ferroptosis participates in the pathogenesis of MAFLD. Angiopoietin-like protein 7 (ANGPTL7) is a novel secretory glycoprotein that participates in the pathogenesis of many metabolic diseases. However, the role of ANGPTL7 in MAFLD has been poorly investigated. A total of 194 participants were enrolled, including 104 participants with MAFLD (MAFLD) and 90 healthy controls (Cons). Baseline characteristics and serum biochemical parameters were collected. Serum levels of ANGPTL7, inflammatory factors, and ferroptosis-related proteins were measured by enzyme-linked immunosorbent assay (ELISA). Liver biopsy tissues were obtained from six participants with nonalcoholic steatohepatitis and the trimmed liver tissues from five healthy liver transplant donors; H&E, Masson, Perls Prussian blue, and immunohistochemical staining were performed. Compared with healthy Con, BMI, SBP, and DBP were significantly increased, and ALT, AST, TC, TG, LDL-C, GLU, HbA1c, INS, Hcy, and UA levels were all significantly increased, while HDL-C levels were decreased in MAFLD patients (MAFLD vs. Con, p < 0.05 or p < 0.001). Serum levels of ANGPTL7, TNF-α, IL-6, ACSL4, Keap-1, HO-1, and ferritin were significantly increased, while IL-10, GPX4, and Nrf2 levels were decreased in MAFLD patients when compared with the Con group (MAFLD vs. Con, all p < 0.001). Immunohistochemical staining showed that the expression of ANGPTL7, Keap-1, and HO-1 was significantly increased, while Nrf2 expression was significantly decreased in liver tissue from the MAFLD group (MAFLD vs. Con, all p < 0.05). ROC analysis showed that the optimal cut-off value of serum ANGPTL7 for MAFLD was 9.75 ng/mL, suggesting it could serve as a potential biomarker for the diagnosis of MAFLD. ANGPTL7 may participate in the pathogenesis of MAFLD, and serum ANGPTL7 has predictive value for the diagnosis of MAFLD. - Source: PubMed
Bai JingGao QianLiu YanGao MingmingZhou Yaru - Heart failure (HF) is a major cardiovascular complication of type 2 diabetes mellitus (T2DM), yet reliable biomarkers for early risk stratification remain limited. We investigated the prospective association between plasma angiopoietin-like protein 7 (ANGPTL7) and incident HF, and examined the extent to which this relationship is mediated by insulin resistance (IR). - Source: PubMed
Song YanjunChen XinyueChang Zhen'geWang ChunyueZheng ZhihaoLin ZhangyuLi BowenZhu ChenWang XiaoFu RuiDou Kefei - Angiopoietin-like 7 (ANGPTL7) is a member of the angiopoietin-like protein family, which plays critical physiological roles in angiogenesis, tissue homeostasis maintenance, inflammatory signaling, glucose metabolism and lipid metabolism. Meanwhile, ANGPTL7 is also implicated in the regulation of numerous pathological processes and disease development. In recent years, several studies have demonstrated that ANGPTL7 is differentially expressed in various types of tumors and it may regulate tumourigenesis, tumor angiogenesis, invasion, and metastasis through diverse mechanisms. Additionally, ANGPTL7 has been implicated in the diagnosis and prognosis of tumor patients, suggesting its potential as a novel biomarker for tumor prediction. In this review, we provide a comprehensive overview of the structure and function of ANGPTL7, as well as its role and underlying mechanisms in tumor development. Furthermore, we discuss potential future research directions and clinical applications of ANGPTL7 in oncology. - Source: PubMed
Publication date: 2026/02/26
Fan XiaoxiaoZheng WenxinTian XianglongWu Xiaolin - Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) being the most common type. , a protein integral to cytoskeletal organization and cellular signaling, has not been extensively studied in NSCLC. - Source: PubMed
Publication date: 2026/01/07
Zhang YuqiQiang RongDing MengyangWang Lin - Endometriosis is a chronic and debilitating gynecological disorder affecting approximately 10% of women of reproductive age worldwide (190 million), often leading to chronic pain, infertility, and considerable economic burden. Despite being recognized for over a century, endometriosis remains challenging to diagnose, thus there is a need for simpler diagnostic methods, and blood biomarker-based approaches-successful in other diseases-are a promising option. While some biomarkers show elevated serum levels in endometriosis, study outcomes vary, and their specificity and sensitivity remain suboptimal. Many of these biomarkers are also linked to other inflammatory conditions, limiting their diagnostic value for endometriosis. To expand the current biomarker landscape, we performed unbiased RNA sequencing analysis of patient-derived endometriosis tissue samples, representing all major subtypes (peritoneal, ovarian, and deep infiltrating), with the aim of identifying potential subtype-specific biomarkers. Our analysis revealed significant differences in gene expression profiles between normal eutopic endometrium and various types of endometriosis. We also observed significant differences in immune cell composition, with notable alterations in the abundance of natural killer (NK) cells and M2 macrophages across subtypes. Importantly, we validated the increased expression of PLA2G2A, ANGPTL7, and PLA2G5 using ELISA in individual endometriosis subtypes, supporting their potential as non-invasive, subtype-specific diagnostic biomarkers pending further validation. This study represents a meaningful advancement in the understanding of subtype-specific molecular and immunological pathways in endometriosis. Our findings are well aligned with current research and provide novel insights into the pathophysiology of distinct endometriosis subtypes. The identified biomarkers could contribute to the development of an improved, subtype-informed diagnostic algorithm for endometriosis. - Source: PubMed
Publication date: 2026/01/12
Lisá ZFanta MKokavec JJanoštiak R