NEFL 293T Cell Transient Overexpression Lysate(Denatured)
- Known as:
- NEFL 293T Cell Transient Overexpression Lysate(Denatured)
- Catalog number:
- H00004747-T01
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- NEFL 293T Cell Transient Overexpression Lysate(Denatured)
Related genes to: NEFL 293T Cell Transient Overexpression Lysate(Denatured)
- Gene:
- NEFL NIH gene
- Name:
- neurofilament light
- Previous symbol:
- -
- Synonyms:
- NFL, CMT1F, CMT2E, NF68, PPP1R110
- Chromosome:
- 8p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: NEFL 293T Cell Transient Overexpression Lysate(Denatured)
Related articles to: NEFL 293T Cell Transient Overexpression Lysate(Denatured)
- Post-traumatic epilepsy (PTE) is a delayed complication of traumatic brain injury (TBI), but its biological predictors remain insufficiently defined. This study evaluated the dynamic profile of serum biomarkers of neuroinflammation, neuroimmune activation and neuronal injury after moderate TBI, as well as their predictive value for late post-traumatic seizures and PTE during 12 months of follow-up. - Source: PubMed
Kurbanov AAbdullaeva YBadritdinova MAbdullaeva VKhalimova FMarwan I - Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and the presence of restrictive, repetitive patterns of behaviour. Although its exact aetiology remains multifaceted and partially understood, recent clinical interest has shifted towards neurobiological substrates, specifically neuroaxonal and astroglial integrity. This study aims to compare serum levels of Neurofilament Light Chain (NfL), Glial Fibrillary Acidic Protein (GFAP), Tau and S100B between children with ASD and healthy controls, while investigating the influence of these biochemical variables on autism severity and behavioural manifestations. - Source: PubMed
Dedeoğlu Zeynep NurUzun NecatiKılınç İbrahimKılıç Ahmet Osman - Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. - Source: PubMed
Publication date: 2026/08/03
Vigneswaran SinthujahVerberk Inge M WBoonkamp LynnIn 't Veld LisanneKoel-Simmelink Marleen J AAntwi-Berko Danielvan Unen LuukRousset RebeccaClaessen ThomasZwan Marissa DOssenkoppele RikWilson DavidLemstra Afina WPijnenburg Yolande A Lvan der Flier Wiesje MMuller MajonMattace-Raso FrancescoPapma Janne MSeelaar HarroTeunissen Charlotte Evan Harten Argonde C - Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder, yet it remains unclear whether cortical architecture can reveal biologically distinct subtypes with distinct molecular and serum biomarker signatures. Two hundred PD patients and 121 healthy controls underwent structural MRI. Subject-specific cortical similarity networks were constructed using Morphometric INverse Divergence (MIND), and subtypes were identified with HYDRA. Spatial patterns were linked to regional gene expression from the Allen Human Brain Atlas through partial least squares regression, followed by functional and cell-type enrichment analyses. Serum neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) were quantified using single-molecule array assays. No significant MIND differences emerged when PD patients were analysed as a single group. HYDRA identified two subtypes (ARI = 0.85) with divergent cortical organization that only partially overlapped with conventional motor phenotypes. Cluster 1 exhibited temporo-parietal MIND increases associated with synaptic and oligodendroglial signatures, without serum biomarker associations. Cluster 2 showed widespread fronto-cingulate MIND reductions enriched for mitochondrial, lysosomal, and proteostatic pathways, including the KEGG Parkinson's disease pathway, and these reductions correlated with higher serum NfL and GFAP. These findings reveal two biologically distinct PD subtypes with divergent molecular architecture and systemic neurodegeneration beyond conventional motor phenotyping. - Source: PubMed
Publication date: 2026/07/28
Bianco Maria GiovannaCalomino CamillaBonacci Maria CelesteCaligiuri Maria EugeniaCristiani Costanza MariaScaramuzzino LuanaBuonocore JolandaArcuri Pier PaoloQuattrone AldoQuattrone Andrea - Individuals with type 2 diabetes (T2D) have increased risk of acute myocardial infarction (AMI). Cardiovascular risk within T2D is heterogeneous and not fully explained by conventional risk factors, highlighting the need for improved biological risk stratification. - Source: PubMed
Publication date: 2026/08/11
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