Recombinant Human VCAM1 /CD106 Protein
- Known as:
- Recombinant Human VCAM1 /CD106 Protein
- Catalog number:
- vc-765
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Proxinobio
- Gene target:
- Recombinant Human VCAM1 /CD106 Protein
Related genes to: Recombinant Human VCAM1 /CD106 Protein
- Gene:
- VCAM1 NIH gene
- Name:
- vascular cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- CD106
- Chromosome:
- 1p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2016-10-05
Related products to: Recombinant Human VCAM1 /CD106 Protein
Related articles to: Recombinant Human VCAM1 /CD106 Protein
- Cardiac xenotransplantation represents a promising strategy to address the shortage of donor hearts, yet endothelial cell dysfunction remains a major obstacle to long-term graft survival. Using integrated single-cell RNA sequencing in a porcine-to-primate xenotransplantation model, we identified a VCAM-1 endothelial subpopulation as the primary endothelial subtype susceptible to acute rejection, characterized by its selective depletion after transplantation. To protect this population, we develop VCAM-1-targeted nanoparticles (VTNs) integrating three functional modules: (i) a VCAM-1-binding peptide identified, (ii) a self-assembling peptide module by one-bead one-compound screening for precise targeting that forms protective nanofibrous coatings, and (iii) localized delivery of mycophenolate mofetil (MMF) for immune modulation. VTN reduces immune cell adhesion by 73% ( < 0.001) and extends xenograft survival nearly fourfold, from 6.7 to 27.0 days. These findings establish VCAM-1 endothelial cells as a therapeutic target and highlight VCAM-1-targeted nanomedicine as a promising approach to improve xenograft outcomes. - Source: PubMed
Publication date: 2026/07/08
Li Yi-JingZhang HangSun ZheXing KaiHua XiumengLi PeiyuanChen XiaoMo HanSong Jiangping - Cell adhesion molecules (CAMs) are essential regulators of tissue architecture, inflammation, and cellular signaling, mediating interactions between cells and their microenvironment. Major CAM families include intercellular adhesion molecules (ICAMs), vascular cell adhesion molecules (VCAMs), platelet endothelial cell adhesion molecules (PECAMs), and selectins. Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are expressed on activated endothelial cells and promote firm leukocyte adhesion through interactions with integrins such as lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18) and macrophage-1 antigen (CD11b/CD18). Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) facilitates leukocyte transmigration across endothelial junctions. P-selectin (platelet selectin) and E-selectin (endothelial selectin) mediate the initial rolling of leukocytes via binding to P-selectin glycoprotein ligand-1 (PSGL-1). In traumatic brain injury (TBI), endothelial activation and blood-brain barrier (BBB) disruption upregulates these adhesion molecules, promoting leukocyte recruitment and infiltration into the injured brain. This process amplifies neuroinflammation through the release of cytokines, chemokines, and reactive oxygen species, contributing to oxidative stress, mitochondrial dysfunction, and neurodegeneration. In this review, we highlight the roles of ICAM-1, VCAM-1, PECAM-1, and selectins in TBI pathogenesis, with particular emphasis on ICAM-1-mediated leukocyte transmigration. - Source: PubMed
Publication date: 2026/07/07
Lizon Thalia BarriosRussell RamdhanPoovanthodi Yemin AMangatt SriyaCabral MichaelCordero Felipe BilderJohn DarielleMartinez SofiaMoidunny ShamsudheenMuneer P M Abdul - Elucidating the mechanisms underlying rheumatic heart disease (RHD) accompanied by mitral annulus calcification (MAC) facilitates the identification of sensitive diagnostic biomarkers and the development of targeted therapeutic strategies. Proteomic analysis offers an approach to characterizing protein expression changes, thereby contributing to the clarification of pathogenesis in both RHD and cardiac valve calcification. Time-saving and high-efficiency enzymatic digestion methods are thus highly desirable for reliable and high-performance proteomic analysis. This study developed a quasi-immobilized enzyme digestion (QIED) technology based on honeycomb-like magnetic carbon material (FeC@C-650) with a pore size of 100-150 nm, which enables rapid enzymatic digestion in 5 min (200-fold faster than traditional methods) by ultrahigh enzyme adsorption capability. The developed method was applied to proteomic analysis of mitral valve tissues from 7 patients, and 3128 proteins were identified, which clarified the three-phase pathological progression (calcified, thickened, and normal tissues) of RHD-related calcification and revealed core hub genes (e.g., , , ) and the synergistic pathway of "inflammation regulation-protein translation-cell remodeling". This study provides methodological support and molecular targets for the precise diagnosis and targeted therapy of RHD complicated with MAC. - Source: PubMed
Publication date: 2026/07/07
Yan ZhichaoZhai JunyuGe QiyueWang ZhenxinSong BaichuanWang RuihongZhang LingyiZhang Weibing - Decabromodiphenyl ether (BDE-209) is a widely used flame retardant and persistent environmental contaminant. However, the overlap between predicted BDE-209-related targets and ulcerative colitis (UC)-associated molecular signatures has not been systematically evaluated. - Source: PubMed
Publication date: 2026/07/06
Zhang YueZhang HaiHu DanliZhang HailongWang DaHong ZiyangSu SiChen Ling - Fabry disease (FD) is an X-linked lysosomal storage disorder caused by α-galactosidase A deficiency, leading to globotriaosylceramide accumulation, endothelial activation, inflammation, and progressive cardiac involvement. In this exploratory cross-sectional study, we investigated whether vascular cell adhesion molecule-1 (VCAM-1), an endothelial activation biomarker, is associated with early cardiac phenotypic changes in FD. - Source: PubMed
Publication date: 2026/07/06
Lino Danielli Oliveira da CostaMeneses Gdayllon Cavalcantede Almeida Igor MoreiraMartins Alice Maria CostaVasconcelos Amanda Jorge de Sousade Lima Carlos José MotaRocha Ricardo Paulo de SousaDaher Elizabeth De Francescoda Silva Junior Geraldo Bezerra