Recombinant Human CD200 /OX-2 Protein
- Known as:
- Recombinant Human CD200 /OX-2 Protein
- Catalog number:
- cd-757
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Proxinobio
- Gene target:
- Recombinant Human CD200 /OX-2 Protein
Related genes to: Recombinant Human CD200 /OX-2 Protein
- Gene:
- AOX2P NIH gene
- Name:
- aldehyde oxidase 2 pseudogene
- Previous symbol:
- AOX2
- Synonyms:
- AOH2
- Chromosome:
- 2q33.1
- Locus Type:
- pseudogene
- Date approved:
- 2002-04-03
- Date modifiied:
- 2016-10-05
- Gene:
- CD200 NIH gene
- Name:
- CD200 molecule
- Previous symbol:
- MOX1, MOX2
- Synonyms:
- MRC, OX-2
- Chromosome:
- 3q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-08-27
- Gene:
- CD200R1 NIH gene
- Name:
- CD200 receptor 1
- Previous symbol:
- MOX2R
- Synonyms:
- OX2R, HCRTR2, CD200R
- Chromosome:
- 3q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-12
- Date modifiied:
- 2016-10-05
- Gene:
- CD200R1L NIH gene
- Name:
- CD200 receptor 1 like
- Previous symbol:
- -
- Synonyms:
- CD200RLa, CD200R2
- Chromosome:
- 3q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-10-08
- Date modifiied:
- 2015-11-11
- Gene:
- CHCHD7 NIH gene
- Name:
- coiled-coil-helix-coiled-coil-helix domain containing 7
- Previous symbol:
- -
- Synonyms:
- MGC2217, COX23
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-19
- Date modifiied:
- 2016-10-05
Related products to: Recombinant Human CD200 /OX-2 Protein
Related articles to: Recombinant Human CD200 /OX-2 Protein
- Inhibitory and activating immune receptors play a key role in modulating the amplitude and duration of immune responses during infection and in maintaining immune balance in homeostatic conditions. The CD200 Receptor (CD200R) gene family in humans encodes one inhibitory receptor, CD200R1, and one putative activating member, CD200R1 Like (CD200R1L). It is demonstrated that CD200R1L is endogenously expressed by human neutrophils and activates cellular functions such as reactive oxygen species (ROS) production via Syk, PI3Kβ, PI3Kδ, and Rac GTPase signaling. Phylogenetic analysis shows that CD200R1L is present in many species among vertebrates, ranging from birds to primates, suggesting that evolutionary conservation of this receptor is critical for protection against co-evolving pathogens. The duplication event that generated CD200R1L from CD200R occurred several times throughout evolution, supporting convergent evolution of CD200R1L. In our phylogenetic trees, CD200R1L has longer branch lengths than CD200R1 in most species, suggesting that CD200R1L is evolving faster than CD200R1. It is proposed that CD200R1L represents a hitherto uncharacterized activating receptor on human neutrophils. - Source: PubMed
Publication date: 2021/04/22
Pascoal Ramos M InêsKeşmir CanStok Jorn EGeerdink RubenSatravelas NikolaosWesterlaken Geertje H AMeyaard Lindevan der Vlist Michiel