Recombinant human SEMA4D /CD100 Protein
- Known as:
- Recombinant H. sapiens SEMA4D /CD100 Protein
- Catalog number:
- cd-733
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Proxinobio
- Gene target:
- Recombinant human SEMA4D /CD100 Protein
Related genes to: Recombinant human SEMA4D /CD100 Protein
- Gene:
- SEMA4D NIH gene
- Name:
- semaphorin 4D
- Previous symbol:
- SEMAJ, C9orf164
- Synonyms:
- CD100, coll-4, FLJ39737
- Chromosome:
- 9q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-06-25
- Date modifiied:
- 2016-10-05
Related products to: Recombinant human SEMA4D /CD100 Protein
Related articles to: Recombinant human SEMA4D /CD100 Protein
- Semaphorin 4D (Sema4D)/(CD100) expression is upregulated in different human cancers, and it is associated with poor prognosis; however, its prognostic value in B-acute lymphoblastic leukemia (B-ALL) remains unclear. We aimed to study the prognostic value of Sema4D expression to predict response to induction therapy in pediatric patients with B-ALL. Sixty newly diagnosed pediatric patients with B-ALL were enrolled, and their peripheral mononuclear cells (PBMCs) were isolated for assessment of Sema4D expression by multiparametric flow cytometry before initiating therapy. Then, we followed up with the patients for their response to induction therapy. Sema4D expression is significantly higher in non-responders to induction therapy than in responders. Using the receiver operating characteristic (ROC) curve, Sema4D expression > 18% significantly identifies patients at risk for induction failure. Logistic regression analyses confirmed that Sema4D expression is significantly associated with poor response to induction therapy. - Source: PubMed
Publication date: 2026/04/17
Elkholy Rasha AEl Amrousy DoaaElgezawy Doaa EElkholy Reem ATaha OlaEltoukhy Abeer AElaskary Eman - Single-cell fixed RNA profiling (FLEX) is a novel technique that captures RNA expression in frozen tissues at a single-cell resolution. We applied FLEX to mouse model of liver fibrosis progression and regression to identify novel antifibrotic targets. - Source: PubMed
Publication date: 2026/02/11
Duc Pham MinhThuy Le Thi ThanhHai HoangVan Bao TranHa Nguyen ThiAnh Pham TuanIkenaga HirokoFujii HidekiYoshida KanakoEnomoto MasaruUchida-Kobayashi SawakoYuasa HidetoMatsubara TsutomuHuyen Vu ThuongCheng YiYamagishi RyotaOhtani NaokoOikawa DaisukeTokunaga FuminoriKisseleva TatianaBrenner David AIwakiri YasukoGracia-Sancho JordiKawada Norifumi - Psoriasis is an autoimmune systemic disease of not entirely understood pathogenesis. It remains a significant therapeutic challenge and, due to its various comorbidities, has a remarkable detrimental effect on patients' wellbeing. Semaphorins (Sema) are a group of transmembrane, cell surface-attached and secretory proteins that might play an important role in psoriasis due to their presence on keratinocytes and the ability to stimulate the proinflammatory cytokine production. - Source: PubMed
Publication date: 2026/03/12
Baran AnnaStepaniuk AnnaHermanowicz Justyna MagdalenaSieklucka BeataPawlak KrystynaPawlak DariuszFlisiak Iwona - Periodontitis is a chronic inflammatory disease that severely affects oral and general health. N7-methylguanosine (m7G) methylation plays critical roles in regulating gene expression and cellular functions. Methyltransferase-like 1 (METTL1), a core component of the m7G methyltransferase complex, has been implicated in various diseases, but its role in periodontitis remains unclear. - Source: PubMed
Publication date: 2026/03/13
Huang Yong-SongZhang Zi-HaoZhou Mei-YunGeng Lin-YaWang Ting-Ting - Tumor-derived exosomes critically mediate metastasis, yet how specific cargoes reprogram the vasculature remains unclear. In gastric cancer (GC), we identify TAGLN2 as a key exosomal mediator. It is co-overexpressed in GC cells and tumor-associated endothelial cells (TECs), and its high endothelial expression correlates with lymph node metastasis and poor prognosis. Functionally, GC-derived exosomes deliver TAGLN2 to endothelial cells (ECs), orchestrating angiogenesis, EndoMT, and the disruption of endothelial junctions. In vivo, exosomal TAGLN2 accelerated tumor growth and lung metastasis by generating abnormal, leaky vasculature and hypoxia. Mechanistically, exosomal TAGLN2 initiates a novel signaling axis: it transcriptionally upregulates NRP1 via c-Jun/SP1 and concurrently induces SEMA4D expression. TAGLN2 then interacts with both NRP1 and SEMA4D to nucleate a stable cytoplasmic ternary complex. This complex dually activates YAP by competitively disrupting NRP1-YAP binding to release YAP from cytoplasmic retention, and simultaneously suppressing Hippo-mediated degradation, operating independently of the canonical SEMA4D-PlexinB1-RhoA/ROCK pathway. Therapeutically, targeting the TAGLN2 axis synergized with both cisplatin and bevacizumab, potently suppressing tumor progression by impairing neovascularization and promoting vascular normalization. Clinically, exosomal TAGLN2 levels were significantly elevated in GC patient serum. Our study delineates a complete exosome-to-vasculature signaling axis and positions TAGLN2/NRP1/SEMA4D/YAP module as an integrated diagnostic and therapeutic target against metastatic GC. - Source: PubMed
Publication date: 2026/03/13
Yu ShuqiZhuo JiajiaHong XiaoquanRao ShihaoYe YafangKang DandanPeng HuifangZhuo Huiqin