Recombinant Human IL4R /CD124 Protein
- Known as:
- Recombinant Human IL4R /CD124 Protein
- Catalog number:
- il-728
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Proxinobio
- Gene target:
- Recombinant Human IL4R /CD124 Protein
Related genes to: Recombinant Human IL4R /CD124 Protein
- Gene:
- IL4R NIH gene
- Name:
- interleukin 4 receptor
- Previous symbol:
- -
- Synonyms:
- CD124
- Chromosome:
- 16p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-06
- Date modifiied:
- 2017-07-07
Related products to: Recombinant Human IL4R /CD124 Protein
Related articles to: Recombinant Human IL4R /CD124 Protein
- Disseminated coccidioidomycosis (DCM) is an often fatal and otherwise intractable condition requiring lifelong antifungal treatment. We have previously shown that a deranged polarization of CD4+ T cells toward a Th2 phenotype can exist in the context of DCM. Here we studied a large population of subjects to determine the frequency of abnormal Th2 skewing of CD4+ T cells in patients with coccidioidomycosis and to identify underlying genetic mechanisms supporting this phenotype. - Source: PubMed
Publication date: 2026/04/21
Thauland Timothy JNagarajan Smriti SStephens Alexis VJensen Samantha LSrivastava AnvikshaMoreno Lastre Miguel AAhn Terrie SBun ChantanaTrump Michael TJohnson Royce HThompson Iii George RGarcia-Lloret Maria IArboleda Valerie AButte Manish J - Endometriosis (EM) is a prevalent gynecological disorder linked to pelvic pain, menstrual disturbances, and infertility. Despite its clinical burden, the molecular mechanisms underlying EM remain elusive, necessitating the discovery of novel biomarkers and therapeutic targets. This study explored the role of colony-stimulating factor 1 receptor (CSF1R) in EM through an integrative approach combining bioinformatics and experimental validation. Differentially expressed genes (DEGs) were identified from the GSE11691 dataset using the limma package. Weighted Gene Co-expression Network Analysis (WGCNA) identified disease-associated gene modules. A Protein-Protein Interaction (PPI) network was constructed, and candidate genes were selected using Least Absolute Shrinkage and Selection Operator (LASSO) and Random Forest algorithms. Expression and function of CSF1R were validated in hEM15A cells via RT-qPCR, Western blotting, CCK-8, EdU, wound healing, and Transwell assays. WGCNA and PPI network analysis revealed a significant enrichment of genes within the PI3K/AKT/mTOR signaling pathway. Cross-validation using LASSO and Random Forest identified THBS2, CSF1R, IL-4R, and FLT1 as potential biomarkers. Among them, CSF1R was found to be significantly overexpressed in endometriotic stromal cells. Knockdown of CSF1R markedly suppressed cell proliferation, migration, and invasion, accompanied by decreased p-AKT expression. Rescue experiments using an AKT activator partially reversed these effects, supporting the functional role of CSF1R in modulating the AKT signaling pathway. CSF1R promotes the progression of endometriosis by modulating AKT signaling. It may serve as a valuable diagnostic biomarker and therapeutic target, providing new insights into endometriosis pathogenesis and treatment strategies. - Source: PubMed
Publication date: 2026/04/14
Ye LanSun JianminLu ChunyanChen ChaoChen QianZhu HaiDing PeifenWu XiaoyanHuang YiZhang Lin - Prior studies in ichthyosis have demonstrated cutaneous and/or systemic immune abnormalities with barrier defects; however, the transcriptomes of the major orphan forms of ichthyosis have yet to be characterized through tape-stripping, a minimally invasive sampling method validated in other inflammatory skin diseases. Skin tape strips from 27 patients with ichthyosis (9 Netherton syndrome/NS, 6 congenital ichthyosiform erythroderma/CIE, 7 lamellar ichthyosis/LI, 5 epidermolytic ichthyosis/EI) and 18 demographically matched healthy controls were analyzed with RNA-seq. Differential expression was defined as fold change>2 and false-discovery rate<0.05. All subtypes shared significant Th17/Th22 upregulation (e.g. S100A7/8/9, PI3, CCL20), and Th2 products (e.g. TNFRSF4, IL13, CCR4) were particularly increased in NS. Tape strips additionally captured common increases in Th1 (IL1B, OASL), and IL4R upregulation in NS, LI, and EI. While modulation of lipid markers was variable across subtypes, several epidermal differentiation complex/cornified envelope (EDC-CE) genes were increased in all or most subtypes. Disease-severity metrics were moderately correlated with increases in ceramide synthase CERS3 and Th17/Th22 and late cornified envelope markers. Changes in immune and EDC-CE tape-strip markers correlated significantly and positively with those measured in biopsies. Our findings highlight tape-stripping as a minimally invasive approach to profile ichthyosis, which could provide future pathogenic and therapeutic insights. - Source: PubMed
Publication date: 2026/04/09
Kim MadelineManson MeredithLiu YingRangel StephanieKaplan NihalRabbaa LydiaChoate KeithBose SwaroopMetukuru RagasrutiLin XinyiLargen JosephShah ManaliEstrada Yeriel DPaller Amy SGuttman-Yassky Emma - The restoration of white matter damage is essential for the functional recovery observed in demyelinating diseases such as multiple sclerosis (MS). Interleukin 4 (IL-4), a type II cytokine, has been acknowledged for its protective role in modulating microglia and immune cells, thus suppressing inflammatory processes. Emerging evidence suggests that IL-4 extends beyond its immunomodulatory function, playing a part in memory, neuronal pruning, protection, and neurodegeneration. Here, our study identified the capacity of IL-4 to stimulate myelinogenesis and remyelination in the central nervous system. We observed dynamic changes in IL-4Rα expression during both developmental myelination and remyelination. Intranasal IL-4 administration during a critical postnatal period significantly enhanced myelination. Following demyelination induced by lysophosphatidylcholine, IL-4 was found to augment remyelination and restore motor function. Using genetic knockout experiments in vitro, we further showed that IL-4 binding to IL-4Rα and activating the PPARγ signaling pathway, thereby upregulating GPNMB, a downstream effector that promotes oligodendrocyte differentiation and myelination. These findings reveal a novel protective role for IL-4 in CNS repair, extending beyond its established functions in microglia, macrophages, or neurons. Intranasal IL-4 delivery may represent a promising therapeutic strategy for enhancing white matter integrity in leukodystrophies and MS. Abbreviations: MS, multiple sclerosis; IL-4, Interleukin 4; CNS, central nervous system; OPCs, oligodendrocytes precursor cells; IL-4R, IL-4 receptor; i.n., intranasal; LPC, lysophosphatidylcholine; PVL, periventricular leukomalacia; EAE, experimental autoimmune encephalomyelitis; dpi, days post immunization; dpl, days post lesion; Nkx2.2, NK2 homeobox 2; Olig2, oligodendrocyte transcription factor 2; OLs, oligodendrocytes; SOX10, SRY-Box Transcription Factor 10; PDGFRα, platelet derived growth factor receptor alpha; CNPase, 2',3'-Cyclic Nucleotide 3' Phosphodiesterase; APC, adenomatous polyposis coli; ASPA, aspartoacylase; GFAP, glial fibrillary acidic protein; Iba1, ionized calcium binding adaptor molecule 1; MBP, myelin basic protein; TEM, transmission electron microscopy; CC, corpus callosum; GCC, genu of the corpus callosum; CG, cingulum; CTX, cortex; STR, striatum; EC, external capsule; Pre-OLs, pre-myelinating oligodendrocytes; STAT6, signal transducer and activator of transcription 6; Pio, pioglitazone; T3, triiodothyronine; CNTF, ciliary neurotrophic factor; PPARγ, peroxisome proliferator-activated receptor γ. - Source: PubMed
Publication date: 2026/04/02
Yin Yu-JingLi Si-HanYu Feng-LinZhang YanDu Ruo-YanLi HuanZou Ya-RouZhang Lin-JieZhang YuanHan Bing - Asthma is a chronic inflammatory respiratory disease characterized by significant heterogeneity, which complicates accurate patient classification and management. With the aim of defining new, reliable biomarkers, we previously evaluated the potential of 94 genes to differentiate allergic asthma (AA) from nonallergic asthma (NA) based on their expression in peripheral blood mononuclear cells (PBMCs). Here, the most promising biomarkers were further analyzed in a 2-year longitudinal cohort of 24 healthy controls (HCs), 18 NA patients, and 51 AA patients. - Source: PubMed
Publication date: 2026/03/26
Cremades-Jimeno LucíaLópez-Ramos MaríaBaos SelenFernández-Santamaría Rubénde Pedro María AMahíllo-Fernández IgnacioRosales-Ariza CristinaOlaguibel José MDel Pozo VictoriaCaballero María LLuna-Porta Juan AQuirce SantiagoBarroso BlancaBetancor DianaValverde-Monge MarcelaSastre JoaquínCárdaba Blanca