Recombinant Human ADAM12 Protein
- Known as:
- Recombinant Human ADAM12 Protein
- Catalog number:
- ad-870
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Proxinobio
- Gene target:
- Recombinant Human ADAM12 Protein
Related genes to: Recombinant Human ADAM12 Protein
- Gene:
- ADAM12 NIH gene
- Name:
- ADAM metallopeptidase domain 12
- Previous symbol:
- -
- Synonyms:
- MCMPMltna, MLTN
- Chromosome:
- 10q26.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-01
- Date modifiied:
- 2016-10-05
Related products to: Recombinant Human ADAM12 Protein
Related articles to: Recombinant Human ADAM12 Protein
- Keloids are fibroproliferative scars that extend beyond the original wound margins and may cause pain, pruritus, and substantial psychosocial distress. Earlobe keloids are common, clinically distinctive lesions with high recurrence rates; however, the molecular mechanisms underlying their development remain incompletely characterized. Existing transcriptomic studies have largely focused on extracellular matrix genes, with limited integration of metabolism-related pathways. - Source: PubMed
Publication date: 2026/07/07
Tafner DanielleNaccarato Andressa MarangoniIsoldi Felipe ContoliFelix Gabriel de Almeida ArrudaNogueira Beatriz Ribeirode Morais Rafael Leite TavaresPesquero João BoscoGragnani Alfredo - Fibrosing skin diseases are highly morbid conditions with diverse clinical and histopathologic features. Prior work, primarily in systemic sclerosis (SSc), has yielded mixed data regarding the immune drivers of fibrosis, as well as the identity and spatial localization of pro-fibrotic fibroblast cell subsets. Here, we focus on morphea and eosinophilic fasciitis (EF), which cause more acutely inflammatory skin fibrosis. Using multimodal single-nucleus and spatial transcriptomics, we find that effector CD8+ T cells are highly enriched in fibrotic skin. These cells are particularly abundant in inflammatory tissue domains bordering fibrotic stroma, which are marked by expression of interferon-γ stimulated genes. Inflammatory domains feature a loss of local homeostatic fibroblast populations and replacement with ADAM12-expressing inflammatory fibroblasts and myofibroblasts, which co-localize closely with CD8+ T cells. All subtypes of morphea featured similar patterns of CD8+ T-cell-associated fibro-inflammatory zonation and fibroblast transformation, suggesting that shared mechanisms can drive fibrosis across stromal compartments of skin. We apply these findings to a large publicly available scleroderma dataset and find that similar processes occur in SSc. Mechanistically, ablation of CD8+ T cells in mice ameliorates bleomycin-driven inflammation and fibrosis, as does fibroblast-intrinsic abrogation of IFN-γ signaling. These data establish CD8+ T cell-driven fibrogenesis as a key feature of fibrosing skin diseases and raise the prospect of targeting CD8+ T cells in autoimmune fibrosis more broadly. - Source: PubMed
Publication date: 2026/06/22
Boothby Ian CGan Thomas CJohri VrindaFlynn EmilyKazmi MahaMaliskova LenkaShaikh SabaYellamilli ShivaramFragiadakis Gabriela KNeuhaus IsaacEckalbar WalterCohen Jarish NCombes Alexis JHaemel AnnaRosenblum Michael DKinet Maxime J - MicroRNAs play key roles in tumor progression. miR-2116-5p is downregulated in lung adenocarcinoma (LUAD), and this study investigated its prognostic value and functional role in the disease. - Source: PubMed
Publication date: 2026/06/26
Huang HanxingXiao LihanXiao MinChen KaiyingChen ShumeiWu Ning - Epithelial cancers such as stomach and ovarian cancer tend to metastasize to the peritoneum, often leading to intractable disease and poor survival. The mechanisms that enable gastric cancer cells to implant, invade, and survive in the peritoneal niche are poorly understood. We developed a novel human peritoneal explant model using freshly harvested peritoneal tissue samples. GFP-labeled human gastric adenocarcinoma cells (AGS) were co-cultured with the peritoneal samples, and 2% of these cells implanted into the peritoneum. The transcriptomic profile of the implanted AGS cells was compared to AGS cells that failed to implant using RNA sequencing. Differentially expressed genes in implanted AGS cells were enriched for cell adhesion and motility. We functionally validated these genes with CRISPR knockout and identified ADAM12 as a regulator of peritoneal metastasis. ADAM12 KO significantly impaired peritoneal metastasis in vivo and ex vivo and marked disruption of the ITGβ1 interactome in GCa cells. Our approach and the new data identify a distinct peritoneal metastasis gene set that facilitates the implantation and invasion of gastric cancer cells within the peritoneum. Disruption of these pathways with peritoneal-directed therapies has the potential to improve survival in patients with high-risk primary gastric cancer. - Source: PubMed
Publication date: 2026/06/23
Ng DeannaKazazian KarinehLee KieraLu Yi QingAli AimanPacholczyk KarinaBrar SavtajConner JamesJurisica IgorMcCulloch Christopher AllanKim Dae-KyumSwallow Carol JaneMagalhaes Marco - Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, with hypoxia contributing to tumor progression and treatment resistance. Identifying hypoxia-related biomarkers could enhance prognosis and therapeutic strategies for LUAD. - Source: PubMed
Publication date: 2026/06/03
Alghamdi BandarRocha Sonia