Chicken Interleukin 9,IL-9 ELISA Kit
- Known as:
- Chicken Interleukin 9,Interleukin-9 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- kn0040ch
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kono Biotech
- Gene target:
- Chicken Interleukin 9 IL-9 ELISA Kit
Related genes to: Chicken Interleukin 9,IL-9 ELISA Kit
- Gene:
- IL9 NIH gene
- Name:
- interleukin 9
- Previous symbol:
- -
- Synonyms:
- IL-9, HP40, P40
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
Related products to: Chicken Interleukin 9,IL-9 ELISA Kit
Related articles to: Chicken Interleukin 9,IL-9 ELISA Kit
- Recent reports indicate that stem cell spheres might offer enhanced therapeutic benefits by promoting cell engraftment ability, stemness, angiogenesis, and chemotaxis. Hence, we investigated whether amniotic fluid stem cells (AFSC) spheres could provide therapeutic benefits in stress urinary incontinence (SUI) due to their urethral sphincter-specific commitment. The isolated human AFSCs were characterized by flow-cytometry-based immunophenotyping and their multidifferentiation potential (osteo-, adipo-, and chondrogenic lineages). Time-dependent (>12, 16∼20, and 48 hours) culture conditions for AFSCsphere formation were optimized. Urodynamic parameters, including leak point pressure (LPP) and intercontraction interval (ICI), were determined. hAFSCsphere with ∼150 m diameter with minimal core necrosis at 16∼20 hours was found optimal for therapeutic application in the pudendal nerve injury-induced SUI rat model. The AFSCs demonstrated mesenchymal stem cell characteristics and multi-differentiation capabilities with retained levels of pluripotency and neural progenitor markers, SOX2 and nestin, respectively. Compared to AFSC, the AFSCsphere group showed superior LPP and ICI in rats; however, with either modest, relatively low, or unchanged levels of myogenic-lineage genes (, myoD, myogenin, and desmin) between them. Bladder and external urethral sphincter histologic architecture were also improved. Notably, AFSCsphere showed the elevated levels of secetome (VEGF, IL-6, IL-8, IL-9, and MIP-1) than AFSC, when compared to control. This could be attributed to non-myogenic pathways, such as paracrine dominance, including anti-inflammatory, angiogenic, or neurotrophic. Conclusively, our study revealed that AFSCsphere may improve urodynamics despite a significant increase in myogenic regulatory factor expression. Therefore, future studies should quantify AFSCsphere-specific properties, like stemness and cell-cell interactions, in reaching enhanced therapeutic outcomes. - Source: PubMed
Publication date: 2026/07/09
Lu Shing-HwaHwang Shiaw-MinDubey Navneet KumarTsai Ming-SongYun Tien-FuLiao Jiunn-Wang - Immuno-metabolic dysregulation contributes to Alzheimer's disease (AD) pathogenesis, yet the peripheral metabolic landscape and its interplay with neuroinflammation remain poorly characterized in treatment-naïve, late-stage patients. This study aimed to delineate plasma metabolic alterations and immuno-metabolic interactions in Chinese first-time outpatients with late-onset AD (CFTO-LOAD). - Source: PubMed
Publication date: 2026/06/23
Wang Pei-JuanYang Xiao-YuJi LeiShi Jia-JiaCai Xiang-MingSun PengLiu He-XuJiang FeiYang Fan - Myasthenia gravis (MG) is a clinically and immunologically heterogeneous autoimmune disease and there is little known about the differential effects of cytokines in disease subgroups. This study aimed to compare serum cytokine profiles across distinct MG subgroups, including early-onset MG (EOMG), late-onset MG (LOMG), muscle-specific kinase antibody-positive MG (MuSK-MG), thymoma-associated MG (TAMG), and healthy controls (HC) in order to distinguish and determine relatively specific targets for the disease subgroups. - Source: PubMed
Publication date: 2026/07/01
Cebi MerveDurmus HacerÇakar ArmanGünver Mehmet GüvenParman YesimDeymeer FezaSaruhan-Direskeneli Güher - Multiple sclerosis (MS) is a chronic autoimmune disorder of CNS with demyelination, neurodegeneration and compartmentalized inflammatory disorder. Excessive T-helper cell (CD4) activation and unregulated cytokine signaling play a key role in its onset and progression. These changes impair communication between peripheral immune cells and CNS resident microglia, astrocytes and oligodendrocytes. This review provides an overview on the contribution of specific subsets of T-helper cells to MS pathology/immunity. Th1 cells release interferon-γ and lymphotoxin, that stimulate activation of myeloid cells/antigen presentation. Activated by IL-23, the Th17 cells produce IL-17A/F that lowers the blood-brain barrier (BBB) integrity, recruit neutrophils and monocytes, and enhance microglial killing. Activation of CD4 T cells leads to activation of B cells via T follicular helper cells which couple these processes through the production of IL-21 and CXCR5. This leads to the development of tissue-like aggregates and intrathecal antibody production. T-cell plasticity adds to epitope spreading as well as chronic inflammation, IL-22, IL-9, IL-1β, IL-6, and TGF-β (these are additional mediators involved in the regulation of effector phenotypes). In MS, the regulation of dendritic cell co-stimulation and of glial activation often does not work. This is due to the lack of control of dendritic-cells co-stimulation and the lack of regulation of glial activation by regulatory pathways such as FOXP3 regulatory T cells and Tr1 cells that secrete IL-10 and TGF-Beta. The review also explores the cytokine network biomarkers, CSF and serum signatures and single-cell immune states, as well as existing and new drugs. These include migration blockade, targeting of S1P-receptors, anti-CD20 therapy, targeting of Th17/GM-CSF and JAK-STAT pathways, low-dose IL-2, approaches of targeting antigens and engineered Tregs. Investigating the areas of stage and compartment-specific CD4 T-cell circuits can help to advance targeted immunomodulation in progressive MS and neuro-repair. - Source: PubMed
Publication date: 2026/06/25
Egba Simeon IkechukwuIkechukwu Gavin ChibunduOkereke Chinenye IheanyiOrhonigbe Innocent OgheneovoUroko Robert IkechukwuUgwu Okechukwu Paul Chima - Breast cancer (BC) is the most common malignant neoplasm in women worldwide and in Peru. Beyond hormonal and genetic factors, cytokines play a key role in tumor aggressiveness and therapeutic resistance. However, evidence on circulating cytokine profiles in Latin American populations is limited. - Source: PubMed
Publication date: 2026/06/09
Vela-Ruiz Jose MMorante ZaidaFerreyra YomaliGalvez-Villanueva Marco AValencia FernandoCampos-Tineo J JhaninaCallapiña De Paz MarianaCórdova-Salazar Ariana AlessandraMarcos-Carbajal PoolMoreno Lujan Joan MPantoja Lazaro Andy REscobar Caipo Laura GFlores Trujillo Gustavo ACusma Quintana Teresa NDe La Cruz-Vargas Jhony AGomez Henry LSoto Alonso