human β defensin 1, HBD1 ELISA kit
- Known as:
- H. sapiens β defensin 1, HBD1 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- kn0019hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kono Biotech
- Gene target:
- human β defensin 1 HBD1 ELISA kit
Related genes to: human β defensin 1, HBD1 ELISA kit
- Gene:
- DEFB1 NIH gene
- Name:
- defensin beta 1
- Previous symbol:
- -
- Synonyms:
- HBD-1, DEFB-1, DEFB101, HBD1, BD1, MGC51822
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-05-29
- Date modifiied:
- 2015-11-18
Related products to: human β defensin 1, HBD1 ELISA kit
Related articles to: human β defensin 1, HBD1 ELISA kit
- Chronic hepatitis C virus (HCV) infection is associated with prolonged immune activation and systemic inflammation, which may be reflected in circulating immune mediators. Defensins and cytokines have emerged as potential biomarkers for monitoring immune dysregulation in chronic viral hepatitis. This study aimed to monitoring serum levels of human α-defensin-1 (HAD-1) and human β-defensin-1 (HBD-1) with selected cytokines (IL-6, IL-28, TNF-α, and IFN-) in Iraqi patients with chronic HCV and to evaluate their diagnostic performance by the receiver operating characteristic (ROC) analysis. This cross-sectional case-control study was conducted in Iraq during February-November 2025. It included 100 laboratory-confirmed chronic HCV patients and 50 normal controls. Serum HAD-1, HBD-1, IL-6, IL-28, TNF-α, and IFN- were measured by ELISA. Hematological indices and liver function markers were also analyzed. HCV patients showed significantly increased HAD-1 and HBD-1 levels compared with controls (p< 0.01). Cytokine profiling revealed markedly elevated IL-6, IL-28, TNF-α, and IFN- levels in patients, indicating strong activation of inflammatory and antiviral immune pathways (p<0.01). ROC curve analysis demonstrated excellent diagnostic performance of defensins and cytokines to distinguish chronic HCV patients from controls, with area under the curve values ranging from 0.849 to 0.950 units. In conclusion, the circulation of defensins and inflammatory cytokines is markedly up-regulated in chronic HCV and has high diagnostic utility indicating their potential as immune biomarkers for chronic HCV-related inflammation and immune dysregulation. - Source: PubMed
Enad Ahmed TJassim Al-Zahraa JAlwandawi Thuraya KAbbas Ruqaya K - IntroductionThis study aimed to develop a prognostic model based on pain-related PANoptosis genes to enhance therapeutic decision-making for oral squamous cell carcinoma (OSCC) patients.MethodsRNA sequencing data from 323 OSCC patients and 43 controls in the TCGA cohort were analyzed to identify differentially expressed genes (DEGs). Correlation analysis revealed pain-related PANoptosis genes, and a prognostic model was developed using Cox and LASSO regression and validated in the GSE42743 cohort. Immune microenvironment differences were assessed, and drug sensitivity was predicted. qRT-PCR was employed to validate gene expression alterations in OSCC tissues.ResultsAmong 2,253 DEGs, 38 overlapped with PANoptosis-related genes, leading to the identification of 37 pain-related PANoptosis genes that characterized two OSCC subtypes. A Pain-Related PANoptosis-gene model (including CA9, DEFB1, DES, IGLL5, LCE3D, LYNX1, SPINK7) achieved AUCs of 0.626 and 0.690 in the TCGA and validation cohorts, respectively. Significant immune microenvironment differences were noted, with high-risk patients showing immune characteristics associated with a more immunosuppressive environment. GSEA identified activated pathways like autophagy and chemokine signaling in high-risk patients.ConclusionsThe pain-related PANoptosis-gene model effectively stratifies OSCC patients by risk. Sepantronium bromide may represent a potential therapeutic candidate for high-risk patients; however, further experimental validation is required. - Source: PubMed
Publication date: 2026/07/20
Yao YingLiu QiChen SiluWang YanGao Xiang - Colorectal cancer (CRC) develops within a mucosal ecosystem where the microbiota, epithelial barrier, and group 3 innate lymphoid cells (ILC3) jointly shape immune tone. ILC3 plasticity spans both tissue-protective and inflammatory states, and MHC II-dependent antigen presentation-like activity of ILC3 is associated with microbiota-directed CD4 T cell and IgA responses. In CRC, chronic inflammation and dysbiosis drive a shift toward barrier-damaging ILC3 programs, attenuate epithelial antimicrobial defenses, and defocus microbiota-directed immunity. These alterations correlate with more aggressive tumor behavior and poorer responses to immune checkpoint therapy. We integrate this evidence into a feed-forward model in which impaired crosstalk among ILC3, the epithelium, and the microbiota promotes barrier weakening, inflammatory amplification, and tumor progression. Within this framework, we propose biomarker panels that capture ILC3 state, barrier integrity, and DEFB1 expression, together with therapeutic strategies targeting cytokine pathways, metabolism, microbiota structure, and immune checkpoints. - Source: PubMed
Publication date: 2026/06/09
Qiao LuZhang JingwenLi JiaxiLi XiaHe XiaoxiaZhang MingyuLu JingkunZhang XuanDong JingTao GesiWang YueCui JiaxianBao LiliZhao Pengwei - Cryptosporidiosis, caused by the protozoan parasite Cryptosporidium, is a leading cause of severe diarrhea, morbidity, and mortality in immunocompromised patients and malnourished children. Because the only FDA-approved treatment, nitazoxanide, shows limited efficacy in malnourished children and is ineffective in the immunodeficient, novel therapeutics for vulnerable populations are urgently needed. Host-directed therapy (HDT) is a promising strategy that utilizes the induction of endogenous protective molecules. For example, intestinal epithelial cells defend the mucosa by upregulating antimicrobial peptides like β-defensins (DEFBs). Previous work has demonstrated that human DEFB1 possesses anti-cryptosporidial activity. In this work we used synthetic DEFB1-mRNA to induce DEFB1 protein in human intestinal cells and evaluate its protection against Cryptosporidium parvum infection in vitro. - Source: PubMed
Publication date: 2026/06/12
Ortega-Méndez JustineRojas Jose MWhite A ClintonCastellanos-González Alejandro - This study aimed to explore hub circadian rhythm-related genes (CRRGs) associated with sepsis-associated acute kidney injury (saAKI) using machine learning algorithms to provide novel ideas for the diagnosis and treatment of this disease. - Source: PubMed
Publication date: 2026/06/11
Luo YuzhenLiu TangjuanChen Yiqiang