ESRRG 293T Cell Transient Overexpression Lysate(Denatured)
- Known as:
- ESRRG 293T Cell Transient Overexpression Lysate(Denatured)
- Catalog number:
- H00002104-T01
- Product Quantity:
- 100 uL
- Category:
- -
- Supplier:
- Abno
- Gene target:
- ESRRG 293T Cell Transient Overexpression Lysate(Denatured)
Related genes to: ESRRG 293T Cell Transient Overexpression Lysate(Denatured)
- Gene:
- ESRRG NIH gene
- Name:
- estrogen related receptor gamma
- Previous symbol:
- -
- Synonyms:
- NR3B3, ERRg, ERR-gamma
- Chromosome:
- 1q41
- Locus Type:
- gene with protein product
- Date approved:
- 1998-02-17
- Date modifiied:
- 2018-02-14
Related products to: ESRRG 293T Cell Transient Overexpression Lysate(Denatured)
Related articles to: ESRRG 293T Cell Transient Overexpression Lysate(Denatured)
- The estrogen-related receptor (ERR) family, comprising ESRRA (estrogen-related receptor alpha), ESRRB (estrogen-related receptor beta), and ESRRG (estrogen-related receptor gamma), plays a crucial role in regulating metabolic and developmental processes. However, the functional significance of ERRs during preimplantation embryo development remains largely unclear. In the present study, we aimed to systematically characterized ERRs expression dynamics in mouse preimplantation embryo development and elucidated the mechanistic involvement of ERRs in blastocyst formation. Our findings demonstrate that among the estrogen-related receptor family, ESRRG is uniquely and highly expressed at the 2-cell embryo stage and is essential for blastocyst formation. Knockdown of Esrrg significantly reduced global transcriptional activity in the 2-cell embryos, thereby impairing zygotic genome activation (ZGA) and disrupting the 2-cell to 4-cell embryo transition. Given the crucial role of ESRRG in ZGA, the mechanisms governing its own transcriptional regulation are of paramount interest. To this end, we searched for upstream regulators and identified trichorhinophalangeal syndrome I (TRPS1) as a key transcription factor that directly binds to the Esrrg promoter to modulate its expression. Furthermore, the TRPS1-ESRRG regulatory axis orchestrates mouse preimplantation development by controlling the expression of critical ZGA factors, such as Sp1 transcription factor and tankyrase 2. These results establish the TRPS1-ESRRG axis as a critical regulator of mouse preimplantation development through its essential role in modulating zygotic genome activation. - Source: PubMed
Publication date: 2026/06/04
Sun JiandongLiao ShuminLin ZihangLian XiuliXu WeiweiLiu YueWang XuanyiLin ZeyuZhang DiniWang Shie - 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key placental steroidogenic enzyme that converts estrone to estradiol. Prior studies have suggested that reduced placental or circulating HSD17B1 is associated with preeclampsia (PE), but its position within the broader transcriptomic landscape and its relationship to immune changes remain incompletely characterized. - Source: PubMed
Publication date: 2026/05/29
Ling KengHong MinpingJin LiqinLing AiWang Jianguo - Early pregnancy is a highly coordinated process requiring precise embryo-maternal communication. Estradiol-17β (E2) is considered the primary conceptus-derived signal responsible for the maternal recognition of pregnancy in pigs. Successful pregnancy establishment requires two distinct peaks of E2 secretion by porcine conceptuses: during days 11-12 (the maternal recognition of pregnancy) and days 15-30 (implantation). Although the role of E2 in signaling to the maternal system is well established, its potential autocrine effects on conceptus development remain unclear. This study examined whether E2 regulates trophoblast function during the maternal recognition of pregnancy and implantation. We demonstrated that expression of estrogen receptors (ESR1, ESR2, GPER1) and selected pregnancy-related genes (FOXO3, GDF15, SERPINE1, ESRRB, ESRRG) changes during early pregnancy in the pig. E2 regulated the gene expression of its receptors (ESR1, ESR2, GPER1), genes involved in E2 synthesis (HSD17B1), prostaglandin synthesis (PTGS2, AKR1C4, PTGES), and key mediators of pregnancy establishment (IL1B2, SERPINE1, FOXO3, GDF15, ESRRB and ESRRG). Furthermore, E2, acting via nuclear estrogen receptors, enhanced trophoblast cell proliferation on days 12 and 15 of pregnancy, and increased adhesion as well as MAPK1/3 and PTK2 protein phosphorylation on day 15 of pregnancy. E2 stimulated cell proliferation via MAPK and PI3K/AKT/mTOR pathways, whereas E2-promoted adhesion was mediated via MAPK and PI3K/AKT signaling. Concluding, these findings indicate that E2 functions not only as a critical embryonic signal for the maternal recognition of pregnancy but also plays an autocrine role in conceptus development, regulating gene expression and trophoblast cell function during early gestation in pigs. - Source: PubMed
Publication date: 2026/04/11
Goryszewska-Szczurek EwelinaWaclawik Agnieszka - Hepcidin (encoded by the HAMP gene), produced primarily by hepatocytes, is the master regulator of systemic iron homeostasis. Its dysregulation contributes to various iron-related metabolic disorders. Cereblon (CRBN) has been implicated in metabolic regulation, while estrogen-related receptor gamma (ESRRG) is known to govern energy homeostasis and mitochondrial function. In this study, we demonstrate a novel CRBN-ESRRG signaling pathway that mediates endoplasmic reticulum (ER) stress-induced hepatic HAMP expression. In mice and primary hepatocytes exposed to tunicamycininduced ER stress, gene expression and biochemical analyses revealed significant increases in the transcript levels of hepatic Crbn, Esrrg, and Hamp. Correspondingly, hepcidin protein levels were elevated, accompanied by reduced serum iron levels and increased cellular iron levels, consistent with hepcidinmediated regulation of iron distribution. Overexpression of Crbn enhanced ESRRG expression and increased hepatic hepcidin production, while knockdown of either Crbn or Esrrg attenuated this response. Chromatin immunoprecipitation assays demonstrated enhanced recruitment of ESRRG to the Hamp promoter. Collectively, these findings identify a CRBN-ESRRG regulatory axis that drives hepatic HAMP expression under ER stress and suggest a potential therapeutic target for ER stress-associated metabolic and iron disorders. [BMB Reports 2026; 59(5): 291-298]. - Source: PubMed
An SeungwonKang Chung HyoPark TaehyunNedumaran NedumaranSung YounjooChung TaehoonPark Chul-SeungDjalilian Ali RKim Yong Deuk - Alternative splicing plays a critical role in cardiac development and function and becomes dysregulated in heart failure. Although splicing defects have been described in both dilated (DCM) and ischaemic (ICM) cardiomyopathy, the extent to which these alterations contribute to disease mechanisms and how they are spatially distributed across cardiac regions remains poorly understood. This study aimed to profile alternative splicing events across the left ventricle (LV), right ventricle (RV), and interventricular septum (IVS) in end-stage heart failure patients with DCM and ICM, and to investigate potential regulatory factors driving these changes. - Source: PubMed
Furtado MartaBarbosa PedroWemans AnaZhang LuLumley AndrewCarvalho TeresaNapoleão PatríciaLeszek PrzemyslawCarmo-Fonseca MariaDevaux YvanMartins Sandra