5-min. Genomic DNA Prep for PCR
- Known as:
- 5-min. Genomic Desoxyribonucleic acid Prep PCR test kit
- Catalog number:
- p930-100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- 101bio
- Gene target:
- 5-min. Genomic DNA Prep for PCR
Related genes to: 5-min. Genomic DNA Prep for PCR
- Gene:
- PREP NIH gene
- Name:
- prolyl endopeptidase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 1996-03-12
- Date modifiied:
- 2016-10-05
Related products to: 5-min. Genomic DNA Prep for PCR
Related articles to: 5-min. Genomic DNA Prep for PCR
- Pre-exposure prophylaxis (PrEP) is an antiretroviral medication used to prevent human immunodeficiency virus (HIV) infection. Owing to the high incidence and prevalence of HIV Infection among women compared to men, PrEP has the potential to reduce the rate of HIV infection among women in sub-Saharan Africa, including Tanzania. This study aimed to assess women's knowledge of and attitudes toward PrEP and its associated factors as an effective strategy for HIV prevention, using nationwide data. This study utilized data from the 2022 Tanzania demographic and health survey conducted between February and July 2022, the stratified sampling, by geographic region and urban/rural areas, employed a 2-stage process: primary sampling units from census areas, then households via probability systematic sampling. STATA 18.5 was used for data management and analysis, including descriptive statistics and weighted logistic regression to identify factors associated with PrEP knowledge and attitudes. Odds ratios (OR) and 95% confidence intervals (CIs) were used to estimate the strength of association. A total of 15,254 women with a mean age of 29.3 years (standard deviation = 9.8) were included in the study. The study found that 5.6% of women had knowledge of and positive attitudes towards HIV PrEP. In the adjusted analysis, those aged 35 to 49 years (adjusted odds ratio [AOR] = 2.09, 95% CI = 1.52-2.88), women with media exposure (AOR = 1.30, 95% CI = 1.24-1.83), women who had visited a health facility in the past 12 months (AOR = 1.44, 95% CI = 1.18-1.75), women who had ever heard of sexually transmitted infections (AOR = 1.51, 95% CI = 1.11-2.04), and those who had ever been tested for HIV (AOR = 1.48, 95% CI = 1.02-2.15) were significantly associated with knowledge and attitude towards HIV PrEP among women of reproductive age in Tanzania. This study found low knowledge of and attitude toward PrEP, highlighting the importance of PrEP education in women of reproductive age. However, strengthening PrEP education in health facilities' service entry points, expanding educational initiatives through strategic community outreach programs, and media engagement represent transformative approaches to improving knowledge and attitude. - Source: PubMed
Mwanahapa PatrickEliufoo Stephano ElihurumaMugula AidatMtoro Mtoro J - The remarkable success of biomedical HIV prevention has transformed the global response to HIV through the widespread implementation of oral pre-exposure prophylaxis (PrEP), long-acting antiretroviral agents and HIV self-testing. However, ensuring equitable access to these interventions remains a major challenge. Although more than one billion people worldwide live with a disability, disability has received surprisingly little attention within contemporary HIV prevention research and implementation. This narrative review examines the intersection between disability and modern HIV prevention, integrating evidence on sexual and reproductive health, structural barriers to healthcare and the evolving landscape of biomedical prevention. The available literature suggests that people with disabilities experience persistent inequalities in access to sexuality education, HIV information, testing and preventive services, largely due to physical, communication and systemic barriers rather than biological vulnerability. Despite these well-documented disparities, disability is rarely incorporated into PrEP implementation studies, HIV prevention policies or differentiated service delivery models. We argue that disability should be considered an implementation and health equity challenge rather than a pharmacological one. The effectiveness of biomedical prevention ultimately depends on healthcare systems capable of delivering accessible, person-centred and inclusive services. Integrating disability into implementation science, clinical practice and public health policy represents an essential step toward achieving equitable HIV prevention. As HIV prevention continues to evolve, accessibility should be recognised not as an optional adaptation but as a fundamental component of high-quality prevention programmes. - Source: PubMed
Publication date: 2026/09/14
De Maria FrancescoFusco PaoloRusso Alessandro - : Multipurpose prevention technologies (MPTs) that combine protection against HIV and unintended pregnancy can improve women's health outcomes by simplifying use and enhancing adherence. We developed a long-acting (LA) implant for the simultaneous and sustained delivery of the antiretroviral islatravir (ISL) and the contraceptive hormone etonogestrel (ENG). : Using extruded poly-ε-caprolactone (PCL) tubing, reservoir-style implants were fabricated and evaluated in three configurations: (Group 1) a two-segment implant formed by joining separate ISL- and ENG-containing tubes; (Group 2) a single tube divided into two drug compartments by a heat-sealed PCL spacer; (Group 3) separate single-drug implants. In vitro release was assessed in phosphate-buffered saline at 37 °C, and safety and pharmacokinetic (PK) profiles were evaluated in New Zealand White rabbits (n = 4/group) over approximately 90 days. : The average ISL daily in vitro release rates for Groups 1, 2, and 3 were 29 ± 5 µg/day, 18 ± 5 µg/day, and 47 ± 8 µg/day, respectively, and ENG daily in vitro release rates were 39 ± 9 µg/day, 41 ± 8 µg/day, and 33 ± 7 µg/day. From day 28 through the end of the study, median (IQR) plasma concentrations were 0.22 (0.18-0.27) ng/mL, 0.28 (0.24-0.33) ng/mL, and 0.31 (0.28-0.33) ng/mL for ISL in Groups 1, 2, and 3, respectively, and 0.26 (0.21-0.31) ng/mL, 0.25 (0.16-0.47) ng/mL, and 0.30 (0.23-0.38) ng/mL for ENG in Groups 1, 2 and 3, respectively. Implants across all groups were well tolerated and demonstrated favorable local tolerability over the 90-day dosing period. : Integration of multiple indications into a single platform capable of sustained release over an extended duration holds potential to address persistent gaps in women's sexual and reproductive health needs. - Source: PubMed
Publication date: 2026/08/26
Krovi ArchanaLevin LeannaGatto Greg JLuecke Ellen HBrand RhondaSwistok AmandaCottrell Mackenzie LSchauer Amanda PJohnson Leah M - Scan-assisted interocclusal registration may vary with record extent and occlusal support. Using separately fabricated high-hardness vinyl polysiloxane (VPS) records, a fixed bilateral buccal intraoral scanner (IOS) acquisition protocol, optical reference articulations, and position-level three-dimensional analysis, this in vitro study compared prepared-tooth (Hard-Prep) and complete-arch (Hard-Arch) records across three support configurations and assessed a no-record IOS workflow. Ninety VPS-based and 45 no-record IOS acquisitions were analyzed. VPS records were fabricated under a 3.0 kg load; measurements used a 1.0 kg load. Overall three-dimensional deviation (dXYZ) was averaged over five mandibular positions. Log-transformed dXYZ was analyzed by ordinary least squares with Holm-adjusted contrasts. The Hard-Arch/Hard-Prep contrast was not statistically significant under bilateral extended support. Hard-Arch showed higher dXYZ under unilateral extended support (ratio, 1.75; 95% confidence interval (CI), 1.54-1.99; < 0.001) and unilateral limited support (ratio, 1.58; 95% CI, 1.39-1.80; < 0.001). In the no-record workflow, unilateral extended support exceeded bilateral extended support (ratio, 1.50; 95% CI, 1.31-1.72; < 0.001), whereas unilateral limited support was lower than unilateral extended support (ratio, 0.68; 95% CI, 0.59-0.77; < 0.001). Prepared-tooth records yielded lower deviation in both unilateral configurations, while the no-record workflow varied with support configuration. - Source: PubMed
Publication date: 2026/08/25
Matta Ragai EdwardTöpel PaulaLotz FabianWichmann ManfredRies Johannes Matthias - Rabies remains a life-threatening disease affecting children in endemic regions including Thailand. The cost-effectiveness of pre-exposure prophylaxis (PrEP) rabies vaccination in the Thai context is unclear. This study analysed the cost-utility of adding PrEP rabies vaccination to post-exposure prophylaxis (PEP) rabies vaccination compared with PEP alone in 5-year-old children. - Source: PubMed
Publication date: 2026/09/25
Soopairin SutineeLuksameesate ParnnaphatArthonchaikul NattiyaPunrin SudaTantawichien TerapongTaychakhoonavudh Suthira