LBX2 (Human) Recombinant Protein (P01)
- Known as:
- LBX2 (Human) Recombinant Protein (P01)
- Catalog number:
- H00085474-P01-25
- Product Quantity:
- 25 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- LBX2 (Human) Recombinant Protein (P01)
Related genes to: LBX2 (Human) Recombinant Protein (P01)
- Gene:
- BZW2 NIH gene
- Name:
- basic leucine zipper and W2 domains 2
- Previous symbol:
- -
- Synonyms:
- HSPC028, MST017, MSTP017
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-05
- Date modifiied:
- 2016-10-05
- Gene:
- C2CD3 NIH gene
- Name:
- C2 calcium dependent domain containing 3
- Previous symbol:
- -
- Synonyms:
- DKFZP586P0123
- Chromosome:
- 11q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2016-06-08
- Gene:
- LBX2 NIH gene
- Name:
- ladybird homeobox 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-26
- Date modifiied:
- 2015-08-25
- Gene:
- MBTD1 NIH gene
- Name:
- mbt domain containing 1
- Previous symbol:
- -
- Synonyms:
- SA49P01, FLJ20055
- Chromosome:
- 17q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-15
- Date modifiied:
- 2015-04-21
- Gene:
- TMEM63C NIH gene
- Name:
- transmembrane protein 63C
- Previous symbol:
- C14orf171
- Synonyms:
- DKFZp434P0111, CSC1, hsCSC1
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-10
- Date modifiied:
- 2017-10-17
Related products to: LBX2 (Human) Recombinant Protein (P01)
Related articles to: LBX2 (Human) Recombinant Protein (P01)
- Recent studies have identified various roles for long non-coding RNAs (lncRNAs) in cancer progression. However, an in-depth understanding of the regulatory mechanisms of lncRNAs in colorectal cancer (CRC) and their diagnostic significance is rather limited. - Source: PubMed
Publication date: 2025/12/12
Wang JuanLi ChaoWu GuanghaiXu Jing - Colorectal cancer (CRC) ranks as a leading cause of cancer-related mortality worldwide, yet its molecular mechanisms remain incompletely understood. The transcription factor LBX2 regulates morphogenesis of multiple organ systems in vertebrates, yet its role in CRC progression remains poorly understood. In the study, we found that LBX2 knockdown suppresses CRC proliferation in vitro and in vivo. ChIP-seq/RNA-seq identifies GFPT2 as a direct transcriptional target of LBX2. The LBX2/GFPT2 axis elevates UDP-GlcNAc levels and O-GlcNAcylation, promoting Raptor T700 glycosylation. This modification enhances mTORC1 activation by strengthening Raptor-Rag interactions, accelerating glycolysis and lactate production. Accumulated lactate induces histone H4K12 lactylation, which further upregulates LBX2 transcription, forming a positive feedback loop. Clinically, high LBX2 expression correlates with elevated PET-CT SUVmax values (indicating hyperglycolysis) in CRC patients. Patient-derived organoids with high LBX2 show increased sensitivity to the GLUT1 inhibitor. LBX2 thus serves as both a metabolic driver and a potential biomarker for CRC-targeted therapies. - Source: PubMed
Publication date: 2025/12/12
Jiang YiwenWang LudeChen LinShen KaiChang JieZheng ShicongChen ZeweiGe ChenyangYu MinYu ShianLin Haiping - Radioresistance is a significant factor affecting the therapeutic efficacy of radiotherapy. This study is aimed at investigating the molecular mechanism by which LBX2-AS1 regulates pyruvate kinase M2 (PKM2) to influence radioresistance and its potential as a biomarker for radioresistance in esophageal cancer. - Source: PubMed
Publication date: 2025/11/13
Zhang FuhuiWang ZhiwuYao XueminZhang Qingyu - Periodontitis poses challenges in both early detection and late-stage treatment. The purpose of this study was to understand the role and mechanism of the lncRNA LBX2-AS1 in periodontitis. - Source: PubMed
Publication date: 2025/09/29
Liu FangQian ChengWang WenruiZhang RongxiuXu LiLiu Liang - Epilepsy is a long-lasting neurological condition distinguished by recurring seizures, and related to oxidative stress and inflammation. This study investigates the effects of long non-coding RNA LBX2-AS1 on childhood epilepsy. - Source: PubMed
Publication date: 2025/06/15
Li QianLi Ning