IL-7, Human Protein
- Known as:
- Interleukin-7, Human Protein
- Catalog number:
- z02704-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- IL-7 Human Protein
Related genes to: IL-7, Human Protein
- Gene:
- IL7 NIH gene
- Name:
- interleukin 7
- Previous symbol:
- -
- Synonyms:
- IL-7
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-10-12
- Date modifiied:
- 2016-10-11
- Gene:
- IL7R NIH gene
- Name:
- interleukin 7 receptor
- Previous symbol:
- -
- Synonyms:
- CD127, IL7RA
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2019-04-23
Related products to: IL-7, Human Protein
Related articles to: IL-7, Human Protein
- This article focuses on Sepsis-related immunosuppression, systematically expounding on its pathological mechanisms, monitoring methods, and treatment strategies. Immunosuppression in sepsis involves multi-level functional exhaustion of the innate and adaptive immune systems, such as dysfunctions of monocytes/macrophages, neutrophils, and dendritic cells, depletion of T and B cells, and imbalance of the cytokine network. The monitoring of the immune state mainly relies on the detection of the quantity and function of immune cells, HLA-DR expression, and cytokine levels. Treatment methods include immunostimulation (such as IL-7, GM-CSF), immune checkpoint inhibitors, other immunomodulatory therapies (such as IFN-γ, mesenchymal stem cells), and intravenous immunoglobulin. However, the clinical transformation effects of existing treatment strategies remain to be verified. In-depth research on sepsis-related immunosuppression is of great significance for improving clinical diagnosis and treatment and reducing mortality.Importantly, the pathogenesis and trajectory of immunosuppression in children differ significantly from adults due to age‑specific immune development, necessitating a separate discussion of pediatric‑specific mechanisms and monitoring strategies. - Source: PubMed
Publication date: 2026/07/24
Ren ShuaiWen Jun - Historically, effective vaccination has saved millions of lives and made an enormous contribution to addressing global public health threats. However, aging is an inevitable factor that negatively affects vaccine effectiveness and efficacy. With age, humans develop dysregulation of innate immune pathways, increased levels of proinflammatory markers, thymic involution, declines in T- and B-cell numbers and function, dysregulated metabolism, and epigenetic alterations. Immunosenescence, the gradual deterioration of host immunity with age, plays a critical role in susceptibility to infection, disease progression, and vaccine efficacy. Immunosenescence is often accompanied by inflammaging, an age-related increase in proinflammatory cytokine and chemokine levels. This multifactorial and dynamic process can lead to poor vaccine responses, potentially resulting in higher morbidity and mortality in older adults. Therefore, research focused on understanding the impact of immunosenescence and inflammaging on vaccine response will undoubtedly help optimize vaccine delivery among elderly individuals. In this review, we summarize the most recent knowledge on the multifactorial effects of age-induced immunosenescence and inflammaging and their role in vaccine efficacy against respiratory tract infections. The review further discusses strategic approaches such as IL-7 therapy, senolytic therapy, increasing telomerase activity, use of mTOR inhibitors, B cell therapy, development of broader vaccines and new adjuvants, and positive lifestyle changes, to enhance vaccine immunogenicity and efficacy in older adults. This could provide theoretical insights to improve vaccine effectiveness in the elderly and help address major global health issues. - Source: PubMed
Publication date: 2026/07/03
Albaloshi JalnarAlnakhli AlhussainCham Lamin B - During pregnancy, exposure to maternal HIV and a disrupted cytokine environment may impact foetal immune development and health outcomes through cytokine-mediated mechanisms. We evaluated (i) peripheral blood cytokine differences in pregnant women with and without HIV, (ii) longitudinal trajectories in HIV-exposed uninfected (HEU) and HIV-unexposed uninfected (HUU) children, and (iii) cytokine groupings. Additionally, we explored the impact of the timing of maternal antiretroviral treatment (ART) initiation on cytokine levels and if cytokines predicted repeated hospitalisations during the first two years of life. - Source: PubMed
Publication date: 2026/07/22
Kangwa Tusekile SWedderburn Catherine JAnnandale Jenna FDonald Kirsten ALittle FrancescaZar Heather JStein Dan JNaudé Petrus J W - Influenza virus remains a major global public health threat due to its high transmissibility, ability to cause severe disease, and pandemic potential. Although vaccination is the main strategy for reducing the burden of influenza, it has notable limitations. Therefore, novel therapeutic and immunomodulatory approaches are urgently needed. Here, using plasmid-driven reverse genetics, we engineered a defective recombinant influenza virus encoding interleukin 7 (Flu:IL-7), to investigate the role of IL-7 in influenza pathogenesis and immunomodulation in a murine model. Our findings demonstrate that Flu:IL-7 is safe and effectively attenuates disease severity caused by a wild-type replicative influenza virus (PR8), improving clinical recovery and reducing disease-associated morbidity. Notably, local expression of IL-7 through the Flu:IL-7 vector at the time of PR8 infection significantly reduced the severity of secondary pneumococcal pneumonia. These protective effects were associated with earlier and more coordinated pulmonary immune response, characterized by enhanced activation and expansion of innate and adaptive immune cells, early formation of iBALT-like aggregates, and reduced tissue damage. Collectively, our findings suggest that transient local IL-7 expression temporally reprograms the pulmonary immune response, promoting early antiviral immunity followed by timely resolution of inflammation. In summary, Flu:IL-7 provides a useful experimental model for investigating the immunomodulatory role of IL-7 during influenza infection. Our findings support transient local IL-7 expression as a promising host-directed strategy to improve disease outcome and reduce influenza-associated complications. These concepts may also be applicable to other diseases in which modulation of the local immune response is desirable, including lung cancer and COVID-19. - Source: PubMed
Publication date: 2026/07/21
Messias Sarah Giarola da Silvade Paula Ianca Évelin SilvaCardoso Kimberly FreitasGarcia Cristiana Coutode Mendonça Ângelo Ana Luiza Pessoade Faria Gonçalves Ana PaulaMelo Eliza MathiasTavares Luciana PáduaFaustino Lídia PaulaAlves Pedro AugustoDos Reis Jordana Grazziela Alves CoelhoCarvalho Andréa TeixeiraRibeirodo Valle Antonelli LisXavier Marcelo Antônio PascoalFilho Olindo Assis MartinsMachado Alexandre de Magalhães VieiraAraújo Márcio Sobreira Silva - To characterize the cellular and molecular composition of the scleral lens (SL) fluid reservoir (FR) in keratoconus and determine whether this compartment reflects disease-specific inflammation. - Source: PubMed
Publication date: 2026/07/17
Keyzer MatthewGuerra ElissaBhattacharyya PradiptaWalker Maria K