IL-16, Human Protein
- Known as:
- Interleukin-16, Human Protein
- Catalog number:
- z02196-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- IL-16 Human Protein
Related genes to: IL-16, Human Protein
- Gene:
- IL16 NIH gene
- Name:
- interleukin 16
- Previous symbol:
- -
- Synonyms:
- LCF, IL-16, prIL-16, HsT19289, FLJ42735, FLJ16806
- Chromosome:
- 15q25.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: IL-16, Human Protein
Related articles to: IL-16, Human Protein
- Global freshwater salinization endangers aquatic species, yet its impacts on crustaceans remain poorly understood. This study investigated the hepatopancreatic response of to carbonate alkalinity stress (0, 4.375, 8.75, 17.5, and 35 mmol/L) over 24, 48, and 96 h, integrating histology, ultrastructure, gene expression (RT-qPCR), and non-specific immune enzyme assays. Histopathological and ultrastructural analyses revealed concentration- and time-dependent damage, including vacuolization, hepatic tubule disintegration, nuclear condensation, mitochondrial reduction, and loss of cellular integrity. Molecular analysis demonstrated upregulation of genes associated with the TLR2-MyD88-NF-κB pathway and inflammatory genes (, ), alongside increased expression, confirming severe inflammation and cellular stress. Furthermore, apoptosis was induced via upregulated and , downregulated , and DNA fragmentation. Non-specific immune responses in the hepatopancreas exhibited dynamic changes: acid phosphatase (ACP) was initially activated at low alkalinity but inhibited at high concentrations, while alkaline phosphatase (AKP) activity increased at 96 h. Notably, the hepatopancreas proved more sensitive to this stress than the hemolymph. Collectively, carbonate alkalinity causes multidimensional hepatopancreatic injury in through structural disruption, inflammation mediated by TLR2-MyD88-NF-κB signaling pathway-related genes, apoptosis induction, and immune enzyme dysregulation, posing a significant threat to crab health in salinized waters. - Source: PubMed
Publication date: 2026/06/23
Bai YichenGuan HongkunYang YuhongSheng HaoyangJiang ZhilinLiu KangrunFu ChangruiLiu PengYang Chenghui - Stratification of therapeutic responses may help identify efficacious therapies for osteoarthritis (OA). In the PROMOTE randomised trial, participants with elevated baseline high-sensitivity C-reactive protein (hs-CRP) showed greater pain reduction after methotrexate treatment. We set out to interrogate a broader panel of serum/plasma inflammatory response markers relevant to methotrexate actions as potential biomarkers of therapeutic effect. Our objectives were to: (i) characterize changes in these systemic markers during methotrexate treatment; determine whether (ii) baseline levels or (iii) changes in any marker during treatment were associated with treatment response; and (iv) compare these findings with the more established clinical inflammatory marker, hs-CRP. - Source: PubMed
Publication date: 2026/07/07
Liang JiahaoPapadaki ArtemisAlderson JenniferVincent Tonia LConaghan Philip GKingsbury Sarah RWatt Fiona E - We performed a secondary analysis of a randomized clinical trial that evaluated stimulation of HIV reservoir through routine vaccines (NCT02707692) to characterize vaccine-induced inflammatory responses and their association with HIV virologic measures following influenza and pneumococcal vaccination in people with HIV (PWH) on suppressive antiretroviral therapy (ART). - Source: PubMed
Publication date: 2026/07/07
Bobadilla RenatoTenenbaum Tara LVanpouille ChristopheWells AlanChaillon AntoineLonergan JosephMuttera LeticiaHarkness LilianaLittle Susan JSmith DaveyGianella Sara - Pancreatic adenocarcinoma (PAAD) has an extremely poor prognosis, and existing prognostic markers fail to fully capture the complex heterogeneity of the tumor microenvironment. This study aimed to integrate ligand-receptor (L-R) interactions, multi-omics data, and deep learning-based pathological images to construct an interpretable multimodal prognostic model and to elucidate the mechanisms underlying the cancer-associated fibroblast (CAF) microenvironment. - Source: PubMed
Publication date: 2026/07/03
Liu KejunTan ZhenyaoTang YezhenLv YongxueBu Yang - Proteins directly impact disease development and act as drug targets. Therefore, we integrated genomic and lung tissue proteomics data to identify lung cancer susceptibility proteins, elucidating genetic mechanisms and candidate drug targets. - Source: PubMed
Publication date: 2026/06/22
Xu ShuaiShi JiajunShu Xiao-OuTao RanDou YongchaoGuo XingyiWen WanqingYang YaohuaZhang BingWu JieDeppen Stephen ALi BingshanZheng WeiLong JirongCai Qiuyin