IL-7, His, Mouse Protein
- Known as:
- Interleukin-7, histidine, Mouse Protein
- Catalog number:
- z03209-50
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- IL-7 His Mouse Protein
Related genes to: IL-7, His, Mouse Protein
- Gene:
- IL7 NIH gene
- Name:
- interleukin 7
- Previous symbol:
- -
- Synonyms:
- IL-7
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-10-12
- Date modifiied:
- 2016-10-11
- Gene:
- IL7R NIH gene
- Name:
- interleukin 7 receptor
- Previous symbol:
- -
- Synonyms:
- CD127, IL7RA
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2019-04-23
Related products to: IL-7, His, Mouse Protein
Related articles to: IL-7, His, Mouse Protein
- The management of treatment strategies in COVID-19 is critical, especially in patients with type 2 diabetes. Non-enzymatic glycation of transmembrane protease serine 2 and angiotensin-converting enzyme 2 during COVID-19 in patients with diabetes may exacerbate immune dysregulation and inflammation. Elevated inflammatory cytokines such as IL-1, IL-2, IL-6, IL-7, and IL-10, tumor necrosis factor-α, interferon-γ, granulocyte-macrophage colony-stimulating factor, and monocyte chemoattractant protein-1 have been observed in COVID-19 patients. This review aims to assess the relationship between inflammatory markers, including C-reactive protein, and micronutrients (vitamins D and C, zinc, and copper) with the severity of COVID-19 infection in patients with type 2 diabetes. A narrative review was conducted through a comprehensive literature search of English-language articles published between 2000 and 2025. The databases searched included PubMed, Scopus, the ISI Web of Science, Cochrane, and Embase. Search terms included COVID-19, infections, type 2 diabetes mellitus, interleukins, and micronutrients. English-language scientific articles, systematic reviews, and meta-analyses were included, while studies lacking sufficient information, letters, comments, and editorials were excluded. Evidence suggests that immune-boosting components such as proteins, vitamins, and minerals can enhance immunity to infections. Vitamins D and C, zinc, and copper play supportive roles in immune function, potentially modulating the inflammatory response in COVID-19 patients with type 2 diabetes. High levels of inflammatory cytokines correlate with increased disease severity in this population. Understanding the interplay between inflammatory markers and micronutrients may guide improved therapeutic strategies for managing COVID-19 in diabetic patients. Further research is warranted to clarify these relationships and optimize clinical outcomes. - Source: PubMed
Publication date: 2026/08/12
Sowti ReyhanehNajafipour FarzadGhaffarzadeh Rad SevilGhorbani HakimehAmirazad Halimeh - Idiopathic multicentric Castleman disease (iMCD) is a heterogeneous cytokine storm disorder involving systemic inflammation, multicentric lymphadenopathy with characteristic histopathology, and life-threatening multiple organ dysfunction. Patients can present with symptoms ranging from thrombocytopenia, anasarca, fever/elevated C-reactive protein (CRP), reticulin myelofibrosis, renal dysfunction, and organomegaly (iMCD-TAFRO) to thrombocytosis, hypergammaglobulinemia, and plasmacytosis (iMCD-IPL), with patients not falling into either group (iMCD-NOS). The molecular mechanisms across the clinical subtypes have not been elucidated and new effective treatments are needed. Here, we performed bulk RNA sequencing and targeted gene expression quantification in lymph node tissue from multiple iMCD clinical subtypes, pathologically related disorders, and controls. We identified 249 upregulated and 42 downregulated genes in iMCD-TAFRO lymph node tissue, which were enriched in the following pathways: angiogenesis, cell proliferation, and various aspects of the humoral and innate immune response. The targeted gene expression analysis revealed shared differentially expressed genes (DEGs) across all three iMCD clinical subtypes, including , , , and . We identified unique DEGs in each iMCD clinical subtype, including (iMCD-TAFRO), (iMCD-IPL), and (iMCD-NOS). Since Clusterin () was significantly upregulated in iMCD but not in related conditions, we performed immunohistochemistry and observed that Clusterin is elevated in the germinal center and mantle zone regions of iMCD patient lymph nodes. A composite model incorporating CLU expression in these lymph node compartments with germinal center features demonstrated strong performance in differentiating iMCD from selected lymphadenopathies. Together, this work identified pathways dysregulated in iMCD lymph nodes and suggests that Clusterin, particularly when integrated with germinal center features, could be a novel biomarker. - Source: PubMed
Publication date: 2026/09/17
Gonzalez Michael VWang KaiwenZinski JosephMumau Melanie DForsyth Katherine SIrvine Abiola HBrandstadter JoshuaGuzman Stacy GZhang LuPierson Sheila KAustin BridgetFajgenbaum David C - T cell exhaustion presents a challenge for antitumor immunotherapy. T memory stem cells (Tscms), whose ability to self-renew can continuously generate effector T cells, offering a way to reverse T cell exhaustion. Here, we propose a Tscm regulation strategy involving the construction of dendritic cell (DC)-targeting CCR7/IL-7 mRNA liposomes to edit CCR7IL-7 DCs in vivo, thus directly promoting Tscm differentiation within tumor-draining lymph nodes (TDLNs). The antigen-presenting CCR7IL-7 DCs migrate to the T-zone within TDLNs via CCR7-mediated signaling and secrete IL-7 to induce naive T cells to differentiate into Tscms. The antigens activate Tscms, promoting continuous Tscm self-renewal and effector T cell generation. The powerful antitumor effects have been observed in B16F10 and 4T1 tumor-bearing mice, and 80% of the mice exhibited suppressed distant tumor formation in the B16F10 prevention model. Overall, this research highlights the importance of Tscm abundance for antitumor immunotherapy and provides high clinical value for developing cancer vaccines. - Source: PubMed
Publication date: 2026/09/30
Fu ShunliMa QingpingGao ShuyingXia ZhenxingMu WeiweiLiang ShuangYuan ShijunLiu JinhuXia YimingLiu XinruiHan LeiqiangLiu YongjunZhang Na - Autologous hematopoietic stem cell transplantation (AHSCT) can induce long-lasting immune tolerance and disease quiescence in patients with severe multiple sclerosis (MS), but the underlying mechanisms are not well understood. We hypothesized that AHSCT would induce persistent decreases in inflammatory cytokines, chemokines, and axoglial damage biomarkers in serum and CSF. - Source: PubMed
Publication date: 2026/09/28
Cooney Laura ALim NohaHarris Kristina MSmilek Dawn EBathala PradeepthiStengelin MartinSigal GeorgeWohlstadter Jacob NCencioni Maria TeresaFernández Velasco José IgnacioMao-Draayer YangFox David AGriffith Linda MNash RichardVillar Luisa MaríaMuraro Paolo A - Individuals with cystic fibrosis (CF) are vulnerable to environmental exposures due to impaired pulmonary defense mechanisms, yet the contribution of the indoor environment to inflammatory signaling in CF remains poorly understood. While prior studies have focused on ambient air pollution and clinical outcomes, less is known about how short-term indoor particulate matter exposure relates to systemic immune biomarkers. In this pilot study, we evaluated associations between household fine particulate matter (PM) concentrations and circulating cytokines in adults with CF. Participants underwent four to eleven days of in-home PM monitoring using real-time air quality sensors. Circulating inflammatory cytokines were measured from blood samples collected using a multiplex immunoassay. PM exposure was characterized using two metrics: mean PM concentration across the monitoring period and the percentage of monitoring time with indoor PM>35 μg/m. Associations between PM exposure and cytokine concentrations were assessed using Spearman rank correlations. While mean PM concentration was not associated with cytokine levels, the percentage of monitoring time with indoor PM>35 μg/m was associated with variation in circulating cytokines. PDGF-AA/BB suggested a moderate, statistically significant positive correlation with the percentage of monitoring time with PM>35 μg/m, while IL-7 and IL-8 showed positive but non-significant trends. TNF-α exhibited a non-significant negative association. These findings suggest that time spent at elevated indoor PM concentrations may be relevant to systemic inflammatory signaling in adults with CF and support further investigation into modifiable indoor environmental exposures. - Source: PubMed
Publication date: 2026/09/26
Zhang MichaelSmolen Kali AChittineni Midhuna SreeHampton Thomas HTaub LilyMellinger DianeAridgides Daniel SAshare AlixPaulin Laura M