IL-11, Human(CHO-expressed) Protein
- Known as:
- Interleukin-11, Human(CHO-expressed) Protein
- Catalog number:
- z03108-25
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- IL-11 Human(CHO-expressed) Protein
Related genes to: IL-11, Human(CHO-expressed) Protein
- Gene:
- IL11 NIH gene
- Name:
- interleukin 11
- Previous symbol:
- -
- Synonyms:
- IL-11, AGIF
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2016-10-11
Related products to: IL-11, Human(CHO-expressed) Protein
Related articles to: IL-11, Human(CHO-expressed) Protein
- Glaesserella parasuis (G. parasuis), the causative agent of Glässer's disease in pigs, relies on adhesion to host epithelial cells and induction of inflammation for pathogenesis. However, the potential role of ST6GALNAC5, a host sialyltransferase involved in glycan modification, in G. parasuis infection remains unclear. Using the porcine kidney epithelial cell line LLC-PK1, we investigated the function of the host sialyltransferase gene ST6GALNAC5 during G. parasuis infection. Infection significantly upregulated ST6GALNAC5 mRNA expression. CRISPR/Cas9-mediated knockout of ST6GALNAC5 reduced bacterial adhesion to and invasion of host cells. Compared to wild-type cells, ST6GALNAC5-KO cells exhibited higher proliferation and survival rates post-infection. Transcriptomic analysis revealed that ST6GALNAC5 knockout alone altered host cell pathways: DNA replication and cell cycle pathways were activated, while antigen processing and presentation and Toll-like receptor signaling pathways were suppressed. Consistently, upon infection, knockout cells showed significantly reduced expression of pro-inflammatory cytokines TNF-α, IL-8, IL-6, and IL-11. These findings demonstrate that ST6GALNAC5 promotes G. parasuis infection by enhancing bacterial adhesion, invasion and potentiating host inflammatory responses. Therefore, ST6GALNAC5 may serve as a potential host-directed target for controlling G. parasuis infection. - Source: PubMed
Publication date: 2026/07/14
Zhou HuanhuanChen XuexueZeng JiayiDuan ShijiaLiu HailongZeng XinqiZhang XiaoyuXu KeXie ShengsongChen Hongbo - GEP-NETs constitute a heterogeneous group of rare cancers arising in biologically diverse microenvironments, while their cytokine profiles remain insufficiently characterized. - Source: PubMed
Publication date: 2026/07/02
Świętek AgataStrzelczyk Joanna KHudy DorotaCzuba Zenon PSnopek-Miśta KarolinaKryj MariuszKuśnierz KatarzynaZeman MarcinOczko-Wojciechowska MalgorzataHandkiewicz-Junak DariaStrzelczyk Janusz - House dust mite (HDM) is a major global inducer of allergic asthma, yet its epigenetic impact on airway tissues remains poorly understood. The aim of this study was to perform an exploratory, hypothesis-generating screening of the DNA methylation changes that occur in lung tissue of mice with robust allergic inflammation compared to saline-exposed controls. - Source: PubMed
Publication date: 2026/07/02
Llinás-Caballero KevinAcevedo NathalieMerid Simon KebedeDonado KarenEspinoza HectorMondol ErnestoReina RandyRegino RonaldBenedetti InésZakzuk JosefinaPuerta LeonardoMelén ErikCaraballo Luis - Cepharanthine is a potential candidate for developing antiviral agents against tick‑borne encephalitis virus (TBEV), which is a major cause of arboviral neuroinvasive diseases in humans. Cepharanthine is the only bisbenzylisoquinoline alkaloid for treating human diseases due to its unique pharmacological properties. Management of endoplasmic reticulum stress and inflammation response is implicated in therapeutic strategies for TBEV infection. The present study aimed to explore the antiviral efficacy and underlying mechanisms of cepharanthine against TBEV in human lung adenocarcinoma A549 cells and neuroblastoma SH‑SY5Y cells. In co‑treatment and pre‑treatment schemes, cepharanthine exhibited a potent inhibitory effect on TBEV propagation. The antiviral effect of cepharanthine was evidenced by a reduction in TBEV RNA replication, viral protein expression and infectious virus release. The levels of inflammatory cytokines, including tumor necrosis factor‑α, interleukin (IL‑) 1β and IL‑11, induced by TBEV infection were markedly decreased in A549 cells treated with cepharanthine. The induction of IL‑11 was impaired in infected SH‑SY5Y cells treated with cepharanthine. TBEV infection upregulated the expression of C/EBP homologous protein, which was downregulated by cepharanthine treatment. Phosphorylation of eukaryotic initiation factor 2α was enhanced upon cepharanthine treatment during TBEV infection. These results demonstrated that cepharanthine possesses anti‑TBEV efficacy and that modulation of the stress and inflammation response by cepharanthine may be involved in antiviral mechanisms. The results of the present study support further investigation of cepharanthine as an antiviral agent against TBEV. - Source: PubMed
Publication date: 2026/07/17
Tang Wan-DaZhao Lan-Juan - Several radiation medical countermeasures (MCMs) are currently approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiation syndrome (H-ARS). Continued development of additional candidates remains a priority to enhance force protection capabilities, combat readiness, and operational preparedness in nuclear/radiological threat environments. One such candidate under development is BBT-059, a long-acting PEGylated interleukin-11 (IL-11) analog with known hematopoietic-promoting and anti-apoptotic properties. BBT-059 is under advanced development as a potential radiation MCM for H-ARS and has been shown to improve survival in lethally irradiated murine models; however, its proteomic responses after irradiation have not been fully characterized in nonhuman primates (NHPs). In this study, NHPs exposed to 4 Gy total-body gamma radiation were subsequently treated with a single subcutaneous dose of either 37.5 or 75 µg/kg of BBT-059 at 24 h postirradiation, and longitudinal serum proteomic profiling was performed using a mass spectrometry (MS)-based approach. Proteomic changes were compared to baseline levels to comprehensively identify time-dependent changes induced by irradiation and BBT-059 administration. These analyses revealed changes in proteins related to inflammation, innate immune activation, and hematological and platelet functions, which peaked at days 2 and 4 and gradually decreased to near baseline levels by the end of the study. Pathway enrichment analysis identified consistent activation of neutrophil degranulation, platelet degranulation, insulin-like growth factor transport, and calcium signaling pathways. - Source: PubMed
Publication date: 2026/07/17
Carpenter Alana DBrink Matthew WLi YaoxiangKandhavelu JeyalakshmiPetrus Sarah AWise Stephen YFatanmi Oluseyi OFam Christine MCarlson Sharon JCox George NCheema Amrita KSingh Vijay K